List of all proteins in the group
Allows comparison of IDs and descriptions
of all proteins in the OMA Group.
Display an MSA of all sequences in the group.
The MSA is created using the Mafft program.
The jalview applet allows for numerous
display and export options.
Display closely related groups
The close groups are made of the set of all
groups that are linked by at least one pair
of orthologs.
Note that not all pairs of proteins coming
from close groups are orthologous. If that
were the case, the two groups would have
been merged.
Display phyletic profile
The "Phyletic profile" displays OMA groups
that have similar patterns of presence/absence
across species. This can be useful to detect
proteins that have complementary function
(e.g. member of the same metabolic pathway).
Compare GO annotations
This function displays a table of all
Gene Ontology (GO) annotations on
proteins of the OMA group. This
allows to compare the annotations
and serves as an additional description
of this OMA group.
OMA fingerprint
The fingerprint is a subsequence that is specific to a
certain group in the current OMA release
Since the group number is specific to a release, this
is the best way to track a group across releases.
OMA

Keyword Protein Sequence Group Entry

OMA Group 189815

Dihydrofolate reductase
This group has 100 members: 100 [B]acteria
Fingerprint: IRRTIIA

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[B] Nocardia farcinicaNOCFA05029  UniProtKB/TrEMBL Q5YPL6  putative dihydrofolate reductase
[B] Rhodococcus sp. (strain RHA1)RHOSR02201  UniProtKB/TrEMBL Q0SEI0  Dihydrofolate reductase
[B] Bifidobacterium longumBIFLO01578  UniProtKB/TrEMBL C5EBA9  Dihydrofolate reductase
[B] Bifidobacterium longum (strain DJO10A)BIFLD01768  UniProtKB/TrEMBL B3DQJ7  Dihydrofolate reductase
[B] Bacteroides thetaiotaomicronBACTN02030  UniProtKB/TrEMBL Q8A638  Dihydrofolate reductase
[B] Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)PARD803623  UniProtKB/TrEMBL A6LIC1  Putative dihydrofolate reductase
[B] Lactobacillus salivarius subsp. salivarius (strain UCC118)LACS100690  UniProtKB/TrEMBL Q1WU16  Dihydrofolate reductase COG0262 [H] Dihydrofolate reductase
[B] Bartonella bacilliformis (strain ATCC 35685 / KC583)BARBK00838  UniProtKB/TrEMBL A1UTA4  Dihydrofolate reductase
[B] Bartonella henselaeBARHE01038  UniProtKB/TrEMBL Q6G2S9  Dihydrofolate reductase
[B] Bartonella quintanaBARQU00831  UniProtKB/TrEMBL Q6FZ92  Dihydrofolate reductase
[B] Bartonella tribocorum (strain CIP 105476 / IBS 506)BART101249  UniProtKB/TrEMBL A9IW81  Dihydrofolate reductase type III (EC 1.5.1.3)(P11045) ,InterPro; Dihydrofolate reductase hypothetical protein
[B] Rhodopseudomonas palustrisRHOPA03479  UniProtKB/TrEMBL Q6N448  dihydrofolate reductase
[B] Rhodopseudomonas palustris (strain BisB18)RHOPB03206  UniProtKB/TrEMBL Q211Y1  Dihydrofolate reductase
[B] Rhodopseudomonas palustris (strain TIE-1)RHOPT03936  UniProtKB/TrEMBL B3QEZ8  Dihydrofolate reductase
[B] Methylobacterium sp. (strain 4-46)METS401023  UniProtKB/TrEMBL B0UDD2  Dihydrofolate reductase
[B] Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)PARL102380  UniProtKB/TrEMBL A7HVX5  Dihydrofolate reductase
[B] Rhizobium etli (strain CFN 42 / ATCC 51251)RHIEC02730  UniProtKB/TrEMBL Q2K6G9  dihydrofolate reductase protein similar to folA (SMc01442) [Sinorhizobium meliloti] and BMEI0609 [Brucella melitensis] Similar to swissprot:Q92NQ7 Putative location:bacterial cytoplasm Psort-Score: 0.0994; go_function: oxidoreductase activity [goid 0016491]; go_function: dihydrofolate reductase activity [goid 0004146]; go_process: nucleotide biosynthesis [goid 0009165]; go_process: glycine biosynthesis [goid 0006545]
[B] Rhizobium etli (strain CIAT 652)RHIE602898  UniProtKB/TrEMBL B3PTQ3  Dihydrofolate reductase protein
[B] Rhizobium leguminosarum bv. trifolii (strain WSM2304)RHILW02504  UniProtKB/TrEMBL B5ZWE4  Dihydrofolate reductase
[B] Rhizobium leguminosarum bv. viciae (strain 3841)RHIL303245  UniProtKB/TrEMBL Q1ME83  putative dihydrofolate reductase similarity:fasta; with=UniProt:DYR_ECOLI (EMBL:AE016755); Shigella flexneri.; folA; Dihydrofolate reductase (EC 1.5.1.3).; length=159; id 40.244; 164 aa overlap; query 7-170; subject 3-159 similarity:fasta; with=UniProt:Q8UDS4_AGRT5 (EMBL:AE008121); Agrobacterium tumefaciens (strain C58/ATCC 33970).; folA; Dihydrofolate reductase (AGR_C_3708p).; length=175; id 53.179; 173 aa overlap; query 1-172; subject 1-173
[B] Hyphomonas neptunium (strain ATCC 15444)HYPNA00459  UniProtKB/TrEMBL Q0C500  Dihydrofolate reductase
[B] Maricaulis maris (strain MCS10)MARMM02019  UniProtKB/TrEMBL Q0AN20  Dihydrofolate reductase
[B] Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)MAGMM01312   BAE50130.1  Dihydrofolate reductase
[B] Rhodospirillum centenum (strain ATCC 51521 / SW)RHOCS01925  UniProtKB/TrEMBL B6INW3  Dihydrofolate reductase
[B] Novosphingobium aromaticivorans (strain DSM 12444)NOVAD03235  UniProtKB/TrEMBL Q2G376  Dihydrofolate reductase
[B] Sphingopyxis alaskensisSPHAL02332  UniProtKB/TrEMBL Q1GQK3  Dihydrofolate reductase
[B] Delftia acidovorans (strain DSM 14801 / SPH-1)DELAS04879  UniProtKB/TrEMBL A9BMQ5  Dihydrofolate reductase
[B] Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)NEIG101493  UniProtKB/TrEMBL Q5F669  Best Blastp Hit: sp|P04174|DYR_NEIGO dihydrofolate reductase >gi|66103|pir||RDNHD dihydrofolate reductase (EC 1.5.1.3) - Neisseria gonorrhoeae COG0262 Dihydrofolate reductase; FolA dihydrofolate reductase
[B] Neisseria gonorrhoeae (strain NCCP11945)NEIG202008  UniProtKB/TrEMBL B4RNR3  FolA
[B] Neisseria meningitidis serogroup ANEIMA01923  UniProtKB/Swiss-Prot DYR_NEIMA  Dihydrofolate reductase
[B] Neisseria meningitidis serogroup BNEIMB00285  UniProtKB/Swiss-Prot DYR_NEIMB  Dihydrofolate reductase
[B] Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18)NEIMF01678  UniProtKB/TrEMBL A1KVY2  Dihydrofolate reductase
[B] Aeromonas salmonicida (strain A449)AERS400835  UniProtKB/TrEMBL A4SJJ4  Dihydrofolate reductase
[B] Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)SACD200351  UniProtKB/TrEMBL Q21NW4  Dihydrofolate reductase
[B] Pseudoalteromonas atlantica (strain T6c / BAA-1087)PSEA603694  UniProtKB/TrEMBL Q15PF1  Dihydrofolate reductase
[B] Halorhodospira halophila (strain DSM 244 / SL1)HALHL02015  UniProtKB/TrEMBL A1WYQ0  Dihydrofolate reductase
[B] Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)CITK803224  UniProtKB/TrEMBL A8ALQ3  Putative uncharacterized protein
[B] Enterobacter sakazakii (strain ATCC BAA-894)ENTS803198  UniProtKB/TrEMBL A7MIB4  Putative uncharacterized protein
[B] Escherichia coli (strain 55989 / EAEC)ECO5500046  UniProtKB/TrEMBL B7L4H1  Dihydrofolate reductase
[B] Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)ECOLC03506  UniProtKB/TrEMBL B1IRC8  Dihydrofolate reductase
[B] Escherichia coli (strain DH10B)ECODH00044  UniProtKB/TrEMBL B1XC49  Dihydrofolate reductase
[B] Escherichia coli (strain K12)ECOLI00044  UniProtKB/Swiss-Prot DYR_ECOLI  Dihydrofolate reductase
[B] Escherichia coli (strain SE11)ECOSE00049  UniProtKB/TrEMBL B6HZ29  Dihydrofolate reductase
[B] Escherichia coli (strain SMS-3-5 / SECEC)ECOSM00050  UniProtKB/TrEMBL B1LFY2  Dihydrofolate reductase
[B] Escherichia coli (strain UTI89 / UPEC)ECOUT00054  UniProtKB/TrEMBL Q1RGF0  dihydrofolate reductase
[B] Escherichia coli O127:H6 (strain E2348/69 / EPEC)ECO2700047  UniProtKB/TrEMBL B7UI94  Dihydrofolate reductase
[B] Escherichia coli O139:H28 (strain E24377A / ETEC)ECO2400050  UniProtKB/TrEMBL A7ZHE1  Dihydrofolate reductase
[B] Escherichia coli O157:H7ECO5700051  UniProtKB/TrEMBL Q8XA18  Residues 1 to 159 of 159 are 99.37 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 Strain MG1655: B0048 dihydrofolate reductase type I; trimethoprim resistance
[B] Escherichia coli O157:H7 (strain EC4115 / EHEC)ECO5E00048  UniProtKB/TrEMBL B5YZ84  Dihydrofolate reductase
[B] Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)ECOLU00048  UniProtKB/TrEMBL B7N7S3  Dihydrofolate reductase
[B] Escherichia coli O1:K1 / APECECOK100043  UniProtKB/TrEMBL A1A797  dihydrofolate reductase
[B] Escherichia coli O45:K1 (strain S88 / ExPEC)ECO4500049  UniProtKB/TrEMBL B7MAH1  Dihydrofolate reductase
[B] Escherichia coli O6ECOL600056  UniProtKB/Swiss-Prot DYR_ECOL6  Dihydrofolate reductase
[B] Escherichia coli O6:K15:H31 (strain 536)ECOL500048  UniProtKB/TrEMBL Q0TLU1  dihydrofolate reductase
[B] Escherichia coli O7:K1 (strain IAI39 / ExPEC)ECO7I00049  UniProtKB/TrEMBL B7NHF2  Dihydrofolate reductase
[B] Escherichia coli O81 (strain ED1a)ECO8100046  UniProtKB/TrEMBL B7MNQ5  Dihydrofolate reductase
[B] Escherichia coli O9:H4 (strain HS)ECOHS00051  UniProtKB/TrEMBL A7ZW00  Dihydrofolate reductase
[B] Photorhabdus luminescens (subsp. laumondii)PHOLL00591  UniProtKB/TrEMBL Q7N8W0  dihydrofolate reductase
[B] Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)SALAR02800  UniProtKB/TrEMBL A9MQG5  Putative uncharacterized protein
[B] Salmonella agona (strain SL483)SALA400092  UniProtKB/TrEMBL B5F768  Dihydrofolate reductase
[B] Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67SALCH00081  UniProtKB/TrEMBL Q57TH3  IPR001796: Dihydrofolate reductase dihydrofolate reductase type I; trimethoprim resistance
[B] Salmonella dublin (strain CT_02021853)SALDC00083  UniProtKB/TrEMBL B5FI31  Dihydrofolate reductase
[B] Salmonella enteritidis PT4 (strain P125109)SALEP00084  UniProtKB/TrEMBL B5R1S5  Dihydrofolate reductase type I
[B] Salmonella gallinarum (strain 287/91 / NCTC 13346)SALG200084  UniProtKB/TrEMBL B5RGB9  Dihydrofolate reductase type I
[B] Salmonella heidelberg (strain SL476)SALHS00085  UniProtKB/TrEMBL B4TJ44  Dihydrofolate reductase
[B] Salmonella newport (strain SL254)SALNS00089  UniProtKB/TrEMBL B4T6L3  Dihydrofolate reductase
[B] Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)SALPB00111  UniProtKB/TrEMBL A9MYM1  Putative uncharacterized protein
[B] Salmonella paratyphi A (strain AKU_12601)SALPK00087  UniProtKB/TrEMBL B5BL24  Dihydrofolate reductase type I
[B] Salmonella paratyphi-aSALPA00080  UniProtKB/TrEMBL Q5PDE2  similar to Salmonella typhi CT18 dihydrofolate reductase type I dihydrofolate reductase type I
[B] Salmonella schwarzengrund (strain CVM19633)SALSV00095  UniProtKB/TrEMBL B4TWT3  Dihydrofolate reductase
[B] Salmonella typhiSALTI00089  UniProtKB/TrEMBL Q8Z9J9  Dihydrofolate reductase type I
[B] Salmonella typhimuriumSALTY00085  UniProtKB/TrEMBL C9X680  similar to Escherichia coli dihydrofolate reductase type I; trimethoprim resistance (AAC73159.1) dihydrofolate reductase type I
[B] Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)SHIB300034  UniProtKB/TrEMBL B2U256  Dihydrofolate reductase
[B] Shigella boydii serotype 4 (strain Sb227)SHIBS00034  UniProtKB/TrEMBL Q326I5  trimethoprim resistance; Code: H; COG: COG0262 dihydrofolate reductase type I
[B] Shigella dysenteriae serotype 1 (strain Sd197)SHIDS00061  UniProtKB/TrEMBL Q32K48  trimethoprim resistance; Code: H; COG: COG0262 dihydrofolate reductase type I
[B] Shigella flexneriSHIFL00044   NP_706004.1  Residues 1 to 140 of 140 are 100 pct identical to residues 20 to 159 of a 159 aa protein from Escherichia coli K12 ref: NP_414590.1 dihydrofolate reductase type I; trimethoprim resistance
[B] Shigella flexneri serotype 5b (strain 8401)SHIF800039  UniProtKB/TrEMBL Q0T8E7  dihydrofolate reductase type I Code: H; COG: COG0262
[B] Shigella sonnei (strain Ss046)SHISS00046  UniProtKB/TrEMBL Q3Z5W1  trimethoprim resistance; Code: H; COG: COG0262 dihydrofolate reductase type I
[B] Sodalis glossinidius (strain morsitans)SODGM00414  UniProtKB/TrEMBL Q2NVX9  dihydrofolate reductase
[B] Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)YERE800587  UniProtKB/TrEMBL A1JJF1  Dihydrofolate reductase
[B] Yersinia pestisYERPE00456  UniProtKB/TrEMBL A6BV19  Dihydrofolate reductase
[B] Yersinia pestis (biovar Antiqua strain Antiqua)YERPA03851  UniProtKB/TrEMBL Q1C0I2  Dihydrofolate reductase
[B] Yersinia pestis (biovar Antiqua strain Nepal516)YERPN00344  UniProtKB/TrEMBL Q1CMT9  Dihydrofolate reductase
[B] Yersinia pestis (strain Pestoides F)YERPP02971  UniProtKB/TrEMBL A4TQE3  Dihydrofolate reductase
[B] Yersinia pestis bv. Antiqua (strain Angola)YERPG00660  UniProtKB/TrEMBL A9QZZ6  Dihydrofolate reductase
[B] Yersinia pseudotuberculosisYERPS00623  UniProtKB/TrEMBL Q66ER3  Dihydrofolate reductase type I; trimethoprim resistance
[B] Yersinia pseudotuberculosis (serotype O:1b / strain IP 31758)YERP303380  UniProtKB/TrEMBL A7FMC6  Dihydrofolate reductase
[B] Yersinia pseudotuberculosis serotype IB (strain PB1/+)YERPB00629  UniProtKB/TrEMBL B2K483  Dihydrofolate reductase region
[B] Yersinia pseudotuberculosis serotype O:3 (strain YPIII)YERPY03508  UniProtKB/TrEMBL B1JKY8  Dihydrofolate reductase
[B] Methylococcus capsulatusMETCA02560  UniProtKB/TrEMBL Q603S1  identified by similarity to SP:P11045; match to protein family HMM PF00186 dihydrofolate reductase
[B] Actinobacillus succinogenes (strain ATCC 55618 / 130Z)ACTSZ00703  UniProtKB/TrEMBL A6VM90  Dihydrofolate reductase
[B] Pseudomonas aeruginosaPSEAE00350  UniProtKB/TrEMBL A3LHF9  Dihydrofolate reductase
[B] Pseudomonas aeruginosa (strain LESB58)PSEA800346  UniProtKB/TrEMBL B7V2R3  Dihydrofolate reductase
[B] Pseudomonas aeruginosa (strain UCBPP-PA14)PSEAB00364  UniProtKB/TrEMBL Q02U65  dihydrofolate reductase
[B] Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)PSEF505787  UniProtKB/TrEMBL Q4K492  identified by match to protein family HMM PF00186 dihydrofolate reductase
[B] Pseudomonas putida (strain F1 / ATCC 700007)PSEP104941  UniProtKB/TrEMBL A5WAG5  Dihydrofolate reductase
[B] Pseudomonas putida (strain GB-1)PSEPG05137  UniProtKB/TrEMBL B0KN86  Dihydrofolate reductase unknown EC_number=1.5.1.3 PFAM: dihydrofolate reductase region KEGG: pen:PSEEN0273 dihydrofolate reductase type I, trimethoprim resistance
[B] Pseudomonas putida (strain KT2440)PSEPK05022  UniProtKB/TrEMBL Q88CP8  identified by match to PFAM protein family HMM PF00186 dihydrofolate reductase
[B] Xanthomonas axonopodis (pv. citri)XANAC00831  UniProtKB/TrEMBL Q8PP44  identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark dihydrofolate reductase type III
[B] Ruthia magnifica subsp. Calyptogena magnificaRUTMC00920  UniProtKB/TrEMBL A1AXR7  Dihydrofolate reductase