List of all proteins in the group
Allows comparison of IDs and descriptions
of all proteins in the OMA Group.
Display an MSA of all sequences in the group.
The MSA is created using the Mafft program.
The jalview applet allows for numerous
display and export options.
Display closely related groups
The close groups are made of the set of all
groups that are linked by at least one pair
of orthologs.
Note that not all pairs of proteins coming
from close groups are orthologous. If that
were the case, the two groups would have
been merged.
Display phyletic profile
The "Phyletic profile" displays OMA groups
that have similar patterns of presence/absence
across species. This can be useful to detect
proteins that have complementary function
(e.g. member of the same metabolic pathway).
Compare GO annotations
This function displays a table of all
Gene Ontology (GO) annotations on
proteins of the OMA group. This
allows to compare the annotations
and serves as an additional description
of this OMA group.
OMA fingerprint
The fingerprint is a subsequence that is specific to a
certain group in the current OMA release
Since the group number is specific to a release, this
is the best way to track a group across releases.
OMA

Keyword Protein Sequence Group Entry

OMA Group 189836

Dihydrofolate reductase
This group has 110 members: 1 [A]rchaea 109 [B]acteria
Fingerprint: GLPWHLP

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[A] Haloarcula marismortuiHALMA03455  UniProtKB/Swiss-Prot DYR2_HALMA  dihydrofolate reductase
[B] Azobacteroides pseudotrichonymphae genomovar. CFP2AZOPC00507  UniProtKB/TrEMBL B6YRF0  Dihydrofolate reductase
[B] Salinibacter ruber (strain DSM 13855)SALRD00396  UniProtKB/TrEMBL Q2S5H3  dihydrofolate reductase identified by match to protein family HMM PF00186
[B] Bacillus clausii (strain KSM-K16)BACSK02941  UniProtKB/TrEMBL Q5WDS2  dihydrofolate reductase
[B] Oceanobacillus iheyensisOCEIH01735  UniProtKB/TrEMBL Q8EQG1  CDS_ID OB1739 dihydrofolate reductase
[B] Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)EXIS201697  UniProtKB/TrEMBL B1YHM1  Dihydrofolate reductase
[B] Listeria innocuaLISIN01965  UniProtKB/TrEMBL Q92AD5  similar to dihydrofolate reductases
[B] Staphylococcus aureus (strain COL)STAAC01424  UniProtKB/Swiss-Prot DYR_STAAC  identified by similarity to SP:P10167; match to protein family HMM PF00186 dihydrofolate reductase
[B] Staphylococcus aureus (strain JH1)STAA201475  UniProtKB/TrEMBL A6U1P6  Dihydrofolate reductase PFAM: dihydrofolate reductase region KEGG: sao:SAOUHSC_01434 dihydrofolate reductase
[B] Staphylococcus aureus (strain JH9)STAA901446  UniProtKB/TrEMBL A5ISV7  dihydrofolate reductase PFAM: dihydrofolate reductase region
[B] Staphylococcus aureus (strain MRSA252)STAAR01393  UniProtKB/Swiss-Prot DYR_STAAR  Previously sequenced as Staphylococcus aureus trimethoprim-sensitive dihydrofolate reductase type I DfrB SW:DYRB_STAAU (P10167) (158 aa) fasta scores: E(): 3.1e-62, 100.000% id in 158 aa. Similar to Staphylococcus epidermidis dihydrofolate reductase DfrC SW:DYR_STAEP (Q59908) (161 aa) fasta scores: E(): 4.1e-52, 81.761% id in 159 aa dihydrofolate reductase type I
[B] Staphylococcus aureus (strain MSSA476)STAAS01373  UniProtKB/Swiss-Prot DYR_STAAS  Ortholog of S. aureus MRSA252 (BX571856) SAR1439 dihydrofolate reductase type I
[B] Staphylococcus aureus (strain MW2)STAAW01315  UniProtKB/Swiss-Prot DYR_STAAW  dihydrofolate reductase
[B] Staphylococcus aureus (strain Mu3 / ATCC 700698)STAA101399  UniProtKB/TrEMBL A7X2B2  Dihydrofolate reductase
[B] Staphylococcus aureus (strain Mu50 / ATCC 700699)STAAM01420  UniProtKB/Swiss-Prot DYR_STAAM  dihydrofolate reductase
[B] Staphylococcus aureus (strain N315)STAAN01291  UniProtKB/Swiss-Prot DYR_STAAN  dihydrofolate reductase
[B] Staphylococcus aureus (strain NCTC 8325)STAA801350  UniProtKB/TrEMBL Q2FYK6  dihydrofolate reductase
[B] Staphylococcus aureus (strain Newman)STAAE01295  UniProtKB/TrEMBL A6QGX7  Dihydrofolate reductase
[B] Staphylococcus aureus (strain USA300 / TCH1516)STAAT01327  UniProtKB/TrEMBL A8Z405  dihydrofolate reductase
[B] Staphylococcus aureus (strain USA300)STAA301292  UniProtKB/TrEMBL C5N5I8  dihydrofolate reductase identified by match to protein family HMM PF00186
[B] Staphylococcus aureus (strain bovine RF122)STAAB01273  UniProtKB/TrEMBL Q2YY41  trimethoprim-sensitive dihydrofolate reductase
[B] Staphylococcus epidermidis (strain ATCC 12228)STAES01098  UniProtKB/Swiss-Prot DYR_STAES  Dihydrofolate reductase
[B] Staphylococcus epidermidis (strain ATCC 35984 / RP62A)STAEQ00970  UniProtKB/Swiss-Prot DYR_STAEQ  identified by similarity to EGAD:43004; match to protein family HMM PF00186 dihydrofolate reductase
[B] Staphylococcus haemolyticus (strain JCSC1435)STAHJ01441  UniProtKB/TrEMBL Q4L6D6  dihydrofolate reductase
[B] Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)STAS101312  UniProtKB/TrEMBL Q49XN7  similar to gi|57284568|gb|AAW36662.1| [Staphylococcus aureus subsp. aureus COL], percent identity 84 in 158 aa, BLASTP E(): 4e-74 dihydrofolate reductase
[B] Clostridium acetobutylicumCLOAB02956  UniProtKB/TrEMBL Q97EV2  Dihydrofolate reductase
[B] Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)CLOK502069  UniProtKB/TrEMBL A5MZB6  DfrD
[B] Lactobacillus acidophilusLACAC00850  UniProtKB/TrEMBL C2HNZ8  COG0262 Dihydrofolate reductase dihydrofolate reductase
[B] Lactobacillus brevis (strain ATCC 367 / JCM 1170)LACBA00742  UniProtKB/TrEMBL Q03S94  Dihydrofolate reductase
[B] Lactobacillus casei (strain ATCC 334)LACC301254  UniProtKB/TrEMBL Q039F6  Dihydrofolate reductase
[B] Lactobacillus casei (strain BL23)LACCB01523  UniProtKB/TrEMBL B3WE88  Dihydrofolate reductase
[B] Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)LACDA00768  UniProtKB/TrEMBL Q1GAP1  Dihydrofolate reductase
[B] Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)LACDB00646  UniProtKB/TrEMBL Q04B28  Dihydrofolate reductase
[B] Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)LACGA00745  UniProtKB/TrEMBL Q044A0  Dihydrofolate reductase
[B] Lactobacillus helveticus (strain DPC 4571)LACH400738  UniProtKB/TrEMBL A8YUW1  Dihydrofolate reductase
[B] Lactobacillus reuteri (strain DSM 20016)LACRD00744  UniProtKB/TrEMBL A5VJL0  Dihydrofolate reductase
[B] Lactobacillus reuteri (strain JCM 1112)LACRJ00726  UniProtKB/TrEMBL B2G724  dihydrofolate reductase
[B] Lactobacillus sakei subsp. sakei (strain 23K)LACSS00987  UniProtKB/TrEMBL Q38WX9  Dihydrofolate reductase
[B] Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)PEDPA01014  UniProtKB/TrEMBL Q03F97  Dihydrofolate reductase
[B] Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)LEUMM00694  UniProtKB/TrEMBL Q03Y56  Dihydrofolate reductase
[B] Oenococcus oeni (strain BAA-331 / PSU-1)OENOB00908  UniProtKB/TrEMBL Q04F50  Dihydrofolate reductase
[B] Lactococcus lactis subsp. cremoris (strain MG1363)LACLM01277  UniProtKB/TrEMBL A2RKW6  DfrA protein
[B] Lactococcus lactis subsp. cremoris (strain SK11)LACLS01118  UniProtKB/TrEMBL Q02Z24  Dihydrofolate reductase
[B] Lactococcus lactis subsp. lactisLACLA01122  UniProtKB/Swiss-Prot DYR_LACLA  Dihydrofolate reductase
[B] Streptococcus agalactiae (serotype III)STRA301285  UniProtKB/TrEMBL Q8E4L7  similar to dihydrofolate reductase unknown
[B] Streptococcus agalactiae (serotype V)STRA501266  UniProtKB/TrEMBL Q8DZ08  identified by match to PFAM protein family HMM PF00186 dihydrofolate reductase
[B] Streptococcus agalactiae serotype IaSTRA101213  UniProtKB/TrEMBL Q3K0J8  identified by similarity to SP:Q54801; match to protein family HMM PF00186 dihydrofolate reductase
[B] Streptococcus equi subsp. equi (strain 4047)STRE401005  UniProtKB/TrEMBL C0M9R5  dihydrofolate reductase
[B] Streptococcus equi subsp. zooepidemicus (strain H70)STRS700881  UniProtKB/TrEMBL C0MEW3  dihydrofolate reductase Ortholog of S. equi 4047 (FM204883) SEQ1111
[B] Streptococcus equi subsp. zooepidemicus (strain MGCS10565)STREM01026  UniProtKB/TrEMBL B4U362  Dihydrofolate reductase DhfR
[B] Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)STRGC01108  UniProtKB/TrEMBL A8AXC0  Dihydrofolate reductase
[B] Streptococcus mutansSTRMU00853  UniProtKB/TrEMBL Q8DUI2  Best Blastp Hit: gb|AAC33872.1| (AF055727) dihydrofolate reductase [Streptococcus pneumoniae] putative dihydrofolate reductase
[B] Streptococcus pneumoniaeSTRPN01448  UniProtKB/Swiss-Prot DYR_STRPN  dihydrofolate reductase
[B] Streptococcus pneumoniae (strain ATCC BAA-255 / R6)STRR601421  UniProtKB/TrEMBL Q7CRB0  Dihydrofolate reductase
[B] Streptococcus pneumoniae (strain CGSP14)STRPS01540  UniProtKB/TrEMBL B2IR89  Dihydrofolate reductase
[B] Streptococcus pneumoniae (strain Hungary19A-6)STRPI01538  UniProtKB/TrEMBL B1ICZ1  Dihydrofolate reductase
[B] Streptococcus pneumoniae (strain JJA)STRZJ01396  UniProtKB/TrEMBL C1CFF4  Dihydrofolate reductase
[B] Streptococcus pneumoniae (strain P1031)STRZP01455  UniProtKB/TrEMBL C1CLS0  Dihydrofolate reductase
[B] Streptococcus pneumoniae serotype 19F (strain G54)STRP401469  UniProtKB/TrEMBL B5E6L4  Dihydrofolate reductase
[B] Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)STRP201325  UniProtKB/TrEMBL Q04JH7  dihydrofolate reductase equivalent gene in S.pneumoniae TIGR4 = SP1571; equivalent gene in S.pneumoniae R6 = spr1429; identified by match to protein family HMM PF00186
[B] Streptococcus pyogenes (serotype M3)STRP300601  UniProtKB/TrEMBL Q8K7V9  best blastp hit: gb|AAK33803.1| (AE006538) putative dihydrofolate reductase [Streptococcus pyogenes M1 GAS] putative dihydrofolate reductase
[B] Streptococcus pyogenes serotype M1STRP101203  UniProtKB/TrEMBL Q9A091  Putative dihydrofolate reductase
[B] Streptococcus pyogenes serotype M12 (strain MGAS2096)STRPB00749  UniProtKB/TrEMBL Q1JC95  Dihydrofolate reductase
[B] Streptococcus pyogenes serotype M12 (strain MGAS9429)STRPC00737  UniProtKB/TrEMBL Q1JM79  dihydrofolate reductase
[B] Streptococcus pyogenes serotype M2 (strain MGAS10270)STRPD00730  UniProtKB/TrEMBL Q1JHC4  Dihydrofolate reductase
[B] Streptococcus pyogenes serotype M28STRPM00663  UniProtKB/TrEMBL Q48U24  dihydrofolate reductase
[B] Streptococcus pyogenes serotype M4 (strain MGAS10750)STRPF00769  UniProtKB/TrEMBL Q1J743  Dihydrofolate reductase
[B] Streptococcus pyogenes serotype M49 (strain NZ131)STRPZ00652  UniProtKB/TrEMBL B5XL01  Dihydrofolate reductase
[B] Streptococcus sanguinis (strain SK36)STRSV01033  UniProtKB/TrEMBL A3CMV0  Dihydrofolate reductase, putative
[B] Streptococcus suis (strain 05ZYH33)STRSY00824  UniProtKB/TrEMBL A4VUL2  Dihydrofolate reductase
[B] Streptococcus suis (strain 98HAH33)STRS200824  UniProtKB/TrEMBL A4W0V4  Dihydrofolate reductase
[B] Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)STRT200552  UniProtKB/TrEMBL Q5M5B2  dihydrofolate reductase
[B] Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)STRTD00487  UniProtKB/TrEMBL Q03LN2  Dihydrofolate reductase
[B] Streptococcus thermophilus (strain CNRZ 1066)STRT100552  UniProtKB/TrEMBL Q5M0S6  dihydrofolate reductase
[B] Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906)METSB00589  UniProtKB/TrEMBL B8EN62  Dihydrofolate reductase
[B] Bradyrhizobium japonicumBRAJA06452  UniProtKB/TrEMBL Q89G37  Dihydrofolate reductase
[B] Methylobacterium chloromethanicum (strain CM4 / NCIMB 13688)METC402741  UniProtKB/TrEMBL B7KQG1  Dihydrofolate reductase PFAM: dihydrofolate reductase region; KEGG: mex:Mext_2659 dihydrofolate reductase
[B] Methylobacterium extorquens (strain PA1)METEP02615  UniProtKB/TrEMBL A9W645  Dihydrofolate reductase
[B] Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)METPB02727  UniProtKB/TrEMBL B1ZDL8  Dihydrofolate reductase
[B] Erythrobacter litoralis (strain HTCC2594)ERYLH02702  UniProtKB/TrEMBL Q2N685  dihydrofolate reductase COG0262 Dihydrofolate reductase
[B] Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)SPHWW03738  UniProtKB/TrEMBL A5VCW5  Dihydrofolate reductase
[B] Zymomonas mobilisZYMMO00319  UniProtKB/TrEMBL Q5NQQ9  COG0262 dihydrofolate reductase
[B] Alteromonas macleodii (strain DSM 17117 / Deep ecotype)ALTMD03676  UniProtKB/TrEMBL B4RZH2  Dihydrofolate reductase type I, trimethoprim resistance
[B] Pseudoalteromonas haloplanktis (strain TAC 125)PSEHT02582  UniProtKB/TrEMBL Q3IFF7  Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8423162, 10408091; Product type e : enzyme dihydrofolate reductase type I, trimethoprim resistance
[B] Shewanella halifaxensis (strain HAW-EB4)SHEHH00908  UniProtKB/TrEMBL B0TUI5  Dihydrofolate reductase
[B] Shewanella piezotolerans (strain WP3 / JCM 13877)SHEPW03878  UniProtKB/TrEMBL B8CSY0  Dihydrofolate reductase
[B] Dichelobacter nodosus (strain VCS1703A)DICNV00744  UniProtKB/TrEMBL A5EUV9  Dihydrofolate reductase
[B] Enterobacter sp. (strain 638)ENT3800593  UniProtKB/TrEMBL A4W6F4  Dihydrofolate reductase
[B] Klebsiella pneumoniae (strain 342)KLEP304578  UniProtKB/TrEMBL B5Y1Z7  Dihydrofolate reductase
[B] Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)KLEP700044  UniProtKB/TrEMBL A6T4I4  Dihydrofolate reductase type I, trimethoprim resistance
[B] Serratia proteamaculans (strain 568)SERP500711  UniProtKB/TrEMBL A8G9N6  Dihydrofolate reductase
[B] Legionella pneumophila (strain Corby)LEGPC00374  UniProtKB/TrEMBL A5IAH4  Dihydrofolate reductase
[B] Legionella pneumophila (strain Lens)LEGPL00350  UniProtKB/TrEMBL Q5WZM8  dihydrofolate reductase FolA
[B] Legionella pneumophila (strain Paris)LEGPA00376  UniProtKB/TrEMBL Q5X875  dihydrofolate reductase FolA
[B] Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152)LEGPH00293  UniProtKB/TrEMBL Q5ZYR2  conserved gene dihydrofolate reductase
[B] Actinobacillus pleuropneumoniae serotype 3 (strain JL03)ACTPJ00844  UniProtKB/TrEMBL B0BPG8  Dihydrofolate reductase
[B] Actinobacillus pleuropneumoniae serotype 5b (strain L20)ACTP200868  UniProtKB/TrEMBL A3N0P3  Dihydrofolate reductase
[B] Actinobacillus pleuropneumoniae serotype 7 (strain AP76)ACTP700924  UniProtKB/TrEMBL B3GXM9  Dihydrofolate reductase
[B] Haemophilus ducreyiHAEDU00957  UniProtKB/TrEMBL Q7VM78  dihydrofolate reductase
[B] Haemophilus parasuis serovar 5 (strain SH0165)HAEPS00613  UniProtKB/TrEMBL B8F4S8  Dihydrofolate reductase
[B] Thiomicrospira crunogena (strain XCL-2)THICR00571  UniProtKB/TrEMBL Q31I54  Dihydrofolate reductase
[B] Xanthomonas campestris pv. campestris (strain B100)XANCB03545  UniProtKB/TrEMBL B0RUI6  Dihydrofolate reductase , probable
[B] Xanthomonas campestris pv. vesicatoria (strain 85-10)XANC500879  UniProtKB/TrEMBL Q3BX85  dihydrofolate reductase
[B] Xanthomonas oryzae (pv. oryzae)XANOR03357  UniProtKB/TrEMBL Q5GWB6  identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark dihydrofolate reductase type III
[B] Xanthomonas oryzae pv. oryzae (strain MAFF 311018)XANOM03254  UniProtKB/TrEMBL Q2NZI1  dihydrofolate reductase type III identified by sequence similarity; putative; ORF located using Blastx/Glimmer/GeneHacker
[B] Xanthomonas oryzae pv. oryzae (strain PXO99A)XANOP01038  UniProtKB/TrEMBL B2SPT0  Dihydrofolate reductase
[B] Xylella fastidiosaXYLFA02283  UniProtKB/TrEMBL Q9PB14  similar to SP|P12833 (percent identity: 43 %/query alignment coverage: 87.2 %/subject alignment coverage: 101.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -66 dihydrofolate reductase type III
[B] Xylella fastidiosa (strain M12)XYLFM01315  UniProtKB/TrEMBL B0U3I9  Dihydrofolate reductase
[B] Xylella fastidiosa (strain M23)XYLF201359  UniProtKB/TrEMBL B2I6E9  Dihydrofolate reductase
[B] Xylella fastidiosa (strain Temecula1 / ATCC 700964)XYLFT01271  UniProtKB/TrEMBL Q87BT5  Dihydrofolate reductase type III