Entry YEAST01371 (MUS81_YEAST)

ESaccharomyces cerevisiae (strain ATCC 204508 / S288c)


General information

Organism
YEAST - Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Locus
Chromosome IV: 1246084..1247982

IDs and Cross-references

UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot MUS81_YEAST (Acc.: Q04149)
Refseq
Refseq logo NP_010674(Acc.:Refseq logo NP_010674.3Refseq logo GI: 398366551)
EntrezGene
Entrez logo 851994
NCBI
ncbi logo AAB64828.1, ncbi logo DAA12230.1
Other IDs
YDR386W, YDR386W

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
DNA binding (GO:0003677) IEA: GO_REF:002
nuclease activity (GO:0004518) IEA: GO_REF:002, GO_REF:037
endonuclease activity (GO:0004519) IEA: GO_REF:037
enzyme inhibitor activity (GO:0004857) IDA: PMID:25765656
protein binding (GO:0005515) IPI: PMID:11139495, PMID:17363897
hydrolase activity (GO:0016787) IEA: GO_REF:037
metal ion binding (GO:0046872) IEA: GO_REF:037
3'-flap endonuclease activity (GO:0048257) IBA: GO_REF:033

Cellular component
GO termEvidence and reference
nucleus (GO:0005634) IPI: PMID:10905349
IMP: PMID:10905349
IEA: GO_REF:037, GO_REF:039
nucleolus (GO:0005730) IEA: OMA_Fun:001
Holliday junction resolvase complex (GO:0048476) IDA: PMID:17363897

Biological process
GO termEvidence and reference
resolution of meiotic recombination intermediates (GO:0000712) IGI: PMID:18691964
double-strand break repair via break-induced replication (GO:0000727) IMP: PMID:23071463
IGI: PMID:23071463
DNA catabolic process, endonucleolytic (GO:0000737) IEA: OMA_Fun:001
DNA topological change (GO:0006265) IGI: PMID:11139495
DNA repair (GO:0006281) IGI: PMID:12032096
IEA: GO_REF:037
DNA recombination (GO:0006310) IEA: GO_REF:037
cellular response to DNA damage stimulus (GO:0006974) IMP: PMID:11139495
IEA: GO_REF:037
mitotic G2 DNA damage checkpoint (GO:0007095) IBA: GO_REF:033
reciprocal meiotic recombination (GO:0007131) IGI: PMID:11641278
replication fork processing (GO:0031297) IBA: GO_REF:033
intra-S DNA damage checkpoint (GO:0031573) IBA: GO_REF:033
negative regulation of helicase activity (GO:0051097) IDA: PMID:25765656
meiotic cell cycle (GO:0051321) IEA: GO_REF:037
nucleic acid phosphodiester bond hydrolysis (GO:0090305) IEA: GO_REF:108

Protein Sequence

MELSSNLKDL YIEWLQELVD GLTPKQEQLK IAYEKAKRNL QNAEGSFYYP TDLKKVKGIG    60
NTIIKRLDTK LRNYCKIHHI SPVEAPSLTQ TSSTRPPKRT TTALRSIVNS CENDKNEAPE   120
EKGTKKRKTR KYIPKKRSGG YAILLSLLEL NAIPRGVSKE QIIEVAGKYS DHCMTPNFST   180
KEFYGAWSSI AALKKHSLVL EEGRPKRYSL TEEGVELTKS LKTADGISFP KENEEPNEYS   240
VTRNESSEFT ANLTDLRGEY GKEEEPCDIN NTSFMLDITF QDLSTPQRLQ NNVFKNDRLN   300
SQTNISSHKL EEVSDDQTVP DSALKAKSTI KRRRYNGVSY ELWCSGDFEV FPIIDHREIK   360
SQSDREFFSR AFERKGMKSE IRQLALGDII WVAKNKNTGL QCVLNTIVER KRLDDLALSI   420
RDNRFMEQKN RLEKSGCEHK YYLIEETMSG NIGNMNEALK TALWVILVYY KFSMIRTCNS   480
DETVEKIHAL HTVISHHYSQ KDLIVIFPSD LKSKDDYKKV LLQFRREFER KGGIECCHNL   540
ECFQELMGKG DLKTVGELTI HVLMLVKGIS LEKAVAIQEI FPTLNKILMA YKTCSSEEEA   600
KLLMFNVLGD APGAKKITKS LSEKIYDAFG KL                                 632