List of all proteins in the group
Allows comparison of IDs and descriptions
of all proteins in the OMA Group.
Display an MSA of all sequences in the group.
The MSA is created using the Mafft program.
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The close groups are made of the set of all
groups that are linked by at least one pair
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Note that not all pairs of proteins coming
from close groups are orthologous. If that
were the case, the two groups would have
been merged.
Display phyletic profile
The "Phyletic profile" displays OMA groups
that have similar patterns of presence/absence
across species. This can be useful to detect
proteins that have complementary function
(e.g. member of the same metabolic pathway).
Compare GO annotations
This function displays a table of all
Gene Ontology (GO) annotations on
proteins of the OMA group. This
allows to compare the annotations
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OMA fingerprint
The fingerprint is a subsequence that is specific to a
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Since the group number is specific to a release, this
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OMA

Keyword Protein Sequence Group Entry

OMA Group 18586

CYTOCHROME P450 51
This group has 63 members: 45 [E]ukaryota 18 [B]acteria
Fingerprint: CAFTLSL

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[E] Homo sapiensHUMAN09066  Ensembl ENSP00000003100   -
[E] Pan troglodytesPANTR10030  Ensembl ENSPTRP00000033177   -
[E] Pongo pygmaeus abeliiPONAB18086  Ensembl ENSPPYP00000019976  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).
[E] Tarsius syrichtaTARSY04328  Ensembl ENSTSYP00000013170  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Microcebus murinusMICMU03815  Ensembl ENSMICP00000002267   -
[E] Otolemur garnettiiOTOGA03710  Ensembl ENSOGAP00000001228   -
[E] Oryctolagus cuniculusRABIT02057  Ensembl ENSOCUP00000003924   -
[E] Ochotona princepsOCHPR14007  Ensembl ENSOPRP00000009477   -
[E] Cavia porcellusCAVPO05775  Ensembl ENSCPOP00000013149  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Dipodomys ordiiDIPOR08719  Ensembl ENSDORP00000009078  
[E] Mus musculusMOUSE22479  UniProtKB/Swiss-Prot CP51A_MOUSE  cytochrome P450, family 51
[E] Rattus norvegicusRATNO00183  UniProtKB/Swiss-Prot CP51A_RAT  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM). [Source:UniProtKB/Swiss- Prot;Acc:Q64654]
[E] Procavia capensisPROCA10216  Ensembl ENSPCAP00000011782  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Loxodonta africanaLOXAF07552  Ensembl ENSLAFP00000000055   -
[E] Echinops telfairiECHTE04616  Ensembl ENSETEP00000000531   -
[E] Canis familiarisCANFA09602  Ensembl ENSCAFP00000002855   -
[E] Tursiops truncatusTURTR05653  Ensembl ENSTTRP00000009795   -
[E] Bos taurusBOVIN03205  Ensembl ENSBTAP00000002582  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM)
[E] Lama guanicoe pacosLAMPA05148  Ensembl ENSVPAP00000004832  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Pteropus vampyrusPTEVA00311  Ensembl ENSPVAP00000006252   -
[E] Myotis lucifugusMYOLU10491  Ensembl ENSMLUP00000016158   -
[E] Sorex araneusSORAR09049  Ensembl ENSSARP00000000411   -
[E] Equus caballusHORSE07796  Ensembl ENSECAP00000005096  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).
[E] Dasypus novemcinctusDASNO02476  Ensembl ENSDNOP00000006420   -
[E] Monodelphis domesticaMONDO20122  Ensembl ENSMODP00000013290  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).
[E] Gallus gallusCHICK08429  Ensembl ENSGALP00000015237   -
[E] Taeniopygia guttataTAEGU05834  Ensembl ENSTGUP00000001502  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Anolis carolinensisANOCA15641  Ensembl ENSACAP00000015429  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Xenopus tropicalisXENTR05464  Ensembl ENSXETP00000007437   -
[E] Oryzias latipesORYLA19671  Ensembl ENSORLP00000024830   -
[E] Gasterosteus aculeatusGASAC09701  Ensembl ENSGACP00000005472   -
[E] Takifugu rubripesFUGRU20577  Ensembl ENSTRUP00000033886  Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM)
[E] Tetraodon nigroviridisTETNG15643  Ensembl ENSTNIP00000020679  Cytochrome P450 51A1 (EC 1.14.13.70)(CYPLI)(P450LI)(Sterol 14-alpha demethylase)(Lanosterol 14-alpha demethylase)(LDM)(P450- 14DM)(P45014DM) [Source:UniProtKB/Swiss-Prot;Acc:Q16850]
[E] Danio rerioDANRE22296  UniProtKB/TrEMBL Q1JPY5  cytochrome P450, family 51
[E] Branchiostoma floridaeBRAFL14520  UniProtKB/TrEMBL C3YBZ8  jgi|Brafl1|115377|estExt_fgenesh2_pm.C_2170007
[E] Helobdella robustaHELRO12819   157030  jgi|Helro1|157030
[E] Lottia giganteaLOTGI02930   108695  jgi|Lotgi1|108695|e_gw1.9.115.1
[E] Dictyostelium discoideumDICDI05560  UniProtKB/Swiss-Prot CP51_DICDI  
[E] Leishmania braziliensisLEIBR07144  UniProtKB/TrEMBL A4H6N4  lanosterol 14-alpha-demethylase, putative
[E] Ostreococcus lucimarinusOSTLU05336  UniProtKB/TrEMBL A4S4N2  predicted protein go_process: electron transport
[E] Oryza sativaORYSA24348   BAF28354.1  Cytochrome P450 51 (EC 1.14.13.70) (CYPLI) (P450-LIA1) (Obtusifoliol 14-alpha demethylase) (Fragment) contains InterPro domain(s): IPR001128, IPR002403 has GO asignment(s): GO:0004497, GO:0006118 similar to P93596 supported by AK121491
[E] Sorghum bicolorSORBI23274  UniProtKB/TrEMBL Q84YE6  jgi|Sorbi1|5008392|estExt_fgenesh1_pg.C_chr_80244
[E] Populus trichocarpaPOPTR31172  UniProtKB/TrEMBL B9GMU7  jgi|Poptr1_1|750989|fgenesh4_pg.C_LG_I000592
[E] Arabidopsis thalianaARATH01079  UniProtKB/TrEMBL Q9SAA9  obtusifoliol 14-demethylase (CYP51), identical to obtusifoliol 14-demethylase (GI:14624983) (Arabidopsis thaliana); go_component: endomembrane system [goid GO:0012505] [evidence IEA]; go_function: monooxygenase activity [goid GO:0004497] [evidence IEA]; go_function: iron ion binding [goid GO:0005506] [evidence IEA]; go_function: oxygen binding [goid GO:0019825] [evidence ISS]; go_function: heme binding [goid GO:0020037] [evidence IEA]; go_process: sterol biosynthesis [goid GO:0016126] [evidence TAS] [pmid 11437378] CYP51G1 (CYTOCHROME P450 51); heme binding / iron ion binding / monooxygenase/ oxygen binding
[E] Vitis viniferaVITVI15558  UniProtKB/TrEMBL A7QLM7  
[B] Mycobacterium avium (strain 104)MYCA100675  UniProtKB/TrEMBL A0QAP6  cytochrome P450 51 identified by match to protein family HMM PF00067
[B] Mycobacterium paratuberculosisMYCPA00592  UniProtKB/TrEMBL Q743I7  hypothetical protein
[B] Mycobacterium gilvum (strain PYR-GCK)MYCGI01525  UniProtKB/TrEMBL A4T7M2  cytochrome P450 PFAM: cytochrome P450 KEGG: mva:Mvan_5161 cytochrome P450
[B] Mycobacterium marinum (strain ATCC BAA-535 / M)MYCMM04831  UniProtKB/TrEMBL B2HH81  Cytochrome P450 51B1 Cyp51B1
[B] Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)MYCS205552  UniProtKB/TrEMBL A0R4K2  Cytochrome P450 51
[B] Mycobacterium sp. (strain JLS)MYCSJ04873  UniProtKB/TrEMBL A3Q6F3  cytochrome P450 PFAM: cytochrome P450 KEGG: mmc:Mmcs_4582 cytochrome P450
[B] Mycobacterium sp. (strain KMS)MYCSK04575  UniProtKB/TrEMBL A1UM03  cytochrome P450 PFAM: cytochrome P450 KEGG: mmc:Mmcs_4582 cytochrome P450
[B] Mycobacterium sp. (strain MCS)MYCSS04542  UniProtKB/TrEMBL Q1B348  Cytochrome P450
[B] Mycobacterium bovisMYCBO00786  UniProtKB/Swiss-Prot CP51_MYCBO  Mb0787c, cyp51, len: 451 aa. Equivalent to Rv0764c, len: 451 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 451 aa overlap). cyp51, cytochrome P450 51 (sterol 14-alpha demethylase) (EC 1.14.14.-), similar to others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in 439 aa overlap); NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM)
[B] Mycobacterium bovis (strain BCG / Paris 1173P2)MYCBP00789  UniProtKB/TrEMBL A1KGP7  Cytochrome P450 51 cyp51
[B] Mycobacterium tuberculosisMYCTU02000  UniProtKB/Swiss-Prot CP51_MYCTU  Cytochrome P450 51
[B] Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)MYCTA00781  UniProtKB/TrEMBL A5U0F2  Cytochrome p450 51 cyp51
[B] Mycobacterium tuberculosis (strain F11)MYCTF00760  UniProtKB/TrEMBL A5WKD3  cytochrome P450 51 cyp51 Mapped to H37Rv Rv0764c
[B] Mycobacterium ulcerans (strain Agy99)MYCUA00392  UniProtKB/TrEMBL A0PLF7  cytochrome P450 51B1 Cyp51B1 cytoplasmic protein involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol.
[B] Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)MYCVP05004  UniProtKB/Swiss-Prot CP51_MYCVP  cytochrome P450 PFAM: cytochrome P450 KEGG: mmc:Mmcs_4582 cytochrome P450
[B] Rhodococcus erythropolis (strain PR4 / NBRC 100887)RHOE403369  UniProtKB/TrEMBL C1A0F0  Cytochrome P450 51
[B] Rhodococcus opacus (strain B4)RHOOB04767  UniProtKB/TrEMBL C1BBG4  Cytochrome P450 51
[B] Rhodococcus sp. (strain RHA1)RHOSR04592  UniProtKB/TrEMBL Q0S7M9  Cytochrome P450 CYP51