List of all proteins in the group
Allows comparison of IDs and descriptions
of all proteins in the OMA Group.
Display an MSA of all sequences in the group.
The MSA is created using the Mafft program.
The jalview applet allows for numerous
display and export options.
Display closely related groups
The close groups are made of the set of all
groups that are linked by at least one pair
of orthologs.
Note that not all pairs of proteins coming
from close groups are orthologous. If that
were the case, the two groups would have
been merged.
Display phyletic profile
The "Phyletic profile" displays OMA groups
that have similar patterns of presence/absence
across species. This can be useful to detect
proteins that have complementary function
(e.g. member of the same metabolic pathway).
Compare GO annotations
This function displays a table of all
Gene Ontology (GO) annotations on
proteins of the OMA group. This
allows to compare the annotations
and serves as an additional description
of this OMA group.
OMA fingerprint
The fingerprint is a subsequence that is specific to a
certain group in the current OMA release
Since the group number is specific to a release, this
is the best way to track a group across releases.
OMA

Keyword Protein Sequence Group Entry

OMA Group 259989

Phosphoribosyl-ATP pyrophosphatase
This group has 49 members: 49 [B]acteria
Fingerprint: VWMAAEY

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[B] Corynebacterium diphtheriaeCORDI01223  UniProtKB/Swiss-Prot HIS2_CORDI  Similar to Corynebacterium glutamicum phosphoribosyl-ATP pyrophosphatase HisE SWALL:HIS2_CORGL (SWALL:Q9Z471) (87 aa) fasta scores: E(): 3e-23, 73.56% id in 87 aa, to the C-terminal region of Bacillus subtilis histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI or HisIE SWALL:HIS2_BACSU (SWALL:O34912) (209 aa) fasta scores: E(): 0.023, 32.53% id in 83 aa, and to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI or HisIE or B2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 0.08, 38.88% id in 72 aa. Note: Although in E. coli and B. subtillis HisE is part of a bifunctional protein (together with HisI), it seems that in C. diphtheriae they are separate proteins phosphoribosyl-ATP pyrophosphatase
[B] Corynebacterium efficiensCOREF01589  UniProtKB/Swiss-Prot HIS2_COREF  similar to AX064095-1|CAC25288.1| percent identity: 86 in 90 aa phosphoribosyl-ATP pyrophosphatase
[B] Corynebacterium glutamicumCORGL02117  UniProtKB/Swiss-Prot HIS2_CORGL  Phosphoribosyl-ATP pyrophosphatase
[B] Corynebacterium glutamicum (strain R)CORGB01594  UniProtKB/Swiss-Prot HIS2_CORGB  Hypothetical protein
[B] Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)CORU701027  UniProtKB/TrEMBL B1VDU6  Phosphoribosyl-ATP pyrophosphatase
[B] Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)MYCA902107  UniProtKB/Swiss-Prot HIS2_MYCA9  Probable phosphoribosyl-ATP pyrophosphatase
[B] Mycobacterium avium (strain 104)MYCA102237  UniProtKB/Swiss-Prot HIS2_MYCA1  phosphoribosyl-ATP pyrophosphohydrolase identified by match to protein family HMM PF01503
[B] Mycobacterium paratuberculosisMYCPA01830  UniProtKB/Swiss-Prot HIS2_MYCPA  HisI
[B] Mycobacterium gilvum (strain PYR-GCK)MYCGI02970  UniProtKB/Swiss-Prot HIS2_MYCGI  phosphoribosyl-ATP pyrophosphatase PFAM: phosphoribosyl-ATP pyrophosphohydrolase KEGG: mmc:Mmcs_3146 phosphoribosyl-ATP pyrophosphohydrolase
[B] Mycobacterium lepraeMYCLE01302  UniProtKB/Swiss-Prot HIS2_MYCLE  Highly similar to several phosphoribosyl-ATP pyrophosphatases (EC 3.6.1.31) involved in histidine biosynthesis, including: Sulfolobus solfataricus HisE SW:HIS2_SULSO (O33776) (94 aa); Fasta score E(): 0.00013, 32.5% identity in 83 aa overlap and Mycobacterium tuberculosis RV2122C SW:HIS2_MYCTU (O33257) (93 aa); Fasta score E(): 2.5e-31, 86.0% identity in 93 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase. phosphoribosyl-ATP pyrophosphatase
[B] Mycobacterium leprae (strain Br4923)MYCLB01295  UniProtKB/Swiss-Prot HIS2_MYCLB  Phosphoribosyl-ATP pyrophosphatase
[B] Mycobacterium marinum (strain ATCC BAA-535 / M)MYCMM03046  UniProtKB/Swiss-Prot HIS2_MYCMM  Phosphoribosyl-AMP pyrophosphatase HisE
[B] Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)MYCS203935  UniProtKB/Swiss-Prot HIS2_MYCS2  Phosphoribosyl-ATP pyrophosphohydrolase
[B] Mycobacterium sp. (strain JLS)MYCSJ03094  UniProtKB/Swiss-Prot HIS2_MYCSJ  phosphoribosyl-ATP pyrophosphohydrolase PFAM: phosphoribosyl-ATP pyrophosphohydrolase KEGG: mmc:Mmcs_3146 phosphoribosyl-ATP pyrophosphohydrolase
[B] Mycobacterium sp. (strain KMS)MYCSK03135  UniProtKB/Swiss-Prot HIS2_MYCSK  phosphoribosyl-ATP pyrophosphohydrolase PFAM: phosphoribosyl-ATP pyrophosphohydrolase KEGG: mmc:Mmcs_3146 phosphoribosyl-ATP pyrophosphohydrolase
[B] Mycobacterium sp. (strain MCS)MYCSS03110  UniProtKB/Swiss-Prot HIS2_MYCSS  Phosphoribosyl-ATP pyrophosphohydrolase
[B] Mycobacterium bovisMYCBO02138  UniProtKB/Swiss-Prot HIS2_MYCBO  Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 93 aa overlap). Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI. Probable phosphoribosyl-AMP pyrophosphatase HisE
[B] Mycobacterium bovis (strain BCG / Paris 1173P2)MYCBP02112  UniProtKB/Swiss-Prot HIS2_MYCBP  Probable phosphoribosyl-AMP pyrophosphatase HisE
[B] Mycobacterium tuberculosisMYCTU03279  UniProtKB/Swiss-Prot HIS2_MYCTU  Phosphoribosyl-ATP pyrophosphatase
[B] Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)MYCTA02157  UniProtKB/Swiss-Prot HIS2_MYCTA  Putative phosphoribosyl-AMP pyrophosphatase HisE
[B] Mycobacterium tuberculosis (strain F11)MYCTF02077  UniProtKB/TrEMBL A5WP96  phosphoribosyl-AMP pyrophosphatase hisE Mapped to H37Rv Rv2122c
[B] Mycobacterium ulcerans (strain Agy99)MYCUA01911  UniProtKB/Swiss-Prot HIS2_MYCUA  phosphoribosyl-AMP pyrophosphatase HisE cytoplasmic protein thought to be involved in histidine biosynthesis.
[B] Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)MYCVP03356  UniProtKB/Swiss-Prot HIS2_MYCVP  phosphoribosyl-ATP pyrophosphohydrolase PFAM: phosphoribosyl-ATP pyrophosphohydrolase KEGG: mmc:Mmcs_3146 phosphoribosyl-ATP pyrophosphohydrolase
[B] Nocardia farcinicaNOCFA03189  UniProtKB/Swiss-Prot HIS2_NOCFA  putative phosphoribosyl-ATP pyrophosphatase
[B] Rhodococcus erythropolis (strain PR4 / NBRC 100887)RHOE403177  UniProtKB/Swiss-Prot HIS2_RHOE4  Phosphoribosyl-ATP pyrophosphatase
[B] Rhodococcus opacus (strain B4)RHOOB00593  UniProtKB/Swiss-Prot HIS2_RHOOB  Phosphoribosyl-ATP pyrophosphatase
[B] Rhodococcus sp. (strain RHA1)RHOSR00834  UniProtKB/Swiss-Prot HIS2_RHOSR  Phosphoribosyl-ATP diphosphatase
[B] Frankia sp. (strain CcI3)FRASC04192  UniProtKB/TrEMBL Q2J4X9  Phosphoribosyl-ATP pyrophosphohydrolase-like
[B] Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)CLAM301790  UniProtKB/Swiss-Prot HIS2_CLAM3  Phosphoribosyl-ATP pyrophosphatase
[B] Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667)CLAMS01945  UniProtKB/Swiss-Prot HIS2_CLAMS  Phosphoribosyl-ATP pyrophosphatase
[B] Leifsonia xyli (subsp. xyli)LEIXX00850  UniProtKB/Swiss-Prot HIS2_LEIXX  identified by sequence similarity phosphoribosyl-ATP pyrophosphatase
[B] Arthrobacter aurescens (strain TC1)ARTAT01740   ABM08649.1  Phosphoribosyl-ATP pyrophosphatase
[B] Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)ARTCA01656  UniProtKB/Swiss-Prot HIS2_ARTCA  Phosphoribosyl-ATP diphosphatase
[B] Arthrobacter sp. (strain FB24)ARTS201669   ABK03073.1  phosphoribosyl-ATP pyrophosphohydrolase PFAM: phosphoribosyl-ATP pyrophosphohydrolase KEGG: tfu:Tfu_0175 phosphoribosyl-ATP pyrophosphatase
[B] Kocuria rhizophila (strain ATCC 9341 / NBRC 12708 / DC2201)KOCRD01169  UniProtKB/Swiss-Prot HIS2_KOCRD  Phosphoribosyl-ATP pyrophosphatase
[B] Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / IFO 15589)RENSM02251  UniProtKB/TrEMBL A9WR64  Phosphoribosyl-ATP pyrophosphatase
[B] Salinispora arenicola (strain CNS-205)SALAI01815  UniProtKB/TrEMBL A8LY40  Phosphoribosyl-ATP pyrophosphohydrolase
[B] Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)SALTO01853  UniProtKB/TrEMBL A4X641  Phosphoribosyl-ATP pyrophosphatase
[B] Nocardioides sp. (strain BAA-499 / JS614)NOCSJ02389  UniProtKB/Swiss-Prot HIS2_NOCSJ  Phosphoribosyl-ATP pyrophosphohydrolase
[B] Propionibacterium acnesPROAC01402  UniProtKB/Swiss-Prot HIS2_PROAC  phosphoribosyl-ATP pyrophosphatase
[B] Saccharopolyspora erythraea (strain NRRL 23338)SACEN02176  UniProtKB/Swiss-Prot HIS2_SACEN  Phosphoribosyl-ATP pyrophosphatase
[B] Phytoplasma sp. (strain STRAWB1)STRAW06903  UniProtKB/Swiss-Prot HIS2_STRAW  Phosphoribosyl-ATP pyrophosphatase
[B] Streptomyces coelicolorSTRCO01423  UniProtKB/Swiss-Prot HIS2_STRCO  SC6D7A.02c, hisE, phosphoribosyl-ATP pyrophosphatase, len: 90 aa; similar to SW:HIS2_SULSO (EMBL:U82227) Sulfolobus solfataricus phosphoribosyl-ATP pyrophosphatase HisE (EC 3.6.1.31), 94 aa; fasta scores: opt: 175 z-score: 245.2 E(): 4e-06; 33.3% identity in 90 aa overlap and to SW:HIS2_MYCTU (EMBL:Z97559) Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphatase HisE (EC 3.6.1.31), 93 aa; fasta scores: opt: 336 z-score: 452.1 E(): 1.2e-17; 60.0% identity in 90 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase phosphoribosyl-ATP pyrophosphatase
[B] Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)STRGG05967  UniProtKB/Swiss-Prot HIS2_STRGG  Putative phosphoribosyl-ATP pyrophosphatase
[B] Thermobifida fusca (strain YX)THEFY00173  UniProtKB/Swiss-Prot HIS2_THEFY  phosphoribosyl-ATP pyrophosphatase
[B] Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083)BIFAA00792   BAF39575.1  phosphoribosyl-ATP pyrophosphatase Catalyzes the formation of 1-(5-phosphoribosyl)-AMPfrom 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis Orthologue of BL0752
[B] Bifidobacterium longumBIFLO00405  UniProtKB/Swiss-Prot HIS2_BIFLO  Phosphoribosyl-ATP pyrophosphatase
[B] Bifidobacterium longum (strain DJO10A)BIFLD00467  UniProtKB/Swiss-Prot HIS2_BIFLD  Phosphoribosyl-ATP pyrophosphohydrolase
[B] Salinibacter ruber (strain DSM 13855)SALRD00701  UniProtKB/Swiss-Prot HIS2_SALRD  phosphoribosyl-ATP pyrophosphohydrolase identified by match to protein family HMM PF01503