Entry HUMAN28448 (KANK1_HUMAN)

EHomo sapiens


General information

Description
KN motif and ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:HGNC:19309]
Organism
HUMAN - Homo sapiens
Locus
Chromosome 9: join(676973..677009, 710804..713464, 730051..730248, 731158..731266, 732378..732617, (more...)
Alternative splicing
HUMAN28449

IDs and Cross-references

UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot KANK1_HUMAN (Acc.: Q14678)
Ensembl
Ensembl ENSG00000107104.18, Ensembl ENSP00000371740.1, Ensembl ENST00000382303.5
Refseq
Refseq logo NP_055973(Acc.:Refseq logo NP_055973.2Refseq logo GI: 64464726)
EntrezGene
Entrez logo 23189
HGNC
KANK1 KN motif and ankyrin repeat domains 1
NCBI
ncbi logo AAH37495, ncbi logo BAA11489, ncbi logo CAH70388, ncbi logo CAM13084, ncbi logo EAW58821, ncbi logo EAW58822

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
protein binding (GO:0005515) IPI: PMID:16968744, PMID:18458160, PMID:19171758, PMID:19559006, PMID:26496610
beta-catenin binding (GO:0008013) IDA: PMID:16968744

Cellular component
GO termEvidence and reference
nucleus (GO:0005634) IDA: PMID:16968744
IEA: GO_REF:037, GO_REF:039
cytoplasm (GO:0005737) IDA: PMID:16968744
IEA: GO_REF:037, GO_REF:039
plasma membrane (GO:0005886) IDA: GO_REF:052
IEA: GO_REF:037
membrane (GO:0016020) IEA: GO_REF:037
ruffle membrane (GO:0032587) IDA: PMID:19559006
IEA: GO_REF:039
cell projection (GO:0042995) IEA: GO_REF:037

Biological process
GO termEvidence and reference
transcription, DNA-templated (GO:0006351) IEA: GO_REF:037
regulation of transcription, DNA-templated (GO:0006355) IEA: GO_REF:037
negative regulation of neuron projection development (GO:0010977) IDA: PMID:19171758
positive regulation of Wnt signaling pathway (GO:0030177) IDA: PMID:16968744
negative regulation of cell migration (GO:0030336) IMP: PMID:18458160
negative regulation of actin filament polymerization (GO:0030837) IDA: PMID:17996375, PMID:18458160
negative regulation of Rho protein signal transduction (GO:0035024) IMP: PMID:18458160
positive regulation of catenin import into nucleus (GO:0035413) IMP: PMID:16968744
negative regulation of insulin receptor signaling pathway (GO:0046627) IMP: PMID:18458160
positive regulation of wound healing (GO:0090303) IMP: PMID:22084092
negative regulation of substrate adhesion-dependent cell spreading (GO:1900025) IDA: PMID:19171758
negative regulation of ruffle assembly (GO:1900028) IDA: PMID:19171758
regulation of establishment of cell polarity (GO:2000114) IMP: PMID:22084092
negative regulation of lamellipodium morphogenesis (GO:2000393) IDA: PMID:19171758

Protein Sequence

MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD DIQKGNTIKR    60
LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN KQCPNFLIAR SQVTSTPISK   120
PPPPLETSLP FLTIPENRQL PPPSPQLPKH NLHVTKTLME TRRRLEQERA TMQMTPGEFR   180
RPRLASFGGM GTTSSLPSFV GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR   240
HSPLSSGIST PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ   300
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE EEEMETVEQS   360
TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS VAVGAEENMN DIVVYHRGSR   420
SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE ADKEIELQQQ TIESLKEKIY RLEVQLRETT   480
HDREMTKLKQ ELQAAGSRKK VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT   540
SVETNSVGIS CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC   600
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV NTEAVSQVEA   660
AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL STLDKQTSTQ TVETRTVAVG   720
EGRVKDINSS TKTRSIGVGT LLSGHSGFDR PSAVKTKESG VGQININDNY LVGLKMRTIA   780
CGPPQLTVGL TASRRSVGVG DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL   840
LAENYSELAE AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG   900
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL SPVNLTDDQI   960
AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN GGYETTSSDD SSSDESSSSE  1020
SDDECDVIEY PLEEEEEEED EDTRGMAEGH HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR  1080
ERYELSEKML SACNLLKNTI NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI  1140
AAFEAISPDV LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI  1200
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV KGLLACGADV  1260
NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND GSTALSIALE AGHKDIAVLL  1320
YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS FD                                1352