| [A] Haloarcula marismortui | HALMA03455 | DYR2_HALMA | dihydrofolate reductase |
| [B] Azobacteroides pseudotrichonymphae genomovar. CFP2 | AZOPC00507 | B6YRF0 | Dihydrofolate reductase |
| [B] Salinibacter ruber (strain DSM 13855) | SALRD00396 | Q2S5H3 | dihydrofolate reductase identified by match to protein family HMM PF00186 |
| [B] Bacillus clausii (strain KSM-K16) | BACSK02941 | Q5WDS2 | dihydrofolate reductase |
| [B] Oceanobacillus iheyensis | OCEIH01735 | Q8EQG1 | CDS_ID OB1739 dihydrofolate reductase |
| [B] Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) | EXIS201697 | B1YHM1 | Dihydrofolate reductase |
| [B] Listeria innocua | LISIN01965 | Q92AD5 | similar to dihydrofolate reductases |
| [B] Staphylococcus aureus (strain COL) | STAAC01424 | DYR_STAAC | identified by similarity to SP:P10167; match to protein family HMM PF00186 dihydrofolate reductase |
| [B] Staphylococcus aureus (strain JH1) | STAA201475 | A6U1P6 | Dihydrofolate reductase PFAM: dihydrofolate reductase region KEGG: sao:SAOUHSC_01434 dihydrofolate reductase |
| [B] Staphylococcus aureus (strain JH9) | STAA901446 | A5ISV7 | dihydrofolate reductase PFAM: dihydrofolate reductase region |
| [B] Staphylococcus aureus (strain MRSA252) | STAAR01393 | DYR_STAAR | Previously sequenced as Staphylococcus aureus trimethoprim-sensitive dihydrofolate reductase type I DfrB SW:DYRB_STAAU (P10167) (158 aa) fasta scores: E(): 3.1e-62, 100.000% id in 158 aa. Similar to Staphylococcus epidermidis dihydrofolate reductase DfrC SW:DYR_STAEP (Q59908) (161 aa) fasta scores: E(): 4.1e-52, 81.761% id in 159 aa dihydrofolate reductase type I |
| [B] Staphylococcus aureus (strain MSSA476) | STAAS01373 | DYR_STAAS | Ortholog of S. aureus MRSA252 (BX571856) SAR1439 dihydrofolate reductase type I |
| [B] Staphylococcus aureus (strain MW2) | STAAW01315 | DYR_STAAW | dihydrofolate reductase |
| [B] Staphylococcus aureus (strain Mu3 / ATCC 700698) | STAA101399 | A7X2B2 | Dihydrofolate reductase |
| [B] Staphylococcus aureus (strain Mu50 / ATCC 700699) | STAAM01420 | DYR_STAAM | dihydrofolate reductase |
| [B] Staphylococcus aureus (strain N315) | STAAN01291 | DYR_STAAN | dihydrofolate reductase |
| [B] Staphylococcus aureus (strain NCTC 8325) | STAA801350 | Q2FYK6 | dihydrofolate reductase |
| [B] Staphylococcus aureus (strain Newman) | STAAE01295 | A6QGX7 | Dihydrofolate reductase |
| [B] Staphylococcus aureus (strain USA300 / TCH1516) | STAAT01327 | A8Z405 | dihydrofolate reductase |
| [B] Staphylococcus aureus (strain USA300) | STAA301292 | C5N5I8 | dihydrofolate reductase identified by match to protein family HMM PF00186 |
| [B] Staphylococcus aureus (strain bovine RF122) | STAAB01273 | Q2YY41 | trimethoprim-sensitive dihydrofolate reductase |
| [B] Staphylococcus epidermidis (strain ATCC 12228) | STAES01098 | DYR_STAES | Dihydrofolate reductase |
| [B] Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | STAEQ00970 | DYR_STAEQ | identified by similarity to EGAD:43004; match to protein family HMM PF00186 dihydrofolate reductase |
| [B] Staphylococcus haemolyticus (strain JCSC1435) | STAHJ01441 | Q4L6D6 | dihydrofolate reductase |
| [B] Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) | STAS101312 | Q49XN7 | similar to gi|57284568|gb|AAW36662.1| [Staphylococcus aureus subsp. aureus COL], percent identity 84 in 158 aa, BLASTP E(): 4e-74 dihydrofolate reductase |
| [B] Clostridium acetobutylicum | CLOAB02956 | Q97EV2 | Dihydrofolate reductase |
| [B] Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) | CLOK502069 | A5MZB6 | DfrD |
| [B] Lactobacillus acidophilus | LACAC00850 | C2HNZ8 | COG0262 Dihydrofolate reductase dihydrofolate reductase |
| [B] Lactobacillus brevis (strain ATCC 367 / JCM 1170) | LACBA00742 | Q03S94 | Dihydrofolate reductase |
| [B] Lactobacillus casei (strain ATCC 334) | LACC301254 | Q039F6 | Dihydrofolate reductase |
| [B] Lactobacillus casei (strain BL23) | LACCB01523 | B3WE88 | Dihydrofolate reductase |
| [B] Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081) | LACDA00768 | Q1GAP1 | Dihydrofolate reductase |
| [B] Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) | LACDB00646 | Q04B28 | Dihydrofolate reductase |
| [B] Lactobacillus gasseri (strain ATCC 33323 / DSM 20243) | LACGA00745 | Q044A0 | Dihydrofolate reductase |
| [B] Lactobacillus helveticus (strain DPC 4571) | LACH400738 | A8YUW1 | Dihydrofolate reductase |
| [B] Lactobacillus reuteri (strain DSM 20016) | LACRD00744 | A5VJL0 | Dihydrofolate reductase |
| [B] Lactobacillus reuteri (strain JCM 1112) | LACRJ00726 | B2G724 | dihydrofolate reductase |
| [B] Lactobacillus sakei subsp. sakei (strain 23K) | LACSS00987 | Q38WX9 | Dihydrofolate reductase |
| [B] Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) | PEDPA01014 | Q03F97 | Dihydrofolate reductase |
| [B] Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523) | LEUMM00694 | Q03Y56 | Dihydrofolate reductase |
| [B] Oenococcus oeni (strain BAA-331 / PSU-1) | OENOB00908 | Q04F50 | Dihydrofolate reductase |
| [B] Lactococcus lactis subsp. cremoris (strain MG1363) | LACLM01277 | A2RKW6 | DfrA protein |
| [B] Lactococcus lactis subsp. cremoris (strain SK11) | LACLS01118 | Q02Z24 | Dihydrofolate reductase |
| [B] Lactococcus lactis subsp. lactis | LACLA01122 | DYR_LACLA | Dihydrofolate reductase |
| [B] Streptococcus agalactiae (serotype III) | STRA301285 | Q8E4L7 | similar to dihydrofolate reductase unknown |
| [B] Streptococcus agalactiae (serotype V) | STRA501266 | Q8DZ08 | identified by match to PFAM protein family HMM PF00186 dihydrofolate reductase |
| [B] Streptococcus agalactiae serotype Ia | STRA101213 | Q3K0J8 | identified by similarity to SP:Q54801; match to protein family HMM PF00186 dihydrofolate reductase |
| [B] Streptococcus equi subsp. equi (strain 4047) | STRE401005 | C0M9R5 | dihydrofolate reductase |
| [B] Streptococcus equi subsp. zooepidemicus (strain H70) | STRS700881 | C0MEW3 | dihydrofolate reductase Ortholog of S. equi 4047 (FM204883) SEQ1111 |
| [B] Streptococcus equi subsp. zooepidemicus (strain MGCS10565) | STREM01026 | B4U362 | Dihydrofolate reductase DhfR |
| [B] Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) | STRGC01108 | A8AXC0 | Dihydrofolate reductase |
| [B] Streptococcus mutans | STRMU00853 | Q8DUI2 | Best Blastp Hit: gb|AAC33872.1| (AF055727) dihydrofolate reductase [Streptococcus pneumoniae] putative dihydrofolate reductase |
| [B] Streptococcus pneumoniae | STRPN01448 | DYR_STRPN | dihydrofolate reductase |
| [B] Streptococcus pneumoniae (strain ATCC BAA-255 / R6) | STRR601421 | Q7CRB0 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae (strain CGSP14) | STRPS01540 | B2IR89 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae (strain Hungary19A-6) | STRPI01538 | B1ICZ1 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae (strain JJA) | STRZJ01396 | C1CFF4 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae (strain P1031) | STRZP01455 | C1CLS0 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae serotype 19F (strain G54) | STRP401469 | B5E6L4 | Dihydrofolate reductase |
| [B] Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | STRP201325 | Q04JH7 | dihydrofolate reductase equivalent gene in S.pneumoniae TIGR4 = SP1571; equivalent gene in S.pneumoniae R6 = spr1429; identified by match to protein family HMM PF00186 |
| [B] Streptococcus pyogenes (serotype M3) | STRP300601 | Q8K7V9 | best blastp hit: gb|AAK33803.1| (AE006538) putative dihydrofolate reductase [Streptococcus pyogenes M1 GAS] putative dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M1 | STRP101203 | Q9A091 | Putative dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M12 (strain MGAS2096) | STRPB00749 | Q1JC95 | Dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M12 (strain MGAS9429) | STRPC00737 | Q1JM79 | dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M2 (strain MGAS10270) | STRPD00730 | Q1JHC4 | Dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M28 | STRPM00663 | Q48U24 | dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M4 (strain MGAS10750) | STRPF00769 | Q1J743 | Dihydrofolate reductase |
| [B] Streptococcus pyogenes serotype M49 (strain NZ131) | STRPZ00652 | B5XL01 | Dihydrofolate reductase |
| [B] Streptococcus sanguinis (strain SK36) | STRSV01033 | A3CMV0 | Dihydrofolate reductase, putative |
| [B] Streptococcus suis (strain 05ZYH33) | STRSY00824 | A4VUL2 | Dihydrofolate reductase |
| [B] Streptococcus suis (strain 98HAH33) | STRS200824 | A4W0V4 | Dihydrofolate reductase |
| [B] Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) | STRT200552 | Q5M5B2 | dihydrofolate reductase |
| [B] Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) | STRTD00487 | Q03LN2 | Dihydrofolate reductase |
| [B] Streptococcus thermophilus (strain CNRZ 1066) | STRT100552 | Q5M0S6 | dihydrofolate reductase |
| [B] Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) | METSB00589 | B8EN62 | Dihydrofolate reductase |
| [B] Bradyrhizobium japonicum | BRAJA06452 | Q89G37 | Dihydrofolate reductase |
| [B] Methylobacterium chloromethanicum (strain CM4 / NCIMB 13688) | METC402741 | B7KQG1 | Dihydrofolate reductase PFAM: dihydrofolate reductase region; KEGG: mex:Mext_2659 dihydrofolate reductase |
| [B] Methylobacterium extorquens (strain PA1) | METEP02615 | A9W645 | Dihydrofolate reductase |
| [B] Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001) | METPB02727 | B1ZDL8 | Dihydrofolate reductase |
| [B] Erythrobacter litoralis (strain HTCC2594) | ERYLH02702 | Q2N685 | dihydrofolate reductase COG0262 Dihydrofolate reductase |
| [B] Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) | SPHWW03738 | A5VCW5 | Dihydrofolate reductase |
| [B] Zymomonas mobilis | ZYMMO00319 | Q5NQQ9 | COG0262 dihydrofolate reductase |
| [B] Alteromonas macleodii (strain DSM 17117 / Deep ecotype) | ALTMD03676 | B4RZH2 | Dihydrofolate reductase type I, trimethoprim resistance |
| [B] Pseudoalteromonas haloplanktis (strain TAC 125) | PSEHT02582 | Q3IFF7 | Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8423162, 10408091; Product type e : enzyme dihydrofolate reductase type I, trimethoprim resistance |
| [B] Shewanella halifaxensis (strain HAW-EB4) | SHEHH00908 | B0TUI5 | Dihydrofolate reductase |
| [B] Shewanella piezotolerans (strain WP3 / JCM 13877) | SHEPW03878 | B8CSY0 | Dihydrofolate reductase |
| [B] Dichelobacter nodosus (strain VCS1703A) | DICNV00744 | A5EUV9 | Dihydrofolate reductase |
| [B] Enterobacter sp. (strain 638) | ENT3800593 | A4W6F4 | Dihydrofolate reductase |
| [B] Klebsiella pneumoniae (strain 342) | KLEP304578 | B5Y1Z7 | Dihydrofolate reductase |
| [B] Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) | KLEP700044 | A6T4I4 | Dihydrofolate reductase type I, trimethoprim resistance |
| [B] Serratia proteamaculans (strain 568) | SERP500711 | A8G9N6 | Dihydrofolate reductase |
| [B] Legionella pneumophila (strain Corby) | LEGPC00374 | A5IAH4 | Dihydrofolate reductase |
| [B] Legionella pneumophila (strain Lens) | LEGPL00350 | Q5WZM8 | dihydrofolate reductase FolA |
| [B] Legionella pneumophila (strain Paris) | LEGPA00376 | Q5X875 | dihydrofolate reductase FolA |
| [B] Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152) | LEGPH00293 | Q5ZYR2 | conserved gene dihydrofolate reductase |
| [B] Actinobacillus pleuropneumoniae serotype 3 (strain JL03) | ACTPJ00844 | B0BPG8 | Dihydrofolate reductase |
| [B] Actinobacillus pleuropneumoniae serotype 5b (strain L20) | ACTP200868 | A3N0P3 | Dihydrofolate reductase |
| [B] Actinobacillus pleuropneumoniae serotype 7 (strain AP76) | ACTP700924 | B3GXM9 | Dihydrofolate reductase |
| [B] Haemophilus ducreyi | HAEDU00957 | Q7VM78 | dihydrofolate reductase |
| [B] Haemophilus parasuis serovar 5 (strain SH0165) | HAEPS00613 | B8F4S8 | Dihydrofolate reductase |
| [B] Thiomicrospira crunogena (strain XCL-2) | THICR00571 | Q31I54 | Dihydrofolate reductase |
| [B] Xanthomonas campestris pv. campestris (strain B100) | XANCB03545 | B0RUI6 | Dihydrofolate reductase , probable |
| [B] Xanthomonas campestris pv. vesicatoria (strain 85-10) | XANC500879 | Q3BX85 | dihydrofolate reductase |
| [B] Xanthomonas oryzae (pv. oryzae) | XANOR03357 | Q5GWB6 | identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark dihydrofolate reductase type III |
| [B] Xanthomonas oryzae pv. oryzae (strain MAFF 311018) | XANOM03254 | Q2NZI1 | dihydrofolate reductase type III identified by sequence similarity; putative; ORF located using Blastx/Glimmer/GeneHacker |
| [B] Xanthomonas oryzae pv. oryzae (strain PXO99A) | XANOP01038 | B2SPT0 | Dihydrofolate reductase |
| [B] Xylella fastidiosa | XYLFA02283 | Q9PB14 | similar to SP|P12833 (percent identity: 43 %/query alignment coverage: 87.2 %/subject alignment coverage: 101.2 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -66 dihydrofolate reductase type III |
| [B] Xylella fastidiosa (strain M12) | XYLFM01315 | B0U3I9 | Dihydrofolate reductase |
| [B] Xylella fastidiosa (strain M23) | XYLF201359 | B2I6E9 | Dihydrofolate reductase |
| [B] Xylella fastidiosa (strain Temecula1 / ATCC 700964) | XYLFT01271 | Q87BT5 | Dihydrofolate reductase type III |