Entry HUMAN05067 (CCND1_HUMAN)

EHomo sapiens


General information

Description
cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 11: join(69641314..69641511, 69643031..69643246, 69643832..69643991, 69647994..69648142, (more...)
Protein Structures
pmp logo Protein Model Portal: Q6FI00

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
transcription corepressor activity (GO:0003714) IDA: PMID:16569215, PMID:18417529
protein kinase activity (GO:0004672) IEA: GO_REF:107
cyclin-dependent protein serine/threonine kinase activity (GO:0004693) EXP: PMID:9190208
protein binding (GO:0005515) IPI: PMID:7568034, PMID:8756624, PMID:9106657, PMID:9840943, PMID:15232106, PMID:16461912, PMID:16864783, PMID:17254966, PMID:17334399, PMID:17517622, PMID:19237565, PMID:19409388, PMID:19412162, PMID:19470470, PMID:20439707, PMID:21242975, PMID:21516116, PMID:21952639, PMID:21988832, PMID:23455922, PMID:24218572, PMID:24855949, PMID:25241761, PMID:25416956, PMID:25910212, PMID:26496610, PMID:27107012
transcription factor binding (GO:0008134) IPI: PMID:16569215, PMID:19124461
kinase activity (GO:0016301) IEA: GO_REF:107
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) IEA: GO_REF:107
enzyme binding (GO:0019899) IPI: PMID:19412162
protein kinase binding (GO:0019901) IPI: PMID:8114739, PMID:19124461
IEA: GO_REF:107
protein complex binding (GO:0032403) IEA: GO_REF:107
histone deacetylase binding (GO:0042826) IPI: PMID:18417529
proline-rich region binding (GO:0070064) IDA: PMID:19124461

Cellular component
GO termEvidence and reference
cyclin-dependent protein kinase holoenzyme complex (GO:0000307) IDA: PMID:8114739, PMID:17420273
IEA: GO_REF:107
intracellular (GO:0005622) IDA: GO_REF:054
nucleus (GO:0005634) IDA: PMID:11793365
IEA: GO_REF:002, GO_REF:037, GO_REF:039, GO_REF:107
nucleoplasm (GO:0005654) IDA: GO_REF:052
cytoplasm (GO:0005737) IEA: GO_REF:037, GO_REF:039, GO_REF:107
bicellular tight junction (GO:0005923) IEA: GO_REF:107
membrane (GO:0016020) IEA: GO_REF:037, GO_REF:039
transcriptional repressor complex (GO:0017053) IDA: PMID:16569215, PMID:18417529

Biological process
GO termEvidence and reference
G1/S transition of mitotic cell cycle (GO:0000082) IDA: PMID:19412162
TAS: PMID:18483258
IEA: GO_REF:107
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) IDA: PMID:16569215, PMID:18417529
re-entry into mitotic cell cycle (GO:0000320) IEA: GO_REF:107
liver development (GO:0001889) IEA: GO_REF:107
positive regulation of protein phosphorylation (GO:0001934) IDA: PMID:8114739
transcription, DNA-templated (GO:0006351) IEA: GO_REF:037
regulation of transcription, DNA-templated (GO:0006355) IEA: GO_REF:037
protein phosphorylation (GO:0006468) IEA: GO_REF:107
cellular response to DNA damage stimulus (GO:0006974) IDA: PMID:19412162
IEA: GO_REF:037
cell cycle (GO:0007049) IEA: GO_REF:002, GO_REF:037
lactation (GO:0007595) IEA: GO_REF:107
positive regulation of cell proliferation (GO:0008284) IEA: GO_REF:107
tissue development (GO:0009888) IEA: OMA_Fun:001
cellular process (GO:0009987) IEA: OMA_Fun:001
response to organic substance (GO:0010033) IEA: GO_REF:107
response to iron ion (GO:0010039) IEA: GO_REF:107
response to X-ray (GO:0010165) IEA: GO_REF:107
response to organonitrogen compound (GO:0010243) IEA: GO_REF:107
positive regulation of G2/M transition of mitotic cell cycle (GO:0010971) IDA: PMID:19124461
response to organic cyclic compound (GO:0014070) IEA: GO_REF:107
Wnt signaling pathway (GO:0016055) IEA: GO_REF:107
negative regulation of Wnt signaling pathway (GO:0030178) IEA: GO_REF:107
negative regulation of epithelial cell differentiation (GO:0030857) IEA: GO_REF:107
endoplasmic reticulum unfolded protein response (GO:0030968) IEA: GO_REF:107
animal organ regeneration (GO:0031100) IEA: GO_REF:107
mitotic G1 DNA damage checkpoint (GO:0031571) IDA: PMID:19412162
response to magnesium ion (GO:0032026) IEA: GO_REF:107
response to estradiol (GO:0032355) IEA: GO_REF:107
developmental process (GO:0032502) IEA: OMA_Fun:001
response to vitamin E (GO:0033197) IEA: GO_REF:107
Leydig cell differentiation (GO:0033327) IEA: GO_REF:107
mammary gland epithelial cell proliferation (GO:0033598) IEA: GO_REF:107
positive regulation of mammary gland epithelial cell proliferation (GO:0033601) IEA: GO_REF:107
response to drug (GO:0042493) IEP: PMID:18291362
IEA: GO_REF:107
response to estrogen (GO:0043627) IEA: GO_REF:107
response to leptin (GO:0044321) IDA: PMID:17344214
fat cell differentiation (GO:0045444) IEA: GO_REF:107
response to ethanol (GO:0045471) IEA: GO_REF:107
positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737) IDA: PMID:8114739
regulation of protein kinase activity (GO:0045859) IEA: GO_REF:108
animal organ development (GO:0048513) IEA: OMA_Fun:001
response to steroid hormone (GO:0048545) IEA: GO_REF:107
cell division (GO:0051301) IEA: GO_REF:037
response to glucocorticoid (GO:0051384) IEA: GO_REF:107
response to corticosterone (GO:0051412) IEA: GO_REF:107
response to calcium ion (GO:0051592) IEA: GO_REF:107
regulation of cell cycle (GO:0051726) IEA: GO_REF:107
canonical Wnt signaling pathway (GO:0060070) IEA: GO_REF:107
mammary gland alveolus development (GO:0060749) IEA: GO_REF:107
response to UV-A (GO:0070141) IDA: PMID:18483258
negative regulation of cell cycle arrest (GO:0071157) IDA: PMID:19124461
cellular response to organic substance (GO:0071310) IEA: GO_REF:107
liver regeneration (GO:0097421) IEA: GO_REF:107
regulation of G1/S transition of mitotic cell cycle (GO:2000045) IEA: GO_REF:107

Protein Sequence

MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV    60
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT   120
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK   180
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD   240
PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI        295