E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [HMG1]
Description | HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]; transcript_id=YML075C_mRNA |
Organism | YEAST - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
Locus | [ Chromosome XIII ]: 115734 ... 118898 |
Number of exons | 1 |
Exons | complement(115734..118898) |