Entry BOVIN02899 (F1MB07)

EBos taurus


General information

Description
DNA ligase 4 [Source:RefSeq peptide;Acc:NP_001178055]
Organism
BOVIN - Bos taurus
Locus
Chromosome 12: complement(87607577..87610312)
Protein Structures
pmp logo Protein Model Portal: F1MB07

IDs and Cross-references

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
nucleotide binding (GO:0000166) IEA: GO_REF:038
DNA binding (GO:0003677) IEA: GO_REF:002, GO_REF:107
DNA ligase activity (GO:0003909) IEA: GO_REF:002, GO_REF:107
DNA ligase (ATP) activity (GO:0003910) IBA: GO_REF:033
IEA: GO_REF:002, GO_REF:003, GO_REF:107
ATP binding (GO:0005524) IEA: GO_REF:002, GO_REF:038, GO_REF:107
protein C-terminus binding (GO:0008022) IEA: GO_REF:107, OMA_Fun:001
ligase activity (GO:0016874) IEA: GO_REF:038, GO_REF:107
metal ion binding (GO:0046872) IEA: OMA_Fun:001

Cellular component
GO termEvidence and reference
condensed chromosome (GO:0000793) IEA: GO_REF:107, OMA_Fun:001
nucleus (GO:0005634) IEA: GO_REF:107
nucleoplasm (GO:0005654) IEA: GO_REF:107
cytoplasm (GO:0005737) IBA: GO_REF:033
DNA-dependent protein kinase-DNA ligase 4 complex (GO:0005958) IBA: GO_REF:033
IEA: GO_REF:107
nuclear lumen (GO:0031981) IEA: OMA_Fun:001
DNA ligase IV complex (GO:0032807) IBA: GO_REF:033
IEA: GO_REF:107
cytoplasmic ribonucleoprotein granule (GO:0036464) IEA: GO_REF:107
nonhomologous end joining complex (GO:0070419) IEA: GO_REF:107

Biological process
GO termEvidence and reference
single strand break repair (GO:0000012) IEA: GO_REF:107, OMA_Fun:001
in utero embryonic development (GO:0001701) IEA: GO_REF:107, OMA_Fun:001
pro-B cell differentiation (GO:0002328) IEA: GO_REF:107, OMA_Fun:001
DNA replication (GO:0006260) IEA: GO_REF:038
DNA ligation (GO:0006266) IEA: GO_REF:107
DNA repair (GO:0006281) IEA: GO_REF:002, GO_REF:038, GO_REF:107
nucleotide-excision repair, DNA gap filling (GO:0006297) IBA: GO_REF:033
IEA: GO_REF:107
double-strand break repair (GO:0006302) IEA: GO_REF:107
double-strand break repair via nonhomologous end joining (GO:0006303) IBA: GO_REF:033
IEA: GO_REF:107
DNA recombination (GO:0006310) IEA: GO_REF:002, GO_REF:038
cellular response to DNA damage stimulus (GO:0006974) IEA: GO_REF:038
cell cycle (GO:0007049) IEA: OMA_Fun:001
central nervous system development (GO:0007417) IEA: GO_REF:107, OMA_Fun:001
cell proliferation (GO:0008283) IEA: GO_REF:107, OMA_Fun:001
response to X-ray (GO:0010165) IEA: GO_REF:107, OMA_Fun:001
response to ionizing radiation (GO:0010212) IEA: GO_REF:107
response to gamma radiation (GO:0010332) IEA: GO_REF:107, OMA_Fun:001
T cell differentiation in thymus (GO:0033077) IEA: GO_REF:107, OMA_Fun:001
V(D)J recombination (GO:0033151) IEA: GO_REF:107
immunoglobulin V(D)J recombination (GO:0033152) IBA: GO_REF:033
IEA: GO_REF:107
T cell receptor V(D)J recombination (GO:0033153) IEA: GO_REF:107, OMA_Fun:001
somatic stem cell population maintenance (GO:0035019) IEA: GO_REF:107, OMA_Fun:001
negative regulation of neuron apoptotic process (GO:0043524) IEA: GO_REF:107, OMA_Fun:001
isotype switching (GO:0045190) IEA: GO_REF:107, OMA_Fun:001
positive regulation of fibroblast proliferation (GO:0048146) IEA: GO_REF:107, OMA_Fun:001
positive regulation of neurogenesis (GO:0050769) IEA: GO_REF:107, OMA_Fun:001
DNA ligation involved in DNA recombination (GO:0051102) IEA: GO_REF:107, OMA_Fun:001
DNA ligation involved in DNA repair (GO:0051103) IBA: GO_REF:033
IEA: GO_REF:002, GO_REF:107
chromosome organization (GO:0051276) IEA: GO_REF:107, OMA_Fun:001
cell division (GO:0051301) IEA: OMA_Fun:001
neuron apoptotic process (GO:0051402) IEA: GO_REF:107, OMA_Fun:001
DNA biosynthetic process (GO:0071897) IEA: GO_REF:002
double-strand break repair via classical nonhomologous end joining (GO:0097680) IEA: GO_REF:107, OMA_Fun:001
positive regulation of chromosome organization (GO:2001252) IEA: GO_REF:107, OMA_Fun:001

Protein Sequence

MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFK AFLDSWRKFH NALHKNQKDV    60
TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RDGKDALKLL NYRTPTGTRG   120
DAGDFAMIAY FVLKPRCLQK GSLSIQQVND ILDSIASNNS AKRKDLMKKS VLQLITQSSA   180
LEQKWLIRMI VKDLKLGFSQ QTIFSIFHSD AAELHNVTTD LEKVCRQLHD PSVGLSDISI   240
TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYRY FSRNGYNYVD   300
QFGASPQEGS LTPFIHNAFK TEVLNCILDG EMMAYNPNTQ TFMQKGNKFD IKRMVEDSEL   360
QTCYCVFDVL MVNDKKLGHE TLRKRYEILN SVFTPVPGRI EIVQKTQAHT KKEVIDALNE   420
AIDKREEGIM VKHPLSIYKP DKRGEGWLKI KPEYVNGLMD ELDILIIGGY WGKGARGGMM   480
SHFLCAVSEK PPSGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKPFH RKAPPSNILC   540
GTEKPEVYIE PCNSVIVQVK ATEIVPSDMY KTGCTLRFPR IEKIREDKEW YECTSLEDLE   600
QLRGKACGKL ASRHLYLGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLS NVNRVSTVFE   660
DVEFCVMSGT SSHPKPDLEN RIAELGGYIV QNPGPDTYCV IAGSENIRVK NIISSDKHDV   720
VKPEWLLECF RTRSCVPWQP RFMIHMCPST KQHFAQEYDQ YGDSYFVDTD LHQLKEVFLG   780
IKNAGEQTPG EMSPVIADLE HRYSWASAPL SMFRHLTVYL DLYAVINDLS TRIKGARLAI   840
TALELRFHGA QVVSCLAEGV SHVIVGEDQS RVADLKAIRR TLKRKFKILQ ERWVTVSIDK   900
CELQEENRYL V                                                        911