Entry HUMAN28502 (TYRP1_HUMAN)

EHomo sapiens


General information

Description
tyrosinase related protein 1 [Source:HGNC Symbol;Acc:HGNC:12450]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 9: join(12693997..12694381, 12695515..12695837, 12698451..12698655, 12702271..12702438, (more...)

IDs and Cross-references

UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot TYRP1_HUMAN (Acc.: P17643)
Ensembl
Ensembl ENSG00000107165.12, Ensembl ENSP00000373570.4, Ensembl ENST00000388918.9
Refseq
Refseq logo NP_000541(Acc.:Refseq logo NP_000541.1)
EntrezGene
Entrez logo 7306
HGNC
TYRP1 tyrosinase related protein 1
NCBI
ncbi logo AAC15468, ncbi logo AAC41924, ncbi logo AAH52608, ncbi logo BAA11759, ncbi logo CAA35785, ncbi logo CAA35820, ncbi logo CAA43288

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
monooxygenase activity (GO:0004497) IEA: GO_REF:037
protein binding (GO:0005515) IPI: PMID:11441007, PMID:19841138
oxidoreductase activity (GO:0016491) IEA: GO_REF:002, GO_REF:037
protein homodimerization activity (GO:0042803) ISS: GO_REF:024
IEA: GO_REF:107
metal ion binding (GO:0046872) IEA: GO_REF:037, GO_REF:038
protein heterodimerization activity (GO:0046982) ISS: GO_REF:024
IEA: GO_REF:107

Cellular component
GO termEvidence and reference
endosome membrane (GO:0010008) IDA: PMID:19841138
membrane (GO:0016020) IEA: GO_REF:037, GO_REF:038
integral component of membrane (GO:0016021) IEA: GO_REF:037, GO_REF:038
clathrin-coated endocytic vesicle membrane (GO:0030669) IDA: PMID:19841138
melanosome membrane (GO:0033162) ISS: GO_REF:024
IEA: GO_REF:039, GO_REF:107
melanosome (GO:0042470) ISS: GO_REF:024
IEA: GO_REF:039, GO_REF:107

Biological process
GO termEvidence and reference
melanin metabolic process (GO:0006582) IEA: GO_REF:107, OMA_Fun:001
metabolic process (GO:0008152) IEA: GO_REF:002
melanocyte differentiation (GO:0030318) IEA: GO_REF:107, OMA_Fun:001
melanosome organization (GO:0032438) IEA: GO_REF:107, OMA_Fun:001
melanin biosynthetic process (GO:0042438) IEA: GO_REF:037, GO_REF:041
acetoacetic acid metabolic process (GO:0043438) IEA: GO_REF:107
pigmentation (GO:0043473) IEA: GO_REF:107
positive regulation of melanin biosynthetic process (GO:0048023) IMP: PMID:21996312
IEA: GO_REF:107
oxidation-reduction process (GO:0055114) IEA: GO_REF:037, GO_REF:108

Protein Sequence

MSAPKLLSLG CIFFPLLLFQ QARAQFPRQC ATVEALRSGM CCPDLSPVSG PGTDRCGSSS    60
GRGRCEAVTA DSRPHSPQYP HDGRDDREVW PLRFFNRTCH CNGNFSGHNC GTCRPGWRGA   120
ACDQRVLIVR RNLLDLSKEE KNHFVRALDM AKRTTHPLFV IATRRSEEIL GPDGNTPQFE   180
NISIYNYFVW THYYSVKKTF LGVGQESFGE VDFSHEGPAF LTWHRYHLLR LEKDMQEMLQ   240
EPSFSLPYWN FATGKNVCDI CTDDLMGSRS NFDSTLISPN SVFSQWRVVC DSLEDYDTLG   300
TLCNSTEDGP IRRNPAGNVA RPMVQRLPEP QDVAQCLEVG LFDTPPFYSN STNSFRNTVE   360
GYSDPTGKYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF VLLHTFTDAV FDEWLRRYNA   420
DISTFPLENA PIGHNRQYNM VPFWPPVTNT EMFVTAPDNL GYTYEIQWPS REFSVPEIIA   480
IAVVGALLLV ALIFGTASYL IRARRSMDEA NQPLLTDQYQ CYAEEYEKLQ NPNQSVV      537