Gene YEAST04594 (HMDH1_YEAST)

E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [HMG1]

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General Information

DescriptionHMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]; transcript_id=YML075C_mRNA
Organism YEAST - Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Locus[ Chromosome XIII ]: 115734 ... 118898
Number of exons1
Exonscomplement(115734..118898)

IDs and Cross-references

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