OMA Group 763670 ?

prolyl endopeptidase


This group has 405 members: E240 A3 B162

Fingerprint: ACMTQRP

H
U
M
A
N
G
O
R
G
O
P
A
N
P
A
P
A
N
T
R
P
O
N
A
B
N
O
M
L
E
C
H
L
S
B
M
A
C
M
U
P
A
P
A
N
C
A
L
J
A
T
A
R
S
Y
M
I
C
M
U
O
T
O
G
A
R
A
B
I
T
O
C
H
P
R
D
I
P
O
R
F
U
K
D
A
C
A
V
P
O
C
H
I
L
A
O
C
T
D
E
J
A
C
J
A
M
O
U
S
E
R
A
T
N
O
N
A
N
G
A
I
C
T
T
R
T
U
P
B
E
C
A
N
L
F
M
U
S
P
F
A
I
L
M
E
F
E
L
C
A
T
U
R
T
R
B
O
V
I
N
S
H
E
E
P
P
I
G
X
X
V
I
C
P
A
P
T
E
V
A
M
Y
O
L
U
E
R
I
E
U
S
O
R
A
R
H
O
R
S
E
P
R
O
C
A
L
O
X
A
F
E
C
H
T
E
D
A
S
N
O
C
H
O
H
O
S
A
R
H
A
M
O
N
D
O
M
A
C
E
U
O
R
N
A
N
A
N
A
P
L
M
E
L
G
A
C
H
I
C
K
F
I
C
A
L
T
A
E
G
U
P
E
L
S
I
A
N
O
C
A
X
E
N
T
R
L
A
T
C
H
L
E
P
O
C
G
A
S
A
C
T
A
K
R
U
T
E
T
N
G
O
R
Y
L
A
N
O
T
F
U
P
O
E
F
O
X
I
P
M
A
O
R
E
N
I
H
I
P
C
M
G
A
D
M
O
A
S
T
M
X
D
A
N
R
E
B
R
A
F
L
C
I
O
I
N
C
I
O
S
A
S
T
R
P
U
S
C
H
M
D
S
C
H
M
A
P
R
I
P
A
C
A
E
B
E
C
A
E
B
R
C
A
E
E
L
C
A
E
J
A
C
A
E
R
E
B
R
U
M
A
L
O
A
L
O
O
N
C
V
O
T
H
E
C
L
S
T
R
R
B
M
E
L
H
A
T
R
I
S
P
S
A
R
S
C
T
E
T
U
R
I
X
O
S
C
S
T
R
M
M
D
A
P
P
U
B
O
M
M
O
D
A
N
P
L
H
E
L
M
E
D
E
N
P
D
T
R
I
C
A
D
R
O
G
R
D
R
O
A
N
D
R
O
B
P
D
R
O
E
L
D
R
O
E
U
D
R
O
F
C
D
R
O
E
R
D
R
O
M
E
D
R
O
S
E
D
R
O
S
I
D
R
O
Y
A
D
R
O
K
I
D
R
O
R
H
D
R
O
B
M
D
R
O
T
K
D
R
O
P
E
D
R
O
P
S
D
R
O
W
I
D
R
O
M
O
D
R
O
V
I
L
U
C
C
U
A
N
O
G
A
A
N
O
D
A
A
E
D
A
E
C
U
L
Q
U
A
P
I
M
E
B
O
M
I
M
L
I
N
H
U
O
O
C
B
I
C
A
M
F
O
A
T
T
C
E
H
A
R
S
A
N
A
S
V
I
R
H
O
P
R
D
I
A
C
I
P
E
D
H
C
Z
O
O
N
E
H
Y
P
D
U
H
E
L
R
O
C
A
P
I
1
C
A
P
T
E
L
I
N
U
N
C
R
A
G
I
O
C
T
B
M
L
O
T
G
I
N
E
M
V
E
H
Y
D
V
U
M
N
E
L
E
T
R
I
A
D
A
M
P
Q
E
M
O
N
B
E
S
A
L
R
5
S
C
H
C
R
S
C
H
J
Y
S
C
H
O
Y
S
C
H
P
O
T
U
B
M
M
A
S
P
A
C
A
S
P
C
L
N
E
O
F
I
A
S
P
F
N
A
S
P
G
L
A
S
P
O
R
A
S
P
T
N
E
M
E
N
D
E
M
E
N
I
A
S
P
F
U
P
E
N
C
H
P
E
N
R
W
T
A
L
S
N
C
O
C
I
M
P
A
R
B
A
C
O
N
A
1
D
O
T
S
N
P
A
S
F
U
Z
Y
M
T
R
A
U
R
P
U
L
E
P
M
J
P
H
A
N
D
P
H
A
N
O
C
O
C
S
N
C
O
C
L
U
P
Y
R
T
R
B
L
U
G
R
B
O
T
F
B
S
C
L
S
1
C
O
L
G
R
C
O
L
S
U
V
E
R
D
A
V
E
R
D
V
C
O
R
M
M
H
Y
P
A
I
H
Y
P
J
E
H
Y
P
V
G
G
I
B
M
7
F
U
S
C
1
F
U
S
O
4
G
I
B
Z
A
N
E
C
H
A
C
R
Y
P
A
M
A
G
G
R
M
A
G
O
7
M
A
G
P
6
T
H
I
H
E
N
E
U
C
R
N
E
U
T
9
P
E
S
F
W
C
A
N
A
L
C
A
N
A
W
L
O
D
E
L
D
E
B
H
A
P
I
C
G
U
P
I
C
S
T
S
P
A
P
N
C
A
N
T
E
Y
A
R
L
I
K
O
M
P
G
D
E
K
B
R
A
S
H
G
O
K
A
Z
N
A
K
L
U
L
A
L
A
C
T
C
C
A
N
G
A
Y
E
A
S
T
V
A
N
P
O
Z
Y
G
R
O
A
U
R
S
T
P
U
N
S
T
G
L
O
T
R
F
O
M
M
E
P
O
S
P
M
F
O
M
P
I
G
R
I
F
R
W
O
L
C
O
P
H
A
C
H
P
H
L
G
I
D
I
C
S
Q
T
R
A
V
S
H
E
T
A
N
S
T
E
H
R
S
E
R
I
D
A
G
A
B
I
C
O
P
C
I
S
C
H
C
O
L
A
C
B
I
C
O
N
P
W
C
R
Y
G
A
C
R
Y
G
R
C
R
Y
N
J
T
R
E
M
E
M
I
X
O
S
P
U
C
G
R
P
U
C
G
T
U
S
T
H
O
U
S
T
M
A
W
A
L
S
E
B
A
T
D
E
B
A
T
D
J
S
P
I
P
N
M
U
C
C
I
R
H
I
O
R
P
H
Y
B
L
C
A
P
O
3
C
R
E
F
R
B
A
B
B
I
T
H
E
A
N
T
H
E
P
A
E
I
M
A
C
E
I
M
M
A
H
A
M
H
A
T
O
X
G
O
T
O
X
G
V
V
I
T
B
C
I
C
H
M
U
P
A
R
T
E
P
S
E
P
J
S
T
Y
L
E
E
N
T
D
S
E
N
T
H
I
E
N
T
N
P
P
O
L
P
P
D
I
C
D
I
D
I
C
P
U
G
U
I
T
H
B
O
D
S
A
L
E
I
D
B
L
E
I
I
N
L
E
I
M
A
L
E
I
M
U
L
E
I
B
R
L
E
P
S
E
T
R
Y
B
2
G
I
A
I
B
G
I
A
I
C
G
I
A
I
A
E
M
I
H
U
N
A
E
G
R
B
I
G
N
C
P
L
A
B
S
G
A
L
S
U
C
H
O
C
R
P
H
A
T
C
T
H
A
O
C
T
H
A
P
S
N
A
N
G
C
H
Y
A
A
E
P
H
Y
I
T
P
H
Y
N
I
P
H
Y
P
R
P
H
Y
P
N
P
H
Y
R
M
S
A
P
P
C
E
C
T
S
I
A
U
R
A
N
C
H
L
R
E
V
O
L
C
A
C
H
L
V
A
O
S
T
L
U
M
I
C
C
C
M
I
C
P
C
K
L
E
F
L
P
H
Y
P
A
M
A
R
P
O
O
R
Y
B
R
O
R
Y
G
L
O
R
Y
L
O
O
R
Y
P
U
O
R
Y
R
U
O
R
Y
N
I
O
R
Y
S
I
O
R
Y
S
J
B
R
A
D
I
H
O
R
V
V
A
E
G
T
A
W
H
E
A
T
T
R
I
U
A
E
R
A
T
E
S
O
R
B
I
M
A
I
Z
E
S
E
T
I
T
M
U
S
A
M
C
H
E
Q
I
H
E
L
A
N
N
I
C
A
T
S
O
L
L
C
S
O
L
T
U
C
U
C
S
A
M
E
D
T
R
L
O
T
J
A
S
O
Y
B
N
P
H
A
V
U
L
U
P
A
N
M
A
N
E
S
P
O
P
T
R
P
R
U
P
E
A
R
A
A
L
B
R
A
R
P
B
R
A
N
A
B
R
A
O
L
A
R
A
L
Y
A
R
A
T
H
T
H
E
C
C
C
O
C
A
P
G
O
S
A
R
G
O
S
H
I
G
O
S
R
A
V
I
T
V
I
A
M
B
T
C
S
E
L
M
L
H
E
I
A
B
K
O
R
C
O
A
C
I
S
3
C
A
L
L
D
A
E
R
P
E
S
T
A
H
D
S
T
A
M
F
H
Y
P
B
U
P
Y
R
O
C
F
E
R
F
K
A
C
I
H
W
M
E
T
C
R
M
E
T
S
5
S
U
L
I
H
S
U
L
I
D
S
U
L
I
L
S
U
L
I
M
S
U
L
I
A
S
U
L
I
K
S
U
L
I
R
S
U
L
I
Y
S
U
L
I
N
S
U
L
S
9
S
U
L
S
O
S
U
L
T
O
P
Y
R
A
E
P
Y
R
A
R
P
Y
R
C
J
P
Y
R
I
L
P
Y
R
N
V
P
Y
R
O
T
T
H
E
T
K
T
H
E
U
7
V
U
L
D
I
V
U
L
M
7
A
C
I
B
4
A
C
I
S
0
H
A
L
H
T
H
A
L
M
A
H
A
L
M
D
H
A
L
J
B
H
A
L
S
3
H
A
L
S
A
H
A
L
M
T
H
A
L
V
D
H
A
L
B
P
H
A
L
W
D
H
A
L
W
C
H
A
L
L
T
H
A
L
X
S
H
A
L
T
V
H
A
L
R
X
N
A
T
A
1
N
A
T
M
M
N
A
T
P
1
N
A
T
S
J
N
A
T
G
S
M
E
T
P
E
M
E
T
H
6
M
E
T
S
G
P
Y
R
A
B
P
Y
R
F
U
P
Y
R
H
O
P
Y
R
S
N
P
Y
R
Y
C
T
H
E
B
M
T
H
E
G
J
T
H
E
K
O
T
H
E
L
N
T
H
E
O
N
T
H
E
S
M
T
H
E
S
4
P
I
C
T
O
T
H
E
A
C
T
H
E
V
O
A
C
I
C
5
K
O
R
V
E
G
R
A
M
M
G
R
A
T
M
T
E
R
R
K
T
E
R
S
S
C
H
L
T
F
S
O
L
U
E
A
C
I
F
D
A
C
I
C
1
T
H
E
B
D
A
R
C
H
D
B
I
F
A
A
B
I
F
A
R
B
I
F
A
0
B
I
F
A
B
B
I
F
L
B
B
I
F
A
S
B
I
F
A
V
B
I
F
A
P
B
I
F
B
P
B
I
F
B
S
B
I
F
B
A
B
I
F
D
B
B
I
F
L
D
B
I
F
L
O
B
I
F
L
1
B
I
F
L
S
B
I
F
L
2
B
I
F
L
M
B
I
F
L
J
G
A
R
V
4
G
A
R
V
3
G
A
R
V
H
C
A
T
A
D
C
O
R
A
7
C
O
R
D
2
C
O
R
D
3
C
O
R
D
7
C
O
R
D
I
C
O
R
D
D
C
O
R
D
H
C
O
R
D
J
C
O
R
D
K
C
O
R
D
L
C
O
R
D
W
C
O
R
D
V
C
O
R
E
F
C
O
R
G
L
C
O
R
G
K
C
O
R
G
B
C
O
R
J
K
C
O
R
K
4
C
O
R
P
1
C
O
R
P
2
C
O
R
P
F
C
O
R
P
9
C
O
R
R
G
C
O
R
U
B
C
O
R
U
7
C
O
R
V
D
G
O
R
B
4
G
O
R
P
V
H
O
Y
S
D
M
Y
C
A
S
M
Y
C
A
1
M
Y
C
P
A
M
Y
C
I
A
M
Y
C
L
B
M
Y
C
L
E
M
Y
C
M
M
M
Y
C
S
J
M
Y
C
S
K
M
Y
C
S
S
M
Y
C
A
0
M
Y
C
B
O
M
Y
C
B
P
M
Y
C
B
T
M
Y
C
C
P
M
Y
C
T
A
M
Y
C
T
U
M
Y
C
T
C
M
Y
C
T
D
M
Y
C
T
F
M
Y
C
T
K
M
Y
C
U
A
M
Y
C
A
9
M
Y
C
S
D
M
Y
C
R
N
M
Y
C
S
2
M
Y
C
V
P
M
Y
C
C
N
M
Y
C
S
R
M
Y
C
G
I
N
O
C
C
G
N
O
C
F
A
R
H
O
E
4
R
H
O
H
1
R
H
O
J
R
R
H
O
O
B
S
E
G
R
D
T
S
U
P
D
F
R
A
A
A
F
R
A
C
C
F
R
A
I
E
F
R
A
S
N
B
L
A
S
D
G
E
O
O
G
M
O
D
M
B
S
T
A
N
L
K
I
N
R
D
B
E
U
C
1
B
R
E
L
N
C
E
L
F
A
C
E
L
F
N
C
E
L
G
A
B
R
A
F
D
K
Y
T
S
D
J
O
N
D
D
C
L
A
M
3
C
L
A
M
S
L
E
I
X
X
M
I
C
T
S
A
R
T
S
2
G
L
U
A
R
K
O
C
R
D
M
I
C
L
C
P
A
E
A
T
P
S
E
C
P
P
S
E
P
M
R
E
N
S
M
R
O
T
D
C
R
O
T
M
D
I
S
O
V
2
X
Y
L
C
X
S
A
N
K
S
T
R
O
W
8
T
R
O
W
T
A
C
T
M
4
A
C
T
S
5
M
I
C
A
I
M
I
C
S
L
S
A
L
A
I
S
A
L
T
O
V
E
R
M
A
N
A
K
M
Y
K
R
I
F
D
N
O
C
S
J
A
C
I
A
4
M
I
C
P
N
P
R
O
F
C
P
S
E
P
Q
A
C
T
M
D
A
M
Y
M
S
A
M
Y
M
U
P
S
E
U
X
S
A
C
V
D
S
A
C
E
N
S
A
C
E
S
R
U
B
X
D
K
I
T
S
K
S
T
R
A
W
S
T
R
B
B
S
T
R
E
N
S
T
R
C
O
S
T
R
G
G
S
T
R
H
J
S
T
R
F
A
S
T
R
S
W
S
T
R
V
P
N
O
C
A
A
N
O
C
D
D
T
H
E
F
Y
S
T
R
R
D
T
H
E
C
D
C
O
N
W
I
R
H
O
M
4
S
A
L
R
D
S
A
L
R
M
B
A
C
F
6
B
A
C
F
N
B
A
C
F
R
B
A
C
T
6
B
A
C
S
H
B
A
C
T
N
B
A
C
V
8
O
D
O
S
D
P
A
L
P
W
P
O
R
A
D
P
O
R
E
A
P
O
R
G
3
P
O
R
G
I
P
R
E
D
F
P
R
E
I
7
P
R
E
M
B
P
R
E
R
2
A
L
I
F
I
P
A
R
D
8
T
A
N
F
A
C
H
I
P
D
N
I
A
K
G
B
E
R
L
S
B
E
L
B
D
C
Y
C
M
S
E
C
H
V
K
D
Y
A
F
D
E
M
T
O
G
L
E
A
B
4
R
U
N
S
L
S
P
I
L
D
M
A
R
T
H
F
L
U
T
R
O
W
E
H
D
A
E
Q
S
U
C
A
P
C
C
C
A
P
O
D
C
E
L
A
D
C
E
L
L
C
C
R
O
A
H
D
O
K
S
4
F
L
A
B
F
F
L
A
C
A
F
L
A
I
G
F
L
A
J
1
F
L
A
P
J
G
R
A
F
K
L
A
C
S
5
L
E
E
B
M
M
A
R
S
H
M
U
R
R
D
N
O
N
D
D
O
R
N
R
L
P
S
Y
T
T
R
I
E
A
R
R
O
B
B
H
W
E
E
V
C
Z
O
B
G
A
Z
U
N
P
S
F
L
A
B
3
H
A
L
H
1
S
A
P
G
L
P
E
D
H
D
P
S
E
S
L
S
O
L
C
M
S
P
H
S
2
P
A
R
U
W
P
A
R
A
V
S
I
M
N
Z
C
H
L
P
8
C
H
L
T
E
C
H
L
L
2
C
H
L
P
B
C
H
L
P
D
C
H
L
P
M
C
H
L
T
3
C
H
L
L
7
P
R
O
A
2
A
N
A
T
U
C
A
L
A
S
C
H
L
A
D
C
H
L
S
Y
C
H
L
A
A
R
O
S
C
S
R
O
S
S
1
H
E
R
A
2
S
P
H
T
D
T
H
E
R
P
G
L
O
V
I
A
N
A
C
C
N
O
S
P
7
N
O
S
S
7
N
O
S
S
1
A
N
A
V
T
N
O
S
A
0
H
A
L
P
7
C
Y
A
A
P
C
Y
A
S
C
M
I
C
A
N
C
Y
A
A
5
C
Y
A
P
7
C
Y
A
P
4
C
Y
A
P
2
C
Y
A
P
8
C
Y
A
P
0
A
R
T
P
N
T
R
I
E
I
L
Y
N
S
P
S
T
A
C
7
A
C
A
M
1
C
H
A
P
6
S
Y
N
Y
3
P
R
O
M
S
P
R
O
M
4
P
R
O
M
2
P
R
O
M
0
P
R
O
M
3
P
R
O
M
9
P
R
O
M
M
P
R
O
M
5
P
R
O
M
1
P
R
O
M
T
P
R
O
M
A
P
R
O
M
P
C
Y
A
G
P
S
Y
N
P
6
S
Y
N
P
2
S
Y
N
S
7
S
Y
N
S
3
S
Y
N
S
C
S
Y
N
S
9
S
Y
N
J
B
S
Y
N
J
A
S
Y
N
R
3
S
Y
N
P
W
S
Y
N
P
X
T
H
E
E
B
D
E
I
D
V
D
E
I
G
D
D
E
I
G
I
D
E
I
M
L
D
E
I
P
D
D
E
I
R
A
T
R
U
R
R
M
A
R
H
T
M
E
I
R
D
M
E
I
S
D
O
C
E
P
5
T
H
E
T
2
T
H
E
T
8
T
H
E
T
G
A
L
I
A
T
A
L
I
A
D
B
A
C
A
3
B
A
C
A
S
B
A
C
A
N
B
A
C
A
A
B
A
C
A
C
B
A
C
A
1
B
A
C
C
J
B
A
C
C
3
B
A
C
C
7
B
A
C
C
0
B
A
C
C
1
B
A
C
C
R
B
A
C
C
4
B
A
C
C
2
B
A
C
C
Q
B
A
C
C
Z
B
A
C
A
I
B
A
C
S
K
B
A
C
L
D
B
A
C
M
Q
B
A
C
M
D
B
A
C
W
K
B
A
C
P
E
B
A
C
P
2
B
A
C
S
T
B
A
C
P
Z
B
A
C
P
T
B
A
C
S
U
B
A
C
A
H
B
A
C
T
0
B
A
C
H
K
B
A
C
T
1
B
A
C
V
Z
G
E
O
K
A
G
E
O
S
W
G
E
O
S
0
G
E
O
S
Y
G
E
O
T
N
L
Y
S
S
C
O
C
E
I
H
G
E
O
T
C
B
R
E
B
N
G
E
O
S
4
P
A
E
P
6
P
A
E
P
S
P
A
E
T
H
S
O
L
S
S
B
A
C
I
E
L
A
C
B
A
L
A
C
C
D
L
A
C
C
B
L
A
C
C
C
L
A
C
C
Z
L
A
C
D
2
L
A
C
D
A
L
A
C
D
B
L
A
C
P
3
L
A
C
R
G
L
A
C
R
L
O
E
N
O
B
S
T
R
S
7
S
T
R
P
7
S
T
R
P
J
S
T
R
R
6
S
T
R
Z
I
S
T
R
P
2
S
T
R
P
N
A
L
K
O
O
S
U
L
A
D
S
U
L
A
T
A
C
E
S
D
P
E
P
D
6
P
E
P
D
R
S
Y
M
T
H
N
A
T
T
J
C
A
L
S
4
T
H
E
I
A
T
H
E
M
3
T
H
E
P
3
T
H
E
S
X
T
H
E
P
X
E
R
Y
R
F
A
N
A
P
D
F
I
N
M
2
F
U
S
N
N
S
T
R
M
9
G
E
M
A
T
I
G
N
A
J
M
E
L
R
P
I
S
O
P
I
S
I
N
A
D
P
I
R
S
D
R
H
O
B
A
R
U
B
B
R
A
S
T
E
C
B
R
E
S
C
C
A
U
S
T
C
A
U
S
K
C
A
U
V
C
C
A
U
V
N
P
H
E
Z
H
P
A
R
B
H
P
E
L
S
M
P
E
L
U
B
B
A
R
B
K
B
A
R
C
7
B
A
R
G
A
B
A
R
H
E
B
A
R
Q
U
B
A
R
T
1
B
A
R
V
W
B
E
I
I
9
M
E
T
S
B
B
R
A
D
U
B
R
A
S
B
B
R
A
S
O
N
I
T
H
X
N
I
T
W
N
R
H
O
P
A
R
H
O
P
5
R
H
O
P
B
R
H
O
P
S
R
H
O
P
X
R
H
O
P
2
R
H
O
P
T
B
R
U
A
2
B
R
U
A
1
B
R
U
A
B
B
R
U
C
2
B
R
U
M
5
B
R
U
M
E
B
R
U
M
B
B
R
U
M
C
B
R
U
O
2
B
R
U
S
U
B
R
U
S
I
O
C
H
A
4
B
L
A
V
I
H
Y
P
D
A
H
Y
P
S
M
P
E
L
H
B
R
H
O
V
T
M
E
T
N
O
M
E
T
R
J
M
E
T
S
4
M
E
T
E
A
M
E
T
C
4
M
E
T
E
D
M
E
T
E
P
M
E
T
P
B
M
E
T
S
Z
C
H
E
S
B
M
E
S
A
W
M
E
S
C
W
R
H
I
L
O
A
G
R
S
H
A
G
R
F
C
A
G
R
R
K
A
G
R
V
S
R
H
I
E
C
R
H
I
E
6
R
H
I
L
S
R
H
I
L
W
R
H
I
L
3
R
H
I
F
H
S
I
N
F
N
R
H
I
M
E
S
I
N
M
K
S
I
N
M
B
S
I
N
M
M
S
I
N
M
W
P
A
R
L
1
A
Z
O
C
5
S
T
A
N
D
X
A
N
P
2
H
I
R
B
I
H
Y
P
N
A
M
A
R
M
M
K
E
T
V
W
P
S
E
U
V
R
H
O
S
1
A
C
E
P
3
A
C
I
C
J
A
C
I
M
A
G
L
U
D
A
G
L
U
O
X
K
O
M
M
N
R
H
O
C
S
M
I
D
M
I
O
R
I
T
B
O
R
I
T
I
R
I
C
A
E
R
I
C
A
H
R
I
C
A
G
R
I
C
A
C
R
I
C
B
8
R
I
C
B
R
R
I
C
C
K
R
I
C
C
N
R
I
C
F
E
R
I
C
J
Y
R
I
C
M
5
R
I
C
M
S
R
I
C
P
T
R
I
C
P
U
R
I
C
P
3
R
I
C
P
R
R
I
C
P
P
R
I
C
R
3
R
I
C
R
O
R
I
C
R
S
R
I
C
S
1
R
I
C
T
Y
E
R
Y
L
H
N
O
V
A
D
S
P
H
J
U
S
P
H
W
W
S
P
H
A
L
Z
Y
M
M
A
Z
Y
M
M
O
Z
Y
M
M
N
Z
Y
M
M
T
P
O
L
G
S
A
C
H
X
A
B
O
R
A
1
B
O
R
B
R
B
O
R
B
M
B
O
R
P
A
B
O
R
P
1
B
O
R
P
C
B
O
R
P
E
B
O
R
P
D
P
U
S
S
T
B
U
R
C
M
B
U
R
A
4
B
U
R
C
J
B
U
R
C
A
B
U
R
C
H
B
U
R
C
C
B
U
R
L
3
B
U
R
M
1
B
U
R
V
G
B
U
R
G
S
B
U
R
G
B
B
U
R
M
A
B
U
R
M
9
B
U
R
M
7
B
U
R
M
S
B
U
R
P
0
B
U
R
P
1
B
U
R
P
6
B
U
R
P
S
B
U
R
S
C
B
U
R
S
G
B
U
R
T
A
C
U
P
T
R
P
A
R
P
J
P
A
R
X
L
A
C
I
A
P
A
C
I
A
C
D
E
L
A
S
D
E
L
S
C
V
A
R
P
E
V
A
R
P
S
C
O
L
F
T
L
E
P
C
P
M
E
T
P
P
R
U
B
G
I
C
H
R
V
O
P
S
E
U
L
N
E
I
G
1
N
E
I
G
2
N
E
I
M
L
N
E
I
M
A
N
E
I
M
W
N
E
I
M
B
N
E
I
M
7
N
E
I
M
H
N
E
I
M
G
N
E
I
M
M
N
E
I
M
P
N
E
I
M
O
N
E
I
M
N
N
E
I
M
0
N
E
I
M
8
N
E
I
M
F
N
I
T
M
U
A
E
R
H
H
A
E
R
S
4
A
E
R
V
B
O
C
E
S
G
T
O
L
A
T
A
L
T
M
B
A
L
T
M
S
A
L
T
M
E
A
L
T
M
D
A
L
T
N
A
M
A
R
A
H
C
O
L
P
3
F
E
R
B
D
I
D
I
L
O
P
S
E
A
6
P
S
E
H
T
P
S
E
U
9
P
S
Y
I
N
S
H
E
A
M
S
H
E
B
5
S
H
E
B
8
S
H
E
B
9
S
H
E
B
2
S
H
E
B
6
S
H
E
D
O
S
H
E
F
N
S
H
E
H
H
S
H
E
L
P
S
H
E
O
N
S
H
E
P
A
S
H
E
P
W
S
H
E
P
2
S
H
E
P
C
S
H
E
S
H
S
H
E
S
A
S
H
E
S
M
S
H
E
S
R
S
H
E
S
W
S
H
E
V
D
S
H
E
W
M
C
A
R
H
6
D
I
C
N
V
C
E
L
J
U
S
A
C
D
2
S
I
M
A
S
T
E
R
T
T
N
I
T
H
N
N
I
T
O
C
N
I
T
W
C
A
L
K
E
H
H
A
L
H
L
T
H
I
S
K
C
I
T
K
8
C
I
T
R
I
C
R
O
S
8
C
R
O
T
Z
E
N
T
A
L
E
N
T
C
C
E
N
T
3
8
E
C
O
L
X
E
C
O
5
5
E
C
O
D
1
E
C
O
K
O
E
C
O
L
W
E
C
O
B
B
E
C
O
B
D
E
C
O
L
I
E
C
O
D
H
E
C
O
B
W
E
C
O
S
E
E
C
O
S
M
E
C
O
U
M
E
C
O
U
T
E
C
O
B
R
E
C
O
L
C
E
C
O
1
0
E
C
O
1
E
E
C
O
1
A
E
C
O
2
7
E
C
O
2
4
E
C
O
S
5
E
C
O
5
7
E
C
O
5
E
E
C
O
5
T
E
C
O
L
U
E
C
O
K
I
E
C
O
K
1
E
C
O
2
6
E
C
O
4
4
E
C
O
4
5
E
C
O
C
B
E
C
O
L
6
E
C
O
L
5
E
C
O
H
1
E
C
O
7
I
E
C
O
8
A
E
C
O
8
1
E
C
O
8
N
E
C
O
H
S
E
C
O
A
B
E
S
C
F
3
K
L
E
A
K
K
L
E
O
K
K
L
E
P
3
K
L
E
P
7
K
L
E
P
H
K
L
E
V
T
E
N
T
L
S
S
A
L
B
C
S
A
L
D
C
S
A
L
A
4
S
A
L
C
H
S
A
L
P
S
S
A
L
H
S
S
A
L
P
B
S
A
L
P
C
S
A
L
S
V
S
A
L
E
P
S
A
L
G
2
S
A
L
N
S
S
A
L
P
K
S
A
L
P
A
S
A
L
T
I
S
A
L
T
4
S
A
L
T
D
S
A
L
T
Y
S
A
L
T
1
S
A
L
T
S
S
A
L
A
R
S
H
I
D
S
S
H
I
F
L
S
H
I
F
8
S
H
I
F
2
S
H
I
S
S
S
H
I
B
C
E
N
T
B
F
E
R
W
A
E
E
R
W
A
C
E
R
W
B
E
E
R
W
P
6
E
R
W
P
E
E
R
W
S
E
E
R
W
T
9
P
A
N
A
A
P
A
N
A
M
P
A
N
S
A
P
A
N
V
C
E
D
W
I
9
E
D
W
T
E
E
D
W
T
F
P
H
O
A
A
P
H
O
L
L
P
R
O
M
H
P
R
O
R
D
P
R
O
S
M
X
E
N
B
S
D
I
C
C
1
D
I
C
D
3
D
I
C
P
7
D
I
C
Z
5
P
E
C
A
S
P
E
C
C
P
P
E
C
P
W
S
O
D
G
M
R
A
H
A
C
R
A
H
S
Y
S
E
R
F
O
S
E
R
S
A
S
E
R
P
5
Y
E
R
E
8
Y
E
R
E
1
Y
E
R
E
3
Y
E
R
P
E
Y
E
R
P
D
Y
E
R
P
1
Y
E
R
P
P
Y
E
R
P
Z
Y
E
R
P
G
Y
E
R
P
A
Y
E
R
P
N
Y
E
R
P
H
Y
E
R
P
S
Y
E
R
P
B
Y
E
R
P
3
Y
E
R
P
Y
Y
E
R
R
U
C
O
X
B
2
C
O
X
B
1
C
O
X
B
N
C
O
X
B
R
C
O
X
B
U
L
E
G
L
N
L
E
G
P
C
L
E
G
P
L
L
E
G
P
A
L
E
G
P
2
L
E
G
P
H
A
L
C
D
B
C
H
R
S
D
H
A
L
E
D
K
A
N
K
D
N
E
P
C
E
M
O
R
C
R
A
Z
O
V
D
P
S
E
A
E
P
S
E
A
8
P
S
E
A
7
P
S
E
A
B
P
S
E
A
A
P
S
E
B
N
P
S
E
E
4
P
S
E
P
F
P
S
E
F
S
P
S
E
F
1
P
S
E
K
B
P
S
E
M
N
P
S
E
M
Y
P
S
E
F
5
P
S
E
P
K
P
S
E
P
1
P
S
E
P
B
P
S
E
P
G
P
S
E
P
W
P
S
E
1
4
P
S
E
U
5
P
S
E
U
T
P
S
E
U
2
P
S
E
S
M
A
L
I
F
1
A
L
I
F
M
P
H
O
P
R
V
I
B
A
E
V
I
B
C
B
V
I
B
C
H
V
I
B
C
J
V
I
B
C
3
V
I
B
C
M
V
I
B
P
A
V
I
B
T
L
V
I
B
V
U
V
I
B
V
M
V
I
B
V
Y
F
R
A
A
D
L
Y
S
E
N
P
S
E
U
P
P
S
E
U
U
S
T
R
M
K
S
T
R
M
5
X
A
N
A
P
X
A
N
C
8
X
A
N
C
P
X
A
N
C
B
X
A
N
A
C
X
A
N
C
5
X
A
N
O
R
X
A
N
O
M
X
A
N
O
P
X
Y
L
F
A
X
Y
L
F
M
X
Y
L
F
2
X
Y
L
F
T
X
Y
L
F
G
H
A
L
M
S
B
D
E
B
A
D
E
S
A
H
D
E
S
M
R
D
E
S
A
D
G
E
O
L
S
A
N
A
D
2
A
N
A
D
E
A
N
A
D
F
A
N
A
S
K
S
T
I
A
D
C
O
R
C
M
M
Y
X
F
H
M
Y
X
S
D
M
Y
X
X
D
H
A
L
O
1
S
O
R
C
5
B
R
A
H
W
B
R
A
I
P
B
R
A
P
9
S
P
I
A
Z
T
R
E
D
E
A
M
I
C
L
T
H
E
T
1
K
O
S
O
T
P
E
T
M
O
F
E
R
N
B
F
E
R
P
D
T
H
E
A
B
T
H
E
M
4
P
S
E
L
T
O
P
I
T
P
Group 763668oligopeptidase b
Group 763670prolyl endopeptidase
Group 763669prolyl oligopeptidase
Group 763683Uncharacterized protein
Group 763677Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763692Protease II
Group 763684Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763695Serine proteases of the peptidase family S9A
Group 763680Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763682Uncharacterized protein
Group 763722Uncharacterized protein
Group 763714prolyl endopeptidase
Group 763721Uncharacterized protein
Group 763703Peptidase S9 prolyl oligopeptidase active site
Group 763674Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763696Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763736S9 prolyl oligopeptidase active site domain protein
Group 763788Prolyl oligopeptidase family protein
Group 763756Prolyl oligopeptidase family protein
Group 763709Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763699Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763735Uncharacterized protein
Group 763739Uncharacterized protein
Group 763693Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763789-
Group 763673Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763697Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763704Uncharacterized protein
Group 763705Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763775gene
Group 763791-
Group 763799-
Group 763671Peptidase S9B dipeptidylpeptidase IV domain protein
Group 763694Peptidase S9 prolyl oligopeptidase active site domain protein
Group 763745Prolyl oligopeptidase family protein
Group 763760-
Group 763762