Gene YEAST00467 (DER1_YEAST)

E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Degradation in the endoplasmic reticulum protein 1 [DER1]

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General Information

DescriptionER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1 [Source:SGD;Acc:S000000405]; transcript_id=YBR201W_mRNA
Organism YEAST - Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Locus[ Chromosome II ]: 623576 ... 624211
Number of exons1
Exons623576..624211

IDs and Cross-references