Entry HUMAN03065 (LOX5_HUMAN)

EHomo sapiens


General information

Description
arachidonate 5-lipoxygenase [Source:HGNC Symbol;Acc:HGNC:435]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 10: join(45374280..45374429, 45382483..45382681, 45395855..45395936, 45412191..45412313, (more...)

IDs and Cross-references

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
arachidonate 5-lipoxygenase activity (GO:0004051) IDA: PMID:21233389
TAS: PMID:2829172
IEA: GO_REF:003
iron ion binding (GO:0005506) IDA: PMID:21233389
IEA: GO_REF:002
protein binding (GO:0005515) IPI: PMID:11297527, PMID:11785969, PMID:16924104, PMID:19233132, PMID:24860872, PMID:25416956, PMID:25910212
oxidoreductase activity (GO:0016491) IEA: GO_REF:037
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702) IEA: GO_REF:002
metal ion binding (GO:0046872) IEA: GO_REF:002, GO_REF:037
arachidonate 15-lipoxygenase activity (GO:0050473) IEA: OMA_Fun:001
dioxygenase activity (GO:0051213) IEA: GO_REF:037

Cellular component
GO termEvidence and reference
extracellular region (GO:0005576) IEA: OMA_Fun:001
extracellular space (GO:0005615) HDA: PMID:22664934
cell (GO:0005623) IEA: OMA_Fun:001
nucleus (GO:0005634) IEA: GO_REF:037, GO_REF:107
nuclear envelope (GO:0005635) IDA: PMID:19233132
nuclear envelope lumen (GO:0005641) IDA: PMID:8245774
nucleoplasm (GO:0005654) IDA: GO_REF:052
cytoplasm (GO:0005737) IEA: GO_REF:037, GO_REF:039, GO_REF:107
cytosol (GO:0005829) IDA: PMID:19233132
membrane (GO:0016020) IEA: GO_REF:037
nuclear matrix (GO:0016363) IDA: PMID:19233132
IEA: GO_REF:039
nuclear membrane (GO:0031965) IDA: PMID:8245774
IEA: GO_REF:039

Biological process
GO termEvidence and reference
leukotriene production involved in inflammatory response (GO:0002540) IEA: GO_REF:107
leukotriene metabolic process (GO:0006691) TAS: PMID:3422434
IEA: GO_REF:107
inflammatory response (GO:0006954) IEA: GO_REF:107
leukotriene biosynthetic process (GO:0019370) IDA: PMID:21233389
IEA: GO_REF:037, GO_REF:107
carboxylic acid metabolic process (GO:0019752) IEA: OMA_Fun:001
oxidation-reduction process (GO:0055114) IEA: GO_REF:002, GO_REF:037

Protein Sequence

MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE    60
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA   120
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL   180
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG   240
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP   300
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF   360
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG   420
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE   480
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL   540
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW   600
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY   660
YYLSPDRIPN SVAI                                                     674