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OMA

Keyword Protein Sequence Group Entry

OMA Group 195138

e reductase
This group has 366 members: 1 [E]ukaryota 365 [B]acteria
Fingerprint: HMQVARA

Protein List | Alignment | Close Groups | Phyletic Profile | Ontology Download: download fasta, download darwin

[E] Ostreococcus lucimarinusOSTLU03796  UniProtKB/TrEMBL A4S155  isopentenyl diphosphate synthase, putative chloroplast precursor; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ISPH) (LYTB) go_function: oxidoreductase activity; go_process: mevalonate-independent isopentenyl diphosphate biosynthesis; isoprenoid biosynthesis
[B] Acidobacteria bacterium (strain Ellin345)ACIBL01734  UniProtKB/TrEMBL Q1IQW0  hydroxymethylbutenyl pyrophosphate reductase
[B] Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)ACIC503155  UniProtKB/TrEMBL C1F698  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Solibacter usitatus (strain Ellin6076)SOLUE01232  UniProtKB/TrEMBL Q029M3  hydroxymethylbutenyl pyrophosphate reductase KEGG: aba:Acid345_1739 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Corynebacterium diphtheriaeCORDI00915  UniProtKB/Swiss-Prot ISPH_CORDI  Similar to Escherichia coli LytB protein or B0029 or Z0034 or ECS0032 SW:LYTB_ECOLI (P22565) (316 aa) fasta scores: E(): 3.1e-54, 51.61% id in 310 aa, and to Mycobacterium tuberculosis LytB protein homolog 1 LytB1 or Rv1110 or MT1141 or MTV017.63 SW:LYB1_MYCTU (O53458) (335 aa) fasta scores: E(): 2.3e-80, 67.56% id in 333 aa Putative penicillin tolerance protein
[B] Corynebacterium efficiensCOREF01057  UniProtKB/Swiss-Prot ISPH_COREF  similar to AE006994-1|AAK45398.1| percent identity: 65 in 327 aa putative isoprenyl diphosphate biosynthesis protein IspH
[B] Corynebacterium glutamicumCORGL01686  UniProtKB/Swiss-Prot ISPH_CORGL  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Corynebacterium glutamicum (strain R)CORGB01124  UniProtKB/Swiss-Prot ISPH_CORGB  Hypothetical protein
[B] Corynebacterium jeikeium (strain K411)CORJK01388  UniProtKB/TrEMBL Q4JU85  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)CORU700613  UniProtKB/TrEMBL B1VFN9  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)MYCA901240  UniProtKB/TrEMBL B1MKQ3  Probable 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mycobacterium avium (strain 104)MYCA101165  UniProtKB/TrEMBL A0QC38  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Mycobacterium paratuberculosisMYCPA02654  UniProtKB/Swiss-Prot ISPH_MYCPA  LytB'
[B] Mycobacterium gilvum (strain PYR-GCK)MYCGI02001  UniProtKB/Swiss-Prot ISPH_MYCGI  4-hydroxy-3-methylbut-2-enyl diphosphate reductase KEGG: mmc:Mmcs_4105 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Mycobacterium lepraeMYCLE01930   NP_302306.1  Similar to M. tuberculosis LytB protein homolog lytB2 Rv1110 SW:LYB1_MYCTU (O53458) (335 aa); Fasta score E(): 0, 82.9% identity in 333 aa overlap, and to many others e.g. Escherichia coli LytB protein SW:LYTB_ECOLI (P22565) (316 aa); Fasta score E(): 0, 51.5% identity in 309 aa overlap. LytB homolog
[B] Mycobacterium leprae (strain Br4923)MYCLB01919  UniProtKB/TrEMBL B8ZSG0  LytB homolog
[B] Mycobacterium marinum (strain ATCC BAA-535 / M)MYCMM04260  UniProtKB/TrEMBL B2HT41  4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH
[B] Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)MYCS204934  UniProtKB/TrEMBL A0R2T2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mycobacterium sp. (strain JLS)MYCSJ04257  UniProtKB/Swiss-Prot ISPH_MYCSJ  hydroxymethylbutenyl pyrophosphate reductase KEGG: mmc:Mmcs_4105 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Mycobacterium sp. (strain KMS)MYCSK04087  UniProtKB/Swiss-Prot ISPH_MYCSK  hydroxymethylbutenyl pyrophosphate reductase KEGG: mmc:Mmcs_4105 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Mycobacterium sp. (strain MCS)MYCSS04066  UniProtKB/Swiss-Prot ISPH_MYCSS  Hydroxymethylbutenyl pyrophosphate reductase
[B] Mycobacterium bovisMYCBO01136  UniProtKB/Swiss-Prot ISPH1_MYCBO  Mb1140, lytB2, len: 335 aa. Equivalent to Rv1110, len: 335 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 335 aa overlap). Probable lytB2, LytB-related protein, equivalent to AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa), FASTA score: (82.9% identity in 333 aa overlap). Also similar to LytB proteins from many bacteria (appears to have N-terminal extension) e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN from Escherichia coli strains K12 and O157:H7 (316 aa), FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa overlap); etc. Also very similar to another LytB-related protein from Mycobacterium tuberculosis: LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975, E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY. PROBABLE LYTB-RELATED PROTEIN LYTB2
[B] Mycobacterium bovis (strain BCG / Paris 1173P2)MYCBP01143  UniProtKB/TrEMBL A1KHQ0  Probable lytB-related protein lytB2
[B] Mycobacterium tuberculosisMYCTU02325  UniProtKB/Swiss-Prot ISPH1_MYCTU  4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
[B] Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)MYCTA01128  UniProtKB/TrEMBL A5U1F7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mycobacterium tuberculosis (strain F11)MYCTF01100  UniProtKB/TrEMBL A5WLD6  lytB-related protein lytB2 Mapped to H37Rv Rv1110
[B] Mycobacterium ulcerans (strain Agy99)MYCUA00139  UniProtKB/Swiss-Prot ISPH_MYCUA  4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH cytoplasmic protein converts 1-hydroxy-2-methyl-2-(E)-butenyl 4- diphosphate into isopentenyl diphosphate (Ipp) and dimethylallyl diphosphate (DMAPP) (by similarity)[catalytic activity] isopentenyl diphosphate + NAD(P)(+) + H(2)O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. [cofactor] binds 1 3Fe-4S cluster (by similarity)[pathway] isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from 1- hydroxy-2-methyl-2-butenyl 4-diphosphate: single step [final step][pathway] isoprenoid biosynthesis; isopentenyl-PP biosynthesis via DXP pathway; isopentenyl- PP from 1-deoxy-D-xylulose 5-phosphate:step 6 [final step]
[B] Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)MYCVP04479  UniProtKB/Swiss-Prot ISPH_MYCVP  hydroxymethylbutenyl pyrophosphate reductase KEGG: mmc:Mmcs_4105 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Nocardia farcinicaNOCFA04802  UniProtKB/Swiss-Prot ISPH_NOCFA  putative isoprenoid biosynthesis protein
[B] Rhodococcus erythropolis (strain PR4 / NBRC 100887)RHOE404224  UniProtKB/Swiss-Prot ISPH_RHOE4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Rhodococcus opacus (strain B4)RHOOB05927  UniProtKB/Swiss-Prot ISPH_RHOOB  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Rhodococcus sp. (strain RHA1)RHOSR05782  UniProtKB/Swiss-Prot ISPH_RHOSR  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acidothermus cellulolyticus (strain ATCC 43068 / 11B)ACIC101854  UniProtKB/Swiss-Prot ISPH_ACIC1  hydroxymethylbutenyl pyrophosphate reductase KEGG: fra:Francci3_3881 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Frankia alni (strain ACN14a)FRAAA06001  UniProtKB/TrEMBL Q0RCQ1  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
[B] Frankia sp. (strain CcI3)FRASC03769  UniProtKB/TrEMBL Q2J661  hydroxymethylbutenyl pyrophosphate reductase
[B] Frankia sp. (strain EAN1pec)FRASN00826  UniProtKB/TrEMBL A8L187  Hydroxymethylbutenyl pyrophosphate reductase
[B] Tropheryma whipplei (strain TW08/27)TROW800628  UniProtKB/Swiss-Prot ISPH_TROW8  Similar to Escherichia coli IspH protein or LytB or b0029 or z0034 or ecs0032 SWALL:BAB96598 (EMBL:AY062212) (316 aa) fasta scores: E(): 2.5e-51, 49.83% id in 309 aa, and to Mycobacterium tuberculosis IspH protein 1 or LytB1 or Rv1110 or mt1141 or mtv017.63 SWALL:ISH1_MYCTU (SWALL:O53458) (335 aa) fasta scores: E(): 8.4e-75, 67.41% id in 310 aa IspH protein
[B] Tropheryma whipplei (strain Twist)TROWT00640  UniProtKB/Swiss-Prot ISPH_TROWT  nonmevalonate terpenoid biosynthesis pathway IspH protein 1
[B] Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)CLAM302252  UniProtKB/TrEMBL A5CT73  IspH protein
[B] Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667)CLAMS02317  UniProtKB/TrEMBL B0RH21  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Leifsonia xyli (subsp. xyli)LEIXX01318  UniProtKB/Swiss-Prot ISPH_LEIXX  identified by sequence similarity penicillin-tolerance protein
[B] Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)ARTCA02508  UniProtKB/TrEMBL B8HC97  Hydroxymethylbutenyl pyrophosphate reductase
[B] Arthrobacter sp. (strain FB24)ARTS202806  UniProtKB/TrEMBL A0JYU2  hydroxymethylbutenyl pyrophosphate reductase KEGG: lxx:Lxx16760 penicillin-tolerance protein TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / IFO 15589)RENSM01096  UniProtKB/TrEMBL A9WPD7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Salinispora arenicola (strain CNS-205)SALAI00805  UniProtKB/TrEMBL A8M2X4  Hydroxymethylbutenyl pyrophosphate reductase
[B] Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)SALTO00871  UniProtKB/TrEMBL A4X3A6  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Nocardioides sp. (strain BAA-499 / JS614)NOCSJ01037  UniProtKB/TrEMBL A1SFK8  Hydroxymethylbutenyl pyrophosphate reductase
[B] Propionibacterium acnesPROAC00562  UniProtKB/Swiss-Prot ISPH_PROAC  IspH, non-mevalonate pathway of isoprenoid biosynthesis
[B] Saccharopolyspora erythraea (strain NRRL 23338)SACEN00908  UniProtKB/TrEMBL A4F898  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Phytoplasma sp. (strain STRAWB1)STRAW03209  UniProtKB/Swiss-Prot ISPH_STRAW  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Streptomyces coelicolorSTRCO05028  UniProtKB/Swiss-Prot ISPH_STRCO  SCBAC20F6.01, lytB, len: >148 aa; highly similar to C-terminal region of SW:LYTB_ECOLI (EMBL:X54945) Escherichia coli LytB protein LytB or B0029, 316 aa; fasta scores: opt: 434 Z-score: 512.5 bits: 101.9 E(): 5.9e-21; 51.145% identity in 131 aa overlap. Contains Pfam match to entry PF02401 LYTB, LytB protein SCK7.31, hypothetical protein (fragment), len: >224 aa; similar to SW:LYTB_ECOLI (EMBL:AE000113) Escherichia coli regulator, control of stringent response; involved in penicillin tolerance LytB protein, 316 aa; fasta scores: opt: 781 z-score: 922.7 E(): 0; 53.2% identity in 216 aa overlap hypothetical protein
[B] Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)STRGG02345  UniProtKB/Swiss-Prot ISPH_STRGG  Putative 4-hydroxy-3-methylbut-2-enyl diphosphate
[B] Thermobifida fusca (strain YX)THEFY00469  UniProtKB/TrEMBL Q47SQ8  LytB protein
[B] Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083)BIFAA01078  UniProtKB/TrEMBL A1A2C9  4-hydroxy-3-methylbut-2-enyl diphosphate reductase COG family: penicillin toleranceprotein Orthologue of BL1361 PFAM_ID: LYTB
[B] Bifidobacterium longum (strain DJO10A)BIFLD00220  UniProtKB/TrEMBL B3DQS7  4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Symbiobacterium thermophilumSYMTH00892  UniProtKB/Swiss-Prot ISPH_SYMTH  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
[B] Aquifex aeolicusAQUAE01201  UniProtKB/Swiss-Prot ISPH_AQUAE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Hydrogenobaculum sp. (strain Y04AAS1)HYDS001041  UniProtKB/TrEMBL B4U9C3  Hydroxymethylbutenyl pyrophosphate reductase
[B] Sulfurihydrogenibium sp. (strain YO3AOP1)SULSY01101  UniProtKB/TrEMBL B2V9Y7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Chlamydia muridarumCHLMU00242  UniProtKB/Swiss-Prot ISPH_CHLMU  similar to GB:M65217, SP:Q03933, and PID:184405; identified by sequence similarity; putative penicillin tolerance protein LytB
[B] Chlamydia pneumoniaeCHLPN01428  UniProtKB/Swiss-Prot ISPH_CHLPN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Chlamydophila abortusCHLAB00699  UniProtKB/Swiss-Prot ISPH_CHLAB  Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 IspH protein IspH or LytB or b0029 or c0033 or z0034 or ecs0032 SWALL:ISPH_ECOLI (SWALL:P22565) (316 aa) fasta scores: E(): 1.9e-46, 46.6% id in 309 aa, and to Chlamydophila caviae hydroxymethylbutenyldiphosphate reductase IspH or cca00744 SWALL:Q822D9 (EMBL:AE016996) (309 aa) fasta scores: E(): 7.1e-110, 93.83% id in 308 aa, and to Chlamydia pneumoniae IspH protein IspH or LytB or cpn1017 or cp0836 SWALL:ISPH_CHLPN (SWALL:Q9Z6P2) (310 aa) fasta scores: E(): 5.4e-86, 73.7% id in 308 aa putative IspH/LytB protein
[B] Chlamydophila caviaeCHLCV00731  UniProtKB/Swiss-Prot ISPH_CHLCV  identified by match to PFAM protein family HMM PF02599 hydroxymethylbutenyldiphosphate reductase
[B] Parachlamydia sp. (strain UWE25) (subsp. Acanthamoeba sp.)PARUW01078  UniProtKB/Swiss-Prot ISPH_PARUW  strongly similar to protein involved in isoprenoid biosynthesis and penicillin tolerance probable protein involved in isoprenoid biosynthesis and penicillin tolerance
[B] Dehalococcoides ethenogenes (strain 195)DEHE101220  UniProtKB/Swiss-Prot ISPH_DEHE1  identified by similarity to SP:P22565; match to protein family HMM PF02401; match to protein family HMM TIGR00216 hydroxymethylbutenyl pyrophosphate reductase
[B] Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)THERP01603  UniProtKB/TrEMBL B9L0G7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Cyanothece (strain ATCC 51142)CYAA501091  UniProtKB/Swiss-Prot ISPH_CYAA5  Putative LytB protein
[B] Cyanothece sp. (strain PCC 7425 / ATCC 29141)CYAP402082  UniProtKB/Swiss-Prot ISPH_CYAP4  Hydroxymethylbutenyl pyrophosphate reductase
[B] Microcystis aeruginosa (strain NIES-843)MICAN01495  UniProtKB/Swiss-Prot ISPH_MICAN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)SYNP200506  UniProtKB/Swiss-Prot ISPH_SYNP2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Synechococcus sp. (strain CC9605)SYNSC00239  UniProtKB/Swiss-Prot ISPH_SYNSC  hydroxymethylbutenyl pyrophosphate reductase
[B] Synechococcus sp. (strain WH7803)SYNPW00296  UniProtKB/Swiss-Prot ISPH_SYNPW  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Nostoc punctiforme (strain ATCC 29133 / PCC 73102)NOSP702857  UniProtKB/Swiss-Prot ISPH_NOSP7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Prochlorococcus marinusPROMA00296  UniProtKB/Swiss-Prot ISPH_PROMA  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Prochlorococcus marinus (strain MIT 9211)PROM400292  UniProtKB/Swiss-Prot ISPH_PROM4  LytB-like protein
[B] Prochlorococcus marinus (strain MIT 9303)PROM302445  UniProtKB/Swiss-Prot ISPH_PROM3  LytB
[B] Prochlorococcus marinus (strain MIT 9313)PROMM01845  UniProtKB/Swiss-Prot ISPH_PROMM  Citation: McAteer et al. (2001) J. Bacteriol. 183(24):7403-7407. LytB protein homolog
[B] Prochlorococcus marinus (strain NATL1A)PROM100342  UniProtKB/Swiss-Prot ISPH_PROM1  LytB
[B] Prochlorococcus marinus (strain NATL2A)PROMT00321  UniProtKB/Swiss-Prot ISPH_PROMT  LytB protein
[B] Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)DICT600993  UniProtKB/Swiss-Prot ISPH_DICT6  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Dictyoglomus turgidum (strain Z-1310 / DSM 6724)DICTD01095  UniProtKB/Swiss-Prot ISPH_DICTD  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Bacillus anthracisBACAN04156  UniProtKB/Swiss-Prot ISPH_BACAN  similar to GB:M65217, SP:Q03933, and PID:184405; identified by sequence similarity; putative penicillin tolerance protein LytB
[B] Bacillus cereus (strain AH187)BACC704195  UniProtKB/Swiss-Prot ISPH_BACC7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Bacillus cereus (strain ATCC 10987)BACC104324  UniProtKB/Swiss-Prot ISPH_BACC1  identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216 penicillin tolerance protein LytB
[B] Bacillus cereus (strain G9842)BACC204300  UniProtKB/Swiss-Prot ISPH_BACC2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Bacillus cereus (strain ZK)BACCZ03998  UniProtKB/Swiss-Prot ISPH_BACCZ  penicillin tolerance protein; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Bacillus haloduransBACHD01356  UniProtKB/Swiss-Prot ISPH_BACHD  penicillin tolerance protein
[B] Bacillus licheniformis (strain DSM 13 / ATCC 14580)BACLD02551  UniProtKB/Swiss-Prot ISPH_BACLD  LytB protein homolog; Biological Process: isopentenyl diphosphate biosynthesis, mevalonate-independent (GO:0005506@[IEA]; GO:0016114@[IEA]; GO:0019288@[IEA]; GO:0051538@[IEA]; GO:0051745@[IEA]; GO:0055114@[IEA]) isopentenyl diphosphate biosynthesis protein IspH
[B] Bacillus subtilisBACSU02515   CAB14446.1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Bacillus thuringiensis (subsp. konkukian)BACHK03962  UniProtKB/Swiss-Prot ISPH_BACHK  Structural feature(s) predicted by Psort:Cleavable N-term signal seq: 4092430 - 4092451 penicillin tolerance protein, 4-hydroxy-3-methylbut-2-enyl diphosphate
[B] Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)EXIS200826  UniProtKB/Swiss-Prot ISPH_EXIS2  Hydroxymethylbutenyl pyrophosphate reductase
[B] Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)BREBN04861  UniProtKB/Swiss-Prot ISPH_BREBN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Alkaliphilus metalliredigens (strain QYMF)ALKMQ02395  UniProtKB/Swiss-Prot ISPH_ALKMQ  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Alkaliphilus oremlandii (strain OhILAs)ALKOO01532  UniProtKB/Swiss-Prot ISPH_ALKOO  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Clostridium difficile (strain 630)CLOD601833  UniProtKB/Swiss-Prot ISPH_CLOD6  putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Clostridium perfringensCLOPE01085  UniProtKB/Swiss-Prot ISPH_CLOPE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Clostridium perfringens (strain ATCC 13124 / NCTC 8237)CLOP101310  UniProtKB/Swiss-Prot ISPH_CLOP1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Clostridium perfringens (strain SM101)CLOPS01113  UniProtKB/Swiss-Prot ISPH_CLOPS  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)THEP301111  UniProtKB/Swiss-Prot ISPH_THEP3  Hydroxymethylbutenyl pyrophosphate reductase
[B] Thermoanaerobacter sp. (strain X514)THEPX01544  UniProtKB/Swiss-Prot ISPH_THEPX  Hydroxymethylbutenyl pyrophosphate reductase
[B] Thermoanaerobacter tengcongensisTHETN01224  UniProtKB/Swiss-Prot ISPH_THETN  Best Blastp hit = gi|8928180|sp|O67625|LYTB_AQUAE LYTB PROTEIN HOMOLOG gi|7445056|pir||G70449 LytB protein - Aquifex aeolicus gi|2984055|gb|AAC07596.1| (AE000754) LytB protein [Aquifex aeolicus], score 226, E-value 3.00E-58 Penicillin tolerance protein
[B] Rhodopirellula balticaRHOBA05096  UniProtKB/Swiss-Prot ISPH_RHOBA  PMID: 11818558 best DB hits: BLAST: pir:G83076; LytB protein PA4557 [imported] - Pseudomonas aeruginosa; E=4e-81 gb:AAD55804.1; (AF027189) LytB [Acinetobacter sp. BD413]; E=1e-80 pir:G82293; lytB protein VC0685 [imported] - Vibrio cholerae (group; E=7e-77 COG: PA4557; COG0761 Penicillin tolerance protein; E=4e-82 PFAM: PF02401; LytB protein; E=2.4e-132 LytB protein
[B] Anaplasma marginale (strain St. Maries)ANAMM00539  UniProtKB/Swiss-Prot ISPH_ANAMM  COG0761 LytB penicillin tolerance protein; go_process: 0019288 lytB protein
[B] Ehrlichia canis (strain Jake)EHRCJ00510  UniProtKB/TrEMBL Q3YRU3  LytB protein
[B] Ehrlichia chaffeensis (strain Arkansas)EHRCR00479  UniProtKB/TrEMBL Q2GGW6  hydroxymethylbutenyl pyrophosphate reductase identified by similarity to SP:P22565; match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Neorickettsia sennetsu (strain Miyayama)NEOSM00419  UniProtKB/Swiss-Prot ISPH_NEOSM  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by similarity to SP:P22565; match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Wolbachia pipientis subsp. Culex pipiens (strain wPip)WOLPP00696  UniProtKB/Swiss-Prot ISPH_WOLPP  Penicillin tolerance protein LytB
[B] Wolbachia pipientis wMelWOLPM01113  UniProtKB/Swiss-Prot ISPH_WOLPM  Identified by similarity to EGAD:19519; match to PF02401 protein family HMM PF02401; match to TIGR00216 protein family HMM TIGR00216 penicillin tolerance protein LytB
[B] Wolbachia sp. (subsp. Brugia malayi) (strain TRS)WOLTR00046  UniProtKB/Swiss-Prot ISPH_WOLTR  4-Hydroxy-3-methylbut-2-enyl diphosphate reductase, IspH
[B] Wolbachia sp. subsp. Drosophila simulans (strain wRi)WOLWR00940  UniProtKB/Swiss-Prot ISPH_WOLWR  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Erythrobacter litoralis (strain HTCC2594)ERYLH00308  UniProtKB/TrEMBL Q2ND37  4-hydroxy-3-methylbut-2-enyl diphosphate reductase COG0761 Penicillin tolerance protein
[B] Bordetella avium (strain 197N)BORA102387  UniProtKB/TrEMBL Q2KXW8  4-hydroxy-3-methylbut-2-enyl diphosphate reductase (putative drug tolerance protein)
[B] Bordetella bronchisepticaBORBR03240  UniProtKB/Swiss-Prot ISPH_BORBR  ortholog of Bordetella pertussis (BX470248) BP1237 putative drug tolerance protein
[B] Bordetella parapertussisBORPA01838  UniProtKB/Swiss-Prot ISPH_BORPA  ortholog of Bordetella pertussis (BX470248) BP1237 putative drug tolerance protein
[B] Bordetella pertussisBORPE01125  UniProtKB/Swiss-Prot ISPH_BORPE  Similar to Escherichia coli LytB protein LytB or B0029 or Z0034 or Ecs0032 SW:LYTB_ECOLI (P22565) (316 aa) fasta scores: E(): 5e-67, 59.04% id in 315 aa, and to Xylella fastidiosa drug tolerance protein Xf2416 TR:Q9PAS9 (EMBL:AE004050) (316 aa) fasta scores: E(): 6.6e-73, 64.4% id in 309 aa putative drug tolerance protein
[B] Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)BORPD03081  UniProtKB/TrEMBL A9IU20  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Burkholderia ambifaria (strain MC40-6)BURA402386  UniProtKB/TrEMBL B1YV91  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia cenocepacia (strain AU 1054)BURCA01867  UniProtKB/TrEMBL Q1BUB4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Burkholderia cenocepacia (strain HI2424)BURCH02484  UniProtKB/TrEMBL A0K9S2  hydroxymethylbutenyl pyrophosphate reductase KEGG: bcn:Bcen_1888 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Burkholderia cenocepacia (strain MC0-3)BURCC02498  UniProtKB/TrEMBL B1JXB0  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia cepacia (strain ATCC 53795 / AMMD)BURCM02535  UniProtKB/TrEMBL Q0BCM1  hydroxymethylbutenyl pyrophosphate reductase KEGG: bur:Bcep18194_A5831 4-hydroxy-3-methylbut-2-enyl diphosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Burkholderia cepacia (strain J2315 / LMG 16656)BURCJ02594  UniProtKB/TrEMBL B4E8Y4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
[B] Burkholderia sp. (strain 383)BURS302638  UniProtKB/TrEMBL Q39DP1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Burkholderia vietnamiensis (strain G4 / LMG 22486)BURVG02486  UniProtKB/TrEMBL A4JH19  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia malleiBURMA01834  UniProtKB/Swiss-Prot ISPH2_BURMA  4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
[B] Burkholderia mallei (strain NCTC 10229)BURM900953  UniProtKB/TrEMBL A2S4Y6  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia mallei (strain NCTC 10247)BURM701966  UniProtKB/TrEMBL A3MMZ2  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia mallei (strain SAVP1)BURMS02479  UniProtKB/TrEMBL A1V6T8  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia phymatum (strain DSM 17167 / STM815)BURP800581  UniProtKB/TrEMBL B2JE02  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia phytofirmans (strain DSM 17436 / PsJN)BURPP03062  UniProtKB/TrEMBL B2T6H4  Hydroxymethylbutenyl pyrophosphate reductase
[B] Burkholderia pseudomalleiBURPS00923  UniProtKB/Swiss-Prot ISPH1_BURPS  Similar to Acinetobacter calcoaceticus IspH protein ispH or lytB SWALL:ISPH_ACICA (SWALL:Q9RBJ0) (316 aa) fasta scores: E(): 4.9e-69, 61.29% id in 310 aa, and to Ralstonia solanacearum IspH protein rsc2442 or rs01352 SWALL:ISPH_RALSO (SWALL:P58677) (324 aa) fasta scores: E(): 1.4e-87, 72.84% id in 324 aa, and to Xanthomonas axonopodis IspH protein ispH or lytB or xac1256 SWALL:AAM36128 (EMBL:AE011755) (316 aa) fasta scores: E(): 1.1e-70, 63.34% id in 311 aa LytB protein
[B] Burkholderia pseudomallei (strain 1106a)BURP000977  UniProtKB/TrEMBL A3NSE6  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Burkholderia pseudomallei (strain 1710b)BURP101119  UniProtKB/TrEMBL Q3JV50  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Burkholderia pseudomallei (strain 668)BURP600976  UniProtKB/TrEMBL A3N6R1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)BURTA00772  UniProtKB/TrEMBL Q2T0G0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Burkholderia xenovorans (strain LB400)BURXL03487  UniProtKB/TrEMBL Q13UX5  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Cupriavidus taiwanensis (strain R1 / LMG 19424)CUPTR02443  UniProtKB/TrEMBL B3R6F5  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein
[B] Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)RALEH02950  UniProtKB/TrEMBL Q0K7B5  penicillin tolerance protein
[B] Ralstonia eutropha (strain JMP134)RALEJ02700  UniProtKB/TrEMBL Q46XP2  LytB protein
[B] Polynucleobacter necessarius (strain STIR1)POLNS01212  UniProtKB/TrEMBL B1XW17  Hydroxymethylbutenyl pyrophosphate reductase
[B] Polynucleobacter sp. (strain QLW-P1DMWA-1)POLSQ01719  UniProtKB/TrEMBL A4SZN0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Ralstonia pickettii (strain 12J)RALPJ02605  UniProtKB/TrEMBL B2UAN8  Hydroxymethylbutenyl pyrophosphate reductase
[B] Ralstonia solanacearumRALSO02417  UniProtKB/Swiss-Prot ISPH_RALSO  Product confidence : probable Gene name confidence : probable predicted by Codon_usage predicted by Homology predicted by FrameD PROBABLE LYTB PROTEIN
[B] Acidovorax avenae subsp. citrulli (strain AAC00-1)ACIAC03596  UniProtKB/TrEMBL A1TTN0  hydroxymethylbutenyl pyrophosphate reductase KEGG: pol:Bpro_0951 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Acidovorax sp. (strain JS42)ACISJ03197  UniProtKB/TrEMBL A1WBD7  hydroxymethylbutenyl pyrophosphate reductase KEGG: pol:Bpro_0951 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Delftia acidovorans (strain DSM 14801 / SPH-1)DELAS01889  UniProtKB/TrEMBL A9BYK3  Hydroxymethylbutenyl pyrophosphate reductase
[B] Diaphorobacter sp. (strain TPSY)DIAST02702  UniProtKB/TrEMBL B9MEH0  Hydroxymethylbutenyl pyrophosphate reductase
[B] Polaromonas naphthalenivorans (strain CJ2)POLNA03267  UniProtKB/TrEMBL A1VSK6  Hydroxymethylbutenyl pyrophosphate reductase
[B] Polaromonas sp. (strain JS666 / ATCC BAA-500)POLSJ00934  UniProtKB/Swiss-Prot ISPH_POLSJ  hydroxymethylbutenyl pyrophosphate reductase
[B] Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118)RHOFD03178  UniProtKB/TrEMBL Q21TE6  hydroxymethylbutenyl pyrophosphate reductase
[B] Verminephrobacter eiseniae (strain EF01-2)VEREI01598  UniProtKB/TrEMBL A1WIF2  Hydroxymethylbutenyl pyrophosphate reductase
[B] Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)LEPCP00690  UniProtKB/TrEMBL B1Y0I7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Methylibium petroleiphilum (strain PM1)METPP02645  UniProtKB/Swiss-Prot ISPH_METPP  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Herminiimonas arsenicoxydansHERAR02343  UniProtKB/TrEMBL A4G7V7  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein
[B] Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)JANMA02548  UniProtKB/TrEMBL A6T142  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Thiobacillus denitrificans (strain ATCC 25259)THIDA01859  UniProtKB/TrEMBL Q3SHS0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, LytB protein
[B] Methylobacillus flagellatus (strain KT / ATTC 51484 / DSM 6875)METFK02280  UniProtKB/TrEMBL Q1GYJ1  hydroxymethylbutenyl pyrophosphate reductase
[B] Chromobacterium violaceumCHRVO03559  UniProtKB/Swiss-Prot ISPH_CHRVO  identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0761 lytB protein
[B] Laribacter hongkongensis (strain HLHK9)LARHH00591  UniProtKB/TrEMBL C1DCX4  IspH
[B] Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)NEIG100062  UniProtKB/Swiss-Prot ISPH_NEIG1  LytB; Best Blastp Hit: possibly phase variable - 8G residue homopolymer repeat in the coding sequence (ON) COG0761 Penicillin tolerance protein LytB putative penicillin tolerance protein
[B] Neisseria gonorrhoeae (strain NCCP11945)NEIG200102  UniProtKB/Swiss-Prot ISPH_NEIG2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Neisseria meningitidis serogroup ANEIMA00556  UniProtKB/Swiss-Prot ISPH_NEIMA  LytB protein
[B] Neisseria meningitidis serogroup BNEIMB01688  UniProtKB/Swiss-Prot ISPH_NEIMB  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Neisseria meningitidis serogroup C (strain 053442)NEIM000362  UniProtKB/Swiss-Prot ISPH_NEIM0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase Code: IM; COG: COG0761
[B] Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18)NEIMF00348  UniProtKB/Swiss-Prot ISPH_NEIMF  LytB protein
[B] Nitrosomonas europaeaNITEU00627  UniProtKB/Swiss-Prot ISPH_NITEU  LytB protein
[B] Nitrosomonas eutropha (strain C71)NITEC01789  UniProtKB/TrEMBL Q0AEU7  hydroxymethylbutenyl pyrophosphate reductase KEGG: neu:NE0649 LytB protein TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)NITMU00084  UniProtKB/TrEMBL Q2YCX3  hydroxymethylbutenyl pyrophosphate reductase
[B] Azoarcus sp. (strain BH72)AZOSB01198  UniProtKB/Swiss-Prot ISPH_AZOSB  probable 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2). Function:- Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity). InterPro: LytB protein lytB: penicillin tolerance protein LytB SWISSPROT:ISPH_ECOLI Prim. accession # P22565 Identities = 185/308 (60%) InterPro IPR003451; LytB. Pfam PF02401; LYTB; 1. TIGRFAMs TIGR00216; ispH_lytB; 1. TMHMM 0.0, Signal peptide probability: 0.000 Prediction: Non-secretory protein Family membership
[B] Azoarcus sp. (strain EbN1)AZOSE02448  UniProtKB/Swiss-Prot ISPH_AZOSE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2),gene: ISPH OR LYTB OR RSC2442 OR RS01352
[B] Dechloromonas aromatica (strain RCB)DECAR02992  UniProtKB/Swiss-Prot ISPH_DECAR  LytB protein
[B] Desulfovibrio desulfuricans (strain G20)DESDG00390  UniProtKB/Swiss-Prot ISPH_DESDG  hydroxymethylbutenyl pyrophosphate reductase
[B] Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)GEOBB03211  UniProtKB/Swiss-Prot ISPH_GEOBB  Hydroxymethylbutenyl pyrophosphate reductase
[B] Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)GEOMG00839  UniProtKB/Swiss-Prot ISPH_GEOMG  LytB protein
[B] Geobacter sulfurreducensGEOSL02561  UniProtKB/Swiss-Prot ISPH_GEOSL  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Geobacter uraniumreducens (strain Rf4)GEOUR01406  UniProtKB/Swiss-Prot ISPH_GEOUR  Hydroxymethylbutenyl pyrophosphate reductase
[B] Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)PELCD02012  UniProtKB/Swiss-Prot ISPH_PELCD  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Anaeromyxobacter dehalogenans (strain 2CP-C)ANADE01513  UniProtKB/TrEMBL Q2II11  hydroxymethylbutenyl pyrophosphate reductase
[B] Anaeromyxobacter sp. (strain K)ANASK02326  UniProtKB/Swiss-Prot ISPH_ANASK  Hydroxymethylbutenyl pyrophosphate reductase
[B] Arcobacter butzleri (strain RM4018)ARCB401979  UniProtKB/TrEMBL A8EWE4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter concisus (strain 13826)CAMC100544  UniProtKB/Swiss-Prot ISPH_CAMC1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter curvus (strain 525.92)CAMC500553  UniProtKB/Swiss-Prot ISPH_CAMC5  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter fetus subsp. fetus (strain 82-40)CAMFF01194  UniProtKB/Swiss-Prot ISPH_CAMFF  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)CAMHC00449  UniProtKB/Swiss-Prot ISPH_CAMHC  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter jejuniCAMJE00834  UniProtKB/Swiss-Prot ISPH_CAMJE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter jejuni (strain RM1221)CAMJR00940  UniProtKB/Swiss-Prot ISPH_CAMJR  identified by similarity to SP:P22565; match to protein family HMM PF02401; match to protein family HMM TIGR00216 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)CAMJD00744  UniProtKB/Swiss-Prot ISPH_CAMJD  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)CAMJJ00840  UniProtKB/Swiss-Prot ISPH_CAMJJ  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)CAMJ800825  UniProtKB/Swiss-Prot ISPH_CAMJ8  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)CAMLR01145  UniProtKB/Swiss-Prot ISPH_CAMLR  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Helicobacter acinonychis (strain Sheeba)HELAH00420  UniProtKB/TrEMBL Q17YI7  (O25160) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) High confidence in function and specificity
[B] Helicobacter hepaticusHELHP00137  UniProtKB/Swiss-Prot ISPH_HELHP  penicillin tolerance protein LytB
[B] Helicobacter pyloriHELPY00396  UniProtKB/Swiss-Prot ISPH_HELPY  similar to GB:L42023 SP:P44976 PID:1006215 PID:1221120 PID:1205257 percent identity: 30.58; identified by sequence similarity; putative penicillin tolerance protein (lytB)
[B] Helicobacter pylori (strain G27)HELPG00970  UniProtKB/TrEMBL B5Z851  Isoprenyl pyrophosphate and dimethyl allyldiphosphate synthetase
[B] Helicobacter pylori (strain HPAG1)HELPH00990  UniProtKB/Swiss-Prot ISPH_HELPH  isoprenyl pyrophosphate and dimethylallyl diphosphate synthetase
[B] Helicobacter pylori (strain Shi470)HELPS01020  UniProtKB/Swiss-Prot ISPH_HELPS  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Helicobacter pylori J99HELPJ00977  UniProtKB/Swiss-Prot ISPH_HELPJ  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)SULDN00855  UniProtKB/Swiss-Prot ISPH_SULDN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Nitratiruptor sp. (strain SB155-2)NITSB00662  UniProtKB/Swiss-Prot ISPH_NITSB  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Sulfurovum sp. (strain NBC37-1)SULNB00547  UniProtKB/Swiss-Prot ISPH_SULNB  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455)ACIF203068  UniProtKB/Swiss-Prot ISPH_ACIF2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acidithiobacillus ferrooxidans (strain ATCC 53993)ACIF502700  UniProtKB/Swiss-Prot ISPH_ACIF5  Hydroxymethylbutenyl pyrophosphate reductase
[B] Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)AERHH00660  UniProtKB/Swiss-Prot ISPH_AERHH  4-hydroxy-3-methylbut-2-enyl diphosphate reductase identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216
[B] Aeromonas salmonicida (strain A449)AERS400619  UniProtKB/Swiss-Prot ISPH_AERS4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Alteromonas macleodii (strain DSM 17117 / Deep ecotype)ALTMD02977  UniProtKB/TrEMBL B4RVN9  4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8)MARAV00812  UniProtKB/Swiss-Prot ISPH_MARAV  hydroxymethylbutenyl pyrophosphate reductase KEGG: hch:HCH_05930 4-hydroxy-3-methylbut-2-enyl diphosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)SACD202548  UniProtKB/Swiss-Prot ISPH_SACD2  Elongation factor Ts
[B] Colwellia psychrerythraea (strain 34H / ATCC BAA-681)COLP301150  UniProtKB/Swiss-Prot ISPH_COLP3  identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Idiomarina loihiensisIDILO01115  UniProtKB/Swiss-Prot ISPH_IDILO  4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudoalteromonas atlantica (strain T6c / BAA-1087)PSEA603138  UniProtKB/Swiss-Prot ISPH_PSEA6  Hydroxymethylbutenyl pyrophosphate reductase
[B] Pseudoalteromonas haloplanktis (strain TAC 125)PSEHT00885  UniProtKB/Swiss-Prot ISPH_PSEHT  Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11818558; Product type e : enzyme 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Psychromonas ingrahamii (strain 37)PSYIN03069  UniProtKB/Swiss-Prot ISPH_PSYIN  hydroxymethylbutenyl pyrophosphate reductase KEGG: pha:PSHAa0921 4-hydroxy-3-methylbut-2-enyl diphosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)SHEAM00919  UniProtKB/TrEMBL A1S428  4-hydroxy-3-methylbut-2-enyl diphosphate reductase KEGG: son:SO3529 penicillin tolerance protein LytB
[B] Shewanella baltica (strain OS155 / ATCC BAA-1091)SHEB501018  UniProtKB/TrEMBL A3D1G8  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella baltica (strain OS185)SHEB801095  UniProtKB/TrEMBL A6WKD7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella baltica (strain OS195)SHEB901146  UniProtKB/TrEMBL A9L4V0  KEGG: shw:Sputw3181_3103 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella baltica (strain OS223)SHEB203133  UniProtKB/TrEMBL B8EFC4  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)SHEDO02676  UniProtKB/TrEMBL Q12KM7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella frigidimarina (strain NCIMB 400)SHEFN02837  UniProtKB/TrEMBL Q07Z38  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella halifaxensis (strain HAW-EB4)SHEHH01126  UniProtKB/Swiss-Prot ISPH_SHEHH  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella loihica (strain BAA-1088 / PV-4)SHELP01099  UniProtKB/TrEMBL A3QBX5  hydroxymethylbutenyl pyrophosphate reductase KEGG: shm:Shewmr7_3036 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Shewanella oneidensisSHEON03303  UniProtKB/Swiss-Prot ISPH_SHEON  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Shewanella pealeana (strain ANG-SQ1 / ATCC 700345)SHEPA01066  UniProtKB/Swiss-Prot ISPH_SHEPA  KEGG: slo:Shew_1102 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella piezotolerans (strain WP3 / JCM 13877)SHEPW03531  UniProtKB/TrEMBL B8CSB8  LytB protein
[B] Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)SHEPC01035  UniProtKB/TrEMBL A4Y4A7  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella sediminis (strain HAW-EB3)SHESH01193  UniProtKB/TrEMBL A8FSI5  KEGG: slo:Shew_1102 hydroxymethylbutenyl pyrophosphate reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Shewanella sp. (strain ANA-3)SHESA03094  UniProtKB/TrEMBL A0KZY8  hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein KEGG: son:SO3529 penicillin tolerance protein LytB
[B] Shewanella sp. (strain MR-4)SHESM02937  UniProtKB/TrEMBL Q0HFZ2  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella sp. (strain MR-7)SHESR03004  UniProtKB/TrEMBL Q0HS85  Hydroxymethylbutenyl pyrophosphate reductase
[B] Shewanella sp. (strain W3-18-1)SHESW03032  UniProtKB/TrEMBL A1RMM3  hydroxymethylbutenyl pyrophosphate reductase KEGG: shm:Shewmr7_3036 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Shewanella woodyi (strain ATCC 51908 / MS32)SHEWM01280  UniProtKB/TrEMBL B1KIT8  Hydroxymethylbutenyl pyrophosphate reductase
[B] Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)NITOC01640  UniProtKB/TrEMBL Q3JAD0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Alkalilimnicola ehrlichei (strain MLHE-1)ALHEH00848  UniProtKB/TrEMBL Q0AAC9  Hydroxymethylbutenyl pyrophosphate reductase
[B] Halorhodospira halophila (strain DSM 244 / SL1)HALHL01801  UniProtKB/TrEMBL A1WY36  Hydroxymethylbutenyl pyrophosphate reductase
[B] Thioalkalivibrio sp. (strain HL-EbGR7)THISH03172  UniProtKB/Swiss-Prot ISPH_THISH  Hydroxymethylbutenyl pyrophosphate reductase
[B] Buchnera aphidicola (subsp. Acyrthosiphon pisum)BUCAI00137  UniProtKB/Swiss-Prot ISPH_BUCAI  LytB protein
[B] Buchnera aphidicola (subsp. Schizaphis graminum)BUCAP00137  UniProtKB/Swiss-Prot ISPH_BUCAP  LytB
[B] Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A)BUCA500133  UniProtKB/Swiss-Prot ISPH_BUCA5  LytB protein
[B] Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)BUCAT00133  UniProtKB/Swiss-Prot ISPH_BUCAT  LytB protein
[B] Enterobacter sakazakii (strain ATCC BAA-894)ENTS803217  UniProtKB/Swiss-Prot ISPH_ENTS8  Putative uncharacterized protein
[B] Erwinia tasmaniensis (strain DSM 17950 / ET1/99)ERWT900715  UniProtKB/Swiss-Prot ISPH_ERWT9  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli (strain 55989 / EAEC)ECO5500026  UniProtKB/Swiss-Prot ISPH_ECO55  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein
[B] Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)ECOLC03524  UniProtKB/Swiss-Prot ISPH_ECOLC  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli (strain DH10B)ECODH00025  UniProtKB/Swiss-Prot ISPH_ECODH  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein
[B] Escherichia coli (strain K12)ECOLI00025  UniProtKB/Swiss-Prot ISPH_ECOLI  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli (strain SE11)ECOSE00027  UniProtKB/Swiss-Prot ISPH_ECOSE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli (strain SMS-3-5 / SECEC)ECOSM00027  UniProtKB/Swiss-Prot ISPH_ECOSM  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O139:H28 (strain E24377A / ETEC)ECO2400027  UniProtKB/Swiss-Prot ISPH_ECO24  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O157:H7ECO5700031  UniProtKB/Swiss-Prot ISPH_ECO57  Residues 1 to 316 of 316 are 100.00 pct identical to residues 1 to 316 of 316 from Escherichia coli K-12 Strain MG1655: B0029 control of stringent response; involved in penicillin tolerance
[B] Escherichia coli O157:H7 (strain EC4115 / EHEC)ECO5E00027  UniProtKB/Swiss-Prot ISPH_ECO5E  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)ECOLU00028  UniProtKB/Swiss-Prot ISPH_ECOLU  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O6ECOL600033  UniProtKB/Swiss-Prot ISPH_ECOL6  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O6:K15:H31 (strain 536)ECOL500027  UniProtKB/Swiss-Prot ISPH_ECOL5  LytB protein
[B] Escherichia coli O7:K1 (strain IAI39 / ExPEC)ECO7I00030  UniProtKB/Swiss-Prot ISPH_ECO7I  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Escherichia coli O9:H4 (strain HS)ECOHS00028  UniProtKB/Swiss-Prot ISPH_ECOHS  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Klebsiella pneumoniae (strain 342)KLEP304613  UniProtKB/Swiss-Prot ISPH_KLEP3  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)KLEP700023  UniProtKB/Swiss-Prot ISPH_KLEP7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Erwinia carotovora (subsp. atroseptica)ERWCT03838  UniProtKB/Swiss-Prot ISPH_ERWCT  Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 isph protein IspH or LytB or b0029 or c0033 or z0034 or ecs0032 SWALL:ISPH_ECOLI (SWALL:P22565) (316 aa) fasta scores: E(): 6.1e-94, 80.69% id in 316 aa IspH protein (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase)
[B] Photorhabdus luminescens (subsp. laumondii)PHOLL00579  UniProtKB/Swiss-Prot ISPH_PHOLL  penicillin tolerance protein
[B] Proteus mirabilis (strain HI4320)PROMH00018  UniProtKB/Swiss-Prot ISPH_PROMH  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Salmonella paratyphi A (strain AKU_12601)SALPK00050  UniProtKB/Swiss-Prot ISPH_SALPK  LytB protein
[B] Salmonella paratyphi-aSALPA00046  UniProtKB/Swiss-Prot ISPH_SALPA  similar to Salmonella typhi CT18 LytB protein LytB protein
[B] Serratia proteamaculans (strain 568)SERP500692  UniProtKB/Swiss-Prot ISPH_SERP5  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)SHIB300027  UniProtKB/Swiss-Prot ISPH_SHIB3  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Shigella boydii serotype 4 (strain Sb227)SHIBS00026  UniProtKB/Swiss-Prot ISPH_SHIBS  control of stringent response; involved in penicillin tolerance; Code: IM; COG: COG0761 LytB
[B] Shigella dysenteriae serotype 1 (strain Sd197)SHIDS00041  UniProtKB/Swiss-Prot ISPH_SHIDS  involved in penicillin tolerance; Code: IM; COG: COG0761 control of stringent response
[B] Shigella flexneriSHIFL00025   NP_705985.1  Residues 1 to 312 of 312 are 99 pct identical to residues 5 to 316 of a 316 aa protein from Escherichia coli O157:H7 EDL933 ref: NP_285723.1 control of stringent response; involved in penicillin tolerance
[B] Shigella flexneri serotype 5b (strain 8401)SHIF800021  UniProtKB/Swiss-Prot ISPH_SHIF8  penicillin tolerance protein Code: IM; COG: COG0761
[B] Shigella sonnei (strain Ss046)SHISS00029  UniProtKB/Swiss-Prot ISPH_SHISS  involved in penicillin tolerance; Code: IM; COG: COG0761 control of stringent response
[B] Wigglesworthia glossinidia brevipalpisWIGBR00292  UniProtKB/Swiss-Prot ISPH_WIGBR  Cellular processes
[B] Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)YERE800580  UniProtKB/Swiss-Prot ISPH_YERE8  LytB protein
[B] Yersinia pestisYERPE00448  UniProtKB/Swiss-Prot ISPH_YERPE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Yersinia pestis (biovar Antiqua strain Antiqua)YERPA03843  UniProtKB/Swiss-Prot ISPH_YERPA  LytB protein
[B] Yersinia pestis (biovar Antiqua strain Nepal516)YERPN00336  UniProtKB/Swiss-Prot ISPH_YERPN  LytB protein
[B] Yersinia pestis (strain Pestoides F)YERPP02978  UniProtKB/Swiss-Prot ISPH_YERPP  LytB protein
[B] Yersinia pestis bv. Antiqua (strain Angola)YERPG00668  UniProtKB/Swiss-Prot ISPH_YERPG  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Yersinia pseudotuberculosisYERPS00616  UniProtKB/Swiss-Prot ISPH_YERPS  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Yersinia pseudotuberculosis (serotype O:1b / strain IP 31758)YERP303388  UniProtKB/Swiss-Prot ISPH_YERP3  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Yersinia pseudotuberculosis serotype IB (strain PB1/+)YERPB00621  UniProtKB/Swiss-Prot ISPH_YERPB  Hydroxymethylbutenyl pyrophosphate reductase
[B] Yersinia pseudotuberculosis serotype O:3 (strain YPIII)YERPY03515  UniProtKB/Swiss-Prot ISPH_YERPY  Hydroxymethylbutenyl pyrophosphate reductase
[B] Blochmannia pennsylvanicus (strain BPEN)BLOPB00115  UniProtKB/Swiss-Prot ISPH_BLOPB  ortholog to Escherichia coli bnum: b0029; MultiFun: Cell processes 5.6.4; Metabolism 1.5.3.19; Regulation 3.1.4 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein
[B] Methylococcus capsulatusMETCA01693  UniProtKB/Swiss-Prot ISPH_METCA  identified by similarity to SP:P22565; match to protein family HMM PF02401; match to protein family HMM TIGR00216 hydroxymethylbutenyl pyrophosphate reductase
[B] Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)ALCBS00460  UniProtKB/Swiss-Prot ISPH_ALCBS  LytB protein
[B] Marinomonas sp. (strain MWYL1)MARMS04155  UniProtKB/TrEMBL A6W343  Hydroxymethylbutenyl pyrophosphate reductase
[B] Actinobacillus pleuropneumoniae serotype 3 (strain JL03)ACTPJ01483  UniProtKB/Swiss-Prot ISPH_ACTPJ  Hydroxymethylbutenyl pyrophosphate reductase
[B] Actinobacillus pleuropneumoniae serotype 5b (strain L20)ACTP201486  UniProtKB/Swiss-Prot ISPH_ACTP2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Actinobacillus pleuropneumoniae serotype 7 (strain AP76)ACTP701550  UniProtKB/Swiss-Prot ISPH_ACTP7  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Actinobacillus succinogenes (strain ATCC 55618 / 130Z)ACTSZ01841  UniProtKB/Swiss-Prot ISPH_ACTSZ  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus ducreyiHAEDU00052  UniProtKB/Swiss-Prot ISPH_HAEDU  hydroxymethylbutenyl pyrophosphate reductase
[B] Haemophilus influenzaeHAEIN00993  UniProtKB/Swiss-Prot ISPH_HAEIN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus influenzae (strain 86-028NP)HAEI801037  UniProtKB/Swiss-Prot ISPH_HAEI8  Similar to: HI1007, ISPH_HAEIN 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus influenzae (strain PittEE)HAEIE01212  UniProtKB/Swiss-Prot ISPH_HAEIE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus influenzae (strain PittGG)HAEIG01414  UniProtKB/Swiss-Prot ISPH_HAEIG  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus parasuis serovar 5 (strain SH0165)HAEPS01175  UniProtKB/Swiss-Prot ISPH_HAEPS  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus somnus (strain 129PT)HAES100187  UniProtKB/TrEMBL Q0I1W0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Haemophilus somnus (strain 2336)HAES200050  UniProtKB/Swiss-Prot ISPH_HAES2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mannheimia succiniciproducens (strain MBEL55E)MANSM01743  UniProtKB/Swiss-Prot ISPH_MANSM  Penicillin tolerance protein LytB protein
[B] Pasteurella multocidaPASMU01664  UniProtKB/Swiss-Prot ISPH_PASMU  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acinetobacter baumannii (strain AB0057)ACIB503439  UniProtKB/Swiss-Prot ISPH_ACIB5  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acinetobacter baumannii (strain AB307-0294)ACIB300330  UniProtKB/Swiss-Prot ISPH_ACIB3  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acinetobacter baumannii (strain ACICU)ACIBC03359  UniProtKB/Swiss-Prot ISPH_ACIBC  Penicillin tolerance protein
[B] Acinetobacter baumannii (strain AYE)ACIBY00297  UniProtKB/Swiss-Prot ISPH_ACIBY  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Acinetobacter baumannii (strain SDF)ACIBS00265  UniProtKB/Swiss-Prot ISPH_ACIBS  Putative uncharacterized protein
[B] Acinetobacter sp. (strain ADP1)ACIAD02991  UniProtKB/Swiss-Prot ISPH_ACIAD  Evidence 1 : Function experimentally demonstrated in the studied organism; PubMedId : 10763755; Product type e : enzyme 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with relA to maintain it in an inactive form during normal growth.)
[B] Psychrobacter cryohalolentis (strain K5)PSYCK01983  UniProtKB/Swiss-Prot ISPH_PSYCK  hydroxymethylbutenyl pyrophosphate reductase
[B] Psychrobacter sp. (strain PRwf-1)PSYWF00569  UniProtKB/Swiss-Prot ISPH_PSYWF  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Cellvibrio japonicus (strain Ueda107)CELJU03107  UniProtKB/TrEMBL B3PE11  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas aeruginosaPSEAE04546  UniProtKB/Swiss-Prot ISPH_PSEAE  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas aeruginosa (strain LESB58)PSEA804913  UniProtKB/Swiss-Prot ISPH_PSEA8  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas aeruginosa (strain PA7)PSEA705096  UniProtKB/TrEMBL A6VBU4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas aeruginosa (strain UCBPP-PA14)PSEAB04855  UniProtKB/Swiss-Prot ISPH_PSEAB  penicillin tolerance protein, LytB
[B] Pseudomonas entomophila (strain L48)PSEE404353  UniProtKB/Swiss-Prot ISPH_PSEE4  hydroxymethylbutenyl pyrophosphate reductase Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme
[B] Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)PSEF505233  UniProtKB/Swiss-Prot ISPH_PSEF5  identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216 hydroxymethylbutenyl pyrophosphate reductase
[B] Pseudomonas fluorescens (strain PfO-1)PSEPF04835  UniProtKB/Swiss-Prot ISPH_PSEPF  LytB protein
[B] Pseudomonas mendocina (strain ymp)PSEMY00940  UniProtKB/Swiss-Prot ISPH_PSEMY  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas putida (strain F1 / ATCC 700007)PSEP100637  UniProtKB/Swiss-Prot ISPH_PSEP1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas putida (strain GB-1)PSEPG00644  UniProtKB/Swiss-Prot ISPH_PSEPG  hydroxymethylbutenyl pyrophosphate reductase unknown EC_number=1.17.1.2 KEGG: pen:PSEEN4689 hydroxymethylbutenyl pyrophosphate reductase TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Pseudomonas putida (strain KT2440)PSEPK00596  UniProtKB/Swiss-Prot ISPH_PSEPK  identified by match to TIGR protein family HMM TIGR00216 hydroxymethylbutenyl pyrophosphate reductase
[B] Pseudomonas putida (strain W619)PSEPW04528  UniProtKB/Swiss-Prot ISPH_PSEPW  Hydroxymethylbutenyl pyrophosphate reductase
[B] Pseudomonas syringae (pv. tomato)PSESM00770  UniProtKB/Swiss-Prot ISPH_PSESM  hydroxymethylbutenyl pyrophosphate reductase
[B] Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)PSE1400685  UniProtKB/Swiss-Prot ISPH_PSE14  identified by match to protein family HMM PF02401; match to protein family HMM TIGR00216 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Pseudomonas syringae pv. syringae (strain B728a)PSEU200705  UniProtKB/Swiss-Prot ISPH_PSEU2  LytB protein
[B] Francisella philomiragia subsp. philomiragia (strain ATCC 25017)FRAP200455  UniProtKB/Swiss-Prot ISPH_FRAP2  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Francisella tularensis (subsp. tularensis)FRATT00801  UniProtKB/Swiss-Prot ISPH_FRATT  Similar to ISPH_ECOLI (P22565) IspH protein from Escherichia coli (316 aa). FASTA: opt: 1142 Z-score: 1401.3 E(): 3.7e-70 Smith-Waterman score: 1142; 52.885 identity (52.885 ungapped) in 312 aa overlap. IspH protein
[B] Francisella tularensis subsp. holarctica (strain FTA)FRATF00256  UniProtKB/Swiss-Prot ISPH_FRATF  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Francisella tularensis subsp. holarctica (strain LVS)FRATH00290  UniProtKB/Swiss-Prot ISPH_FRATH  IspH protein
[B] Francisella tularensis subsp. holarctica (strain OSU18)FRATO00243  UniProtKB/Swiss-Prot ISPH_FRATO  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Francisella tularensis subsp. mediasiatica (strain FSC147)FRATM00334  UniProtKB/Swiss-Prot ISPH_FRATM  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
[B] Francisella tularensis subsp. novicida (strain U112)FRATN00343  UniProtKB/Swiss-Prot ISPH_FRATN  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
[B] Francisella tularensis subsp. tularensis (strain WY96-3418)FRATW01054  UniProtKB/Swiss-Prot ISPH_FRATW  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Mycobacteriophage FRAT1FRAT100799  UniProtKB/Swiss-Prot ISPH_FRAT1  IspH protein Similar to ISPH_ECOLI (P22565) IspH protein from Escherichia coli (316 aa). FASTA: opt: 1142 Z-score: 1401.3 E(): 3.7e-70 Smith-Waterman score: 1142; 52.885 identity (52.885 ungapped) in 312 aa overlap.
[B] Photobacterium profundumPHOPR00546  UniProtKB/Swiss-Prot ISPH_PHOPR  putative LytB protein
[B] Vibrio choleraeVIBCH00673  UniProtKB/TrEMBL A1F6Q7  similar to GB:D10483 SP:P22565 GB:X54945 PID:216456 PID:41933; identified by sequence similarity; putative lytB protein
[B] Vibrio cholerae (strain ATCC 39541 / O395)VIBC300206  UniProtKB/TrEMBL A5F8X5  Hydroxymethylbutenyl pyrophosphate reductase
[B] Vibrio cholerae serotype O1 (strain M66-2)VIBCM00628  UniProtKB/TrEMBL C3LSU0  
[B] Vibrio harveyi (strain ATCC BAA-1116 / BB120)VIBHB00852  UniProtKB/TrEMBL A7MTD9  Putative uncharacterized protein
[B] Vibrio parahaemolyticusVIBPA00537  UniProtKB/TrEMBL A6B564  similar to GB:AAF93850.1 (AE004154) percent identity 88 in 321 aa LytB protein
[B] Vibrio splendidus (strain LGP32)VIBSL00483  UniProtKB/TrEMBL B7VJM0  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Vibrio vulnificusVIBVU00472   NP_759496.1  COG0761 Penicillin tolerance protein
[B] Vibrio vulnificus (strain YJ016)VIBVY00688  UniProtKB/Swiss-Prot ISPH_VIBVY  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Stenotrophomonas maltophilia (strain K279a)STRMK01255  UniProtKB/Swiss-Prot ISPH_STRMK  Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Stenotrophomonas maltophilia (strain R551-3)STRM501123  UniProtKB/Swiss-Prot ISPH_STRM5  Hydroxymethylbutenyl pyrophosphate reductase
[B] Xanthomonas axonopodis (pv. citri)XANAC01220  UniProtKB/Swiss-Prot ISPH_XANAC  identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark penicillin tolerance protein
[B] Xanthomonas campestris pv. campestrisXANCP01127  UniProtKB/Swiss-Prot ISPH_XANCP  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Xanthomonas campestris pv. campestris (strain 8004)XANC802989  UniProtKB/Swiss-Prot ISPH_XANC8  penicillin tolerance protein
[B] Xanthomonas campestris pv. campestris (strain B100)XANCB03163  UniProtKB/Swiss-Prot ISPH_XANCB  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Xanthomonas campestris pv. vesicatoria (strain 85-10)XANC501265  UniProtKB/Swiss-Prot ISPH_XANC5  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Xanthomonas oryzae (pv. oryzae)XANOR01462  UniProtKB/TrEMBL Q5H2D9  identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark penicillin tolerance protein
[B] Xanthomonas oryzae pv. oryzae (strain MAFF 311018)XANOM01382  UniProtKB/Swiss-Prot ISPH_XANOM  penicillin tolerance protein identified by sequence similarity; putative; ORF located using Blastx/Glimmer/GeneHacker
[B] Xanthomonas oryzae pv. oryzae (strain PXO99A)XANOP01419  UniProtKB/Swiss-Prot ISPH_XANOP  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Xylella fastidiosaXYLFA02368  UniProtKB/Swiss-Prot ISPH_XYLFA  similar to GI|5915671 (percent identity: 64 %/query alignment coverage: 99.4 %/subject alignment coverage: 99.4 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder drug tolerance protein
[B] Xylella fastidiosa (strain M12)XYLFM01383  UniProtKB/Swiss-Prot ISPH_XYLFM  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Xylella fastidiosa (strain M23)XYLF201427  UniProtKB/Swiss-Prot ISPH_XYLF2  Hydroxymethylbutenyl pyrophosphate reductase
[B] Xylella fastidiosa (strain Temecula1 / ATCC 700964)XYLFT01340  UniProtKB/Swiss-Prot ISPH_XYLFT  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Ruthia magnifica subsp. Calyptogena magnificaRUTMC00924  UniProtKB/Swiss-Prot ISPH_RUTMC  Hydroxymethylbutenyl pyrophosphate reductase
[B] Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)VESOH00885  UniProtKB/Swiss-Prot ISPH_VESOH  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Magnetococcus sp. (strain MC-1)MAGSM03259  UniProtKB/Swiss-Prot ISPH_MAGSM  hydroxymethylbutenyl pyrophosphate reductase KEGG: ngo:NGO0072 putative penicillin tolerance protein TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase PFAM: LytB protein
[B] Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)LEPBP01548  UniProtKB/TrEMBL B0SQZ4  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)LEPBA01499  UniProtKB/TrEMBL B0SHI6  Penicillin tolerance protein
[B] Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)LEPBJ01553  UniProtKB/TrEMBL Q04RX6  Penicillin tolerance protein cytoplasmic protein
[B] Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)LEPBL01251  UniProtKB/TrEMBL Q051P5  Penicillin tolerance protein cytoplasmic protein
[B] Leptospira interrogansLEPIN02402  UniProtKB/Swiss-Prot ISPH_LEPIN  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Leptospira interrogans (serogroup Icterohaemorrhagiae / serovar Copenhageni)LEPIC01477  UniProtKB/Swiss-Prot ISPH_LEPIC  identified by sequence similarity; putative; ORF located using Blastx/Glimmer penicillin tolerance protein
[B] Petrotoga mobilis (strain DSM 10674 / SJ95)PETMO01555  UniProtKB/Swiss-Prot ISPH_PETMO  Hydroxymethylbutenyl pyrophosphate reductase
[B] Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)THELT01631  UniProtKB/Swiss-Prot ISPH_THELT  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
[B] Opitutus terrae (strain DSM 11246 / PB90-1)OPITP03621  UniProtKB/Swiss-Prot ISPH_OPITP  Hydroxymethylbutenyl pyrophosphate reductase