Entry HUMAN22710 (TM10A_HUMAN)

EHomo sapiens


General information

Description
tRNA methyltransferase 10A [Source:HGNC Symbol;Acc:HGNC:28403]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 4: join(complement(99559154..99559338), complement(99558049..99558211), (more...)
Protein Structures
pmp logo Protein Model Portal: V9HVY8

IDs and Cross-references

UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot TM10A_HUMAN (Acc.: Q8TBZ6)
UniProtKB/TrEMBL
UniProtKB/TrEMBL V9HVY8
Ensembl
Ensembl ENSG00000145331.13, Ensembl ENSP00000378343.3, Ensembl ENST00000394877.7
Refseq
Refseq logo NP_001128137(Acc.:Refseq logo NP_001128137.1)
EntrezGene
Entrez logo 93587
HGNC
TRMT10A tRNA methyltransferase 10A
NCBI
ncbi logo AAD21019, ncbi logo AAH28373, ncbi logo ACF94495, ncbi logo BAG36324, ncbi logo EAX06104, ncbi logo EAX06105

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
tRNA binding (GO:0000049) IDA: PMID:25053765
RNA binding (GO:0003723) HDA: PMID:22658674
methyltransferase activity (GO:0008168) IEA: GO_REF:002, GO_REF:037, GO_REF:038
tRNA (guanine-N1-)-methyltransferase activity (GO:0009019) IDA: PMID:23042678
transferase activity (GO:0016740) IEA: GO_REF:037, GO_REF:038
tRNA (guanine(9)-N(1))-methyltransferase activity (GO:0052905) IEA: GO_REF:003

Cellular component
GO termEvidence and reference
nucleus (GO:0005634) IDA: PMID:24204302
IEA: GO_REF:037, GO_REF:039
nucleoplasm (GO:0005654) IDA: GO_REF:052
nucleolus (GO:0005730) IDA: PMID:24204302, GO_REF:052
IEA: GO_REF:039
cytoplasm (GO:0005737) IEA: OMA_Fun:001
cytosol (GO:0005829) IDA: PMID:23042678, GO_REF:052
actin cytoskeleton (GO:0015629) IDA: GO_REF:052
extracellular exosome (GO:0070062) HDA: PMID:19056867

Biological process
GO termEvidence and reference
signal transduction (GO:0007165) IEA: OMA_Fun:001
tRNA methylation (GO:0030488) IDA: PMID:25053765
methylation (GO:0032259) IEA: GO_REF:037, GO_REF:038, GO_REF:108

Protein Sequence

MSSEMLPAFI ETSNVDKKQG INEDQEESQK PRLGEGCEPI SKRQMKKLIK QKQWEEQREL    60
RKQKRKEKRK RKKLERQCQM EPNSDGHDRK RVRRDVVHST LRLIIDCSFD HLMVLKDIKK   120
LHKQIQRCYA ENRRALHPVQ FYLTSHGGQL KKNMDENDKG WVNWKDIHIK PEHYSELIKK   180
EDLIYLTSDS PNILKELDES KAYVIGGLVD HNHHKGLTYK QASDYGINHA QLPLGNFVKM   240
NSRKVLAVNH VFEIILEYLE TRDWQEAFFT ILPQRKGAVP TDKACESASH DNQSVRMEEG   300
GSDSDSSEEE YSRNELDSPH EEKQDKENHT ESTVNSLPH                          339