List of all proteins in the group
Allows comparison of IDs and descriptions
of all proteins in the OMA Group.
Display an MSA of all sequences in the group.
The MSA is created using the Mafft program.
The jalview applet allows for numerous
display and export options.
Display closely related groups
The close groups are made of the set of all
groups that are linked by at least one pair
of orthologs.
Note that not all pairs of proteins coming
from close groups are orthologous. If that
were the case, the two groups would have
been merged.
Display phyletic profile
The "Phyletic profile" displays OMA groups
that have similar patterns of presence/absence
across species. This can be useful to detect
proteins that have complementary function
(e.g. member of the same metabolic pathway).
Compare GO annotations
This function displays a table of all
Gene Ontology (GO) annotations on
proteins of the OMA group. This
allows to compare the annotations
and serves as an additional description
of this OMA group.
OMA fingerprint
The fingerprint is a subsequence that is specific to a
certain group in the current OMA release
Since the group number is specific to a release, this
is the best way to track a group across releases.
OMA

Keyword Protein Sequence Group Entry

OMA Group 188687

2-oxoglutarate dehydrogenase E1 component
This group has 43 members: 38 [E]ukaryota 5 [B]acteria
Fingerprint: WIRRRFE

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[E] Homo sapiensHUMAN08637  Ensembl ENSP00000414662   -
[E] Pan troglodytesPANTR09747  Ensembl ENSPTRP00000032714   -
[E] Pongo pygmaeus abeliiPONAB19039  Ensembl ENSPPYP00000019712  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).
[E] Macaca mulattaMACMU04918  Ensembl ENSMMUP00000003569   -
[E] Ochotona princepsOCHPR07860  Ensembl ENSOPRP00000010564   -
[E] Mus musculusMOUSE07451  UniProtKB/Swiss-Prot ODO1_MOUSE  oxoglutarate dehydrogenase (lipoamide)
[E] Rattus norvegicusRATNO22314  Ensembl ENSRNOP00000054023  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase). [Source:UniProtKB/Swiss-Prot;Acc:Q5XI78]
[E] Loxodonta africanaLOXAF10288  Ensembl ENSLAFP00000011489   -
[E] Tursiops truncatusTURTR13206  Ensembl ENSTTRP00000013985   -
[E] Bos taurusBOVIN03147  UniProtKB/Swiss-Prot ODO1_BOVIN  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase)
[E] Pteropus vampyrusPTEVA06999  Ensembl ENSPVAP00000001042   -
[E] Erinaceus europaeusERIEU09019  Ensembl ENSEEUP00000013307   -
[E] Equus caballusHORSE06470  Ensembl ENSECAP00000021677  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).
[E] Monodelphis domesticaMONDO02959  Ensembl ENSMODP00000020138  "2-oxoglutarate dehydrogenase E1 component
[E] Taeniopygia guttataTAEGU03663  Ensembl ENSTGUP00000003463  2-oxoglutarate dehydrogenase E1 component, mitochondrial Precursor (EC 1.2.4.2)(Alpha-ketoglutarate dehydrogenase) [Source:UniProtKB/Swiss-Prot;Acc:Q02218]
[E] Anolis carolinensisANOCA11212  Ensembl ENSACAP00000001761  2-oxoglutarate dehydrogenase E1 component, mitochondrial Precursor (EC 1.2.4.2)(Alpha-ketoglutarate dehydrogenase) [Source:UniProtKB/Swiss-Prot;Acc:Q02218]
[E] Xenopus tropicalisXENTR01927  Ensembl ENSXETP00000041195  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).
[E] Gasterosteus aculeatusGASAC19890  Ensembl ENSGACP00000001427   -
[E] Takifugu rubripesFUGRU20268  Ensembl ENSTRUP00000031098  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase)
[E] Tetraodon nigroviridisTETNG02269  Ensembl ENSTNIP00000008578  2-oxoglutarate dehydrogenase E1 component, mitochondrial Precursor (EC 1.2.4.2)(Alpha-ketoglutarate dehydrogenase) [Source:UniProtKB/Swiss-Prot;Acc:Q02218]
[E] Danio rerioDANRE14300  Ensembl ENSDARP00000009474  Ogdh protein.
[E] Branchiostoma floridaeBRAFL19072  UniProtKB/TrEMBL C3Z4P9  jgi|Brafl1|130310|estExt_fgenesh2_pg.C_4300016
[E] Ciona savignyiCIOSA13539  Ensembl ENSCSAVP00000019169   -
[E] Helobdella robustaHELRO15617   192693  jgi|Helro1|192693
[E] Lottia giganteaLOTGI15377   174449  jgi|Lotgi1|174449|fgenesh2_pg.C_sca_196000020
[E] Anopheles gambiaeANOGA01643  UniProtKB/TrEMBL A7UU86   -
[E] Aedes aegyptiAEDAE00874  UniProtKB/TrEMBL Q175A3   -
[E] Apis melliferaAPIME00509   ENSAPMP00000015095   -
[E] Caenorhabditis briggsaeCAEBR01651  UniProtKB/Swiss-Prot ODO1_CAEBR  
[E] Caenorhabditis elegansCAEEL09912  UniProtKB/Swiss-Prot ODO1_CAEEL  The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740). the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy.
[E] Caenorhabditis japonicaCAEJA17149   WBGene00136839  status:Partially_confirmed
[E] Caenorhabditis remaneiCAERE10090   WBGene00062806  
[E] Ashbya gossypiiASHGO03285  UniProtKB/TrEMBL Q755Z3  Syntenic homolog of Saccharomyces cerevisiae YIL125W (KGD1) AER374Cp
[E] Saccharomyces cerevisiaeYEAST05166  UniProtKB/Swiss-Prot ODO1_YEAST  2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
[E] Laccaria bicolorLACBI02888   e_gww1.3.532.1  jgi|Lacbi1|245492|e_gww1.3.532.1
[E] Ustilago maydisUSTMA04446  UniProtKB/TrEMBL Q4P611  ustilago_maydis hypothetical protein
[E] Arabidopsis thalianaARATH15463   NP_191101.2  2-oxoglutarate dehydrogenase E1 component, putative, oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putative, similar to SP|P20967 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase) {Saccharomyces cerevisiae}; contains Pfam profiles PF02779: Transketolase, pyridine binding domain, PF00676: Dehydrogenase E1 component; go_component: mitochondrion [goid GO:0004591@[IEA,ISS]; GO:0005739@[IDA]; GO:0006096@[IEA]; GO:0030976@[IEA]] [evidence IDA] [pmid 14671022]; go_function: oxoglutarate dehydrogenase (succinyl-transferring) activity [goid GO:0004591] [evidence ISS]; go_function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [goid GO:0016624] [evidence IEA]; go_process: metabolism [goid GO:0008152] [evidence IEA] oxidoreductase, acting on the aldehyde or oxo group of donors, disulfide as acceptor / oxoglutarate dehydrogenase (succinyl-transferring)
[E] Vitis viniferaVITVI15421  UniProtKB/TrEMBL A7PIZ4  
[B] Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)CORU700673  UniProtKB/TrEMBL B1VFU9  2-oxoglutarate dehydrogenase E1 component
[B] Arthrobacter aurescens (strain TC1)ARTAT02512  UniProtKB/TrEMBL A1R7Z1  2-oxoglutarate dehydrogenase, E1 component
[B] Arthrobacter sp. (strain FB24)ARTS202618  UniProtKB/TrEMBL A0JYA4  2-oxoglutarate dehydrogenase, E1 subunit TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit PFAM: dehydrogenase, E1 component; catalytic domain of components of various dehydrogenase complexes; Transketolase, central region KEGG: lxx:Lxx19140 2-oxoglutarate dehydrogenase
[B] Kocuria rhizophila (strain ATCC 9341 / NBRC 12708 / DC2201)KOCRD00941  UniProtKB/TrEMBL B2GLV1  2-oxoglutarate dehydrogenase E1 component
[B] Chlamydophila abortusCHLAB00401  UniProtKB/TrEMBL Q5L672  Highly similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 2-oxoglutarate dehydrogenase e1 component suca or b0726 or c0803 or z0880 or ecs0751 SWALL:ODO1_ECOLI (SWALL:P07015) (933 aa) fasta scores: E(): 4.7e-115, 39.07% id in 934 aa, and to Mycobacterium bovis probable 2-oxoglutarate dehydrogenase suca suca or mb1280C SWALL:CAD94141 (EMBL:BX248338) (1214 aa) fasta scores: E(): 5e-120, 39.95% id in 911 aa 2-oxoglutarate dehydrogenase E1 component