Entry HUMAN01185 (NEXN_HUMAN)

EHomo sapiens


General information

Description
nexilin F-actin binding protein [Source:HGNC Symbol;Acc:HGNC:29557]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 1: join(77916107..77916133, 77917566..77917757, 77917960..77918038, 77918125..77918273, (more...)

IDs and Cross-references

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
actin binding (GO:0003779) IEA: GO_REF:037
structural constituent of muscle (GO:0008307) IMP: PMID:19881492
actin filament binding (GO:0051015) IDA: PMID:15823560

Cellular component
GO termEvidence and reference
cytoplasm (GO:0005737) IEA: GO_REF:037
cytoskeleton (GO:0005856) IEA: GO_REF:037, GO_REF:039
adherens junction (GO:0005912) IEA: GO_REF:039
focal adhesion (GO:0005925) IDA: PMID:21423176
Z disc (GO:0030018) ISS: GO_REF:024
IBA: GO_REF:033
IEA: GO_REF:039
cell junction (GO:0030054) IEA: GO_REF:037

Biological process
GO termEvidence and reference
regulation of cell migration (GO:0030334) IDA: PMID:15823560
cardiac muscle fiber development (GO:0048739) IBA: GO_REF:033
regulation of cytoskeleton organization (GO:0051493) IEP: PMID:15823560

Protein Sequence

MNDISQKAEI LLSSSKPVPK TYVPKLGKGD VKDKFEAMQR AREERNQRRS RDEKQRRKEQ    60
YIREREWNRR KQEIKEMLAS DDEEDVSSKV EKAYVPKLTG TVKGRFAEME KQRQEEQRKR   120
TEEERKRRIE QDMLEKRKIQ RELAKRAEQI EDINNTGTES ASEEGDDSLL ITVVPVKSYK   180
TSGKMKKNFE DLEKEREEKE RIKYEEDKRI RYEEQRPSLK EAKCLSLVMD DEIESEAKKE   240
SLSPGKLKLT FEELERQRQE NRKKQAEEEA RKRLEEEKRA FEEARRQMVN EDEENQDTAK   300
IFKGYRPGKL KLSFEEMERQ RREDEKRKAE EEARRRIEEE KKAFAEARRN MVVDDDSPEM   360
YKTISQEFLT PGKLEINFEE LLKQKMEEEK RRTEEERKHK LEMEKQEFEQ LRQEMGEEEE   420
ENETFGLSRE YEELIKLKRS GSIQAKNLKS KFEKIGQLSE KEIQKKIEEE RARRRAIDLE   480
IKEREAENFH EEDDVDVRPA RKSEAPFTHK VNMKARFEQM AKAREEEEQR RIEEQKLLRM   540
QFEQREIDAA LQKKREEEEE EEGSIMNGST AEDEEQTRSG APWFKKPLKN TSVVDSEPVR   600
FTVKVTGEPK PEITWWFEGE ILQDGEDYQY IERGETYCLY LPETFPEDGG EYMCKAVNNK   660
GSAASTCILT IESKN                                                    675