Entry MOUSE03581 (INP5K_MOUSE)

EMus musculus

Information

Description
inositol polyphosphate 5-phosphatase K [Source:MGI Symbol;Acc:MGI:1194899]
Organism
MOUSE - Mus musculus
Locus
Chromosome 11: join(75631100..75631197, 75633069..75633176, 75633463..75633571, 75636944..75637060, (more...)
Protein Structures
pmp logo Protein Model Portal: Q5ND43

IDs and Cross-references

UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot INP5K_MOUSE (Acc.: Q8C5L6)
UniProtKB/TrEMBL
UniProtKB/TrEMBL Q5ND43
Ensembl
Ensembl ENSMUSG00000006127.9, Ensembl ENSMUSP00000006286.2, Ensembl ENSMUST00000006286.8
Refseq
Refseq logo NP_032942(Acc.:Refseq logo NP_032942.1Refseq logo GI: 6679449)
EntrezGene
Entrez logo 19062
Other IDs
AAC53265, AAC60757, AAH66112, AAL90796, AAL90797, BAC35778, BAC37126, BAE37720, EDL12831

Domain Architecture

Gene Ontology

Molecular function
GO termEvidence and reference
inositol-polyphosphate 5-phosphatase activity (GO:0004445) IEA: GO_REF:003
vasopressin receptor activity (GO:0005000) IDA: PMID:21938401
inositol bisphosphate phosphatase activity (GO:0016312) IMP: PMID:19250614
ISS: GO_REF:024
ISO: PMID:18573875, GO_REF:096
IEA: GO_REF:019
hydrolase activity (GO:0016787) IEA: GO_REF:037, GO_REF:038
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485) IDA: PMID:21938401
ISO: GO_REF:096
IEA: GO_REF:019
phosphatidylinositol trisphosphate phosphatase activity (GO:0034594) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
phosphatidylinositol phosphate 5-phosphatase activity (GO:0034595) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
inositol trisphosphate phosphatase activity (GO:0046030) ISS: GO_REF:024
ISO: PMID:18573875, GO_REF:096
IEA: GO_REF:019
inositol-1,4,5-trisphosphate 5-phosphatase activity (GO:0052658) IEA: GO_REF:003
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (GO:0052659) IEA: GO_REF:003

Cellular component
GO termEvidence and reference
ruffle (GO:0001726) ISS: GO_REF:024
ISA: PMID:12536145
IEA: GO_REF:019
nucleus (GO:0005634) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
cytoplasm (GO:0005737) IDA: PMID:21938401
endoplasmic reticulum (GO:0005783) ISS: GO_REF:024
ISO: GO_REF:096
ISA: PMID:12536145
IEA: GO_REF:019, GO_REF:037, GO_REF:039
trans-Golgi network (GO:0005802) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
cytosol (GO:0005829) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
plasma membrane (GO:0005886) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
membrane (GO:0016020) ISS: GO_REF:024
ISO: GO_REF:096
ISA: PMID:12536145
IEA: GO_REF:019
ruffle membrane (GO:0032587) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
neuron projection (GO:0043005) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
perinuclear region of cytoplasm (GO:0048471) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019

Biological process
GO termEvidence and reference
in utero embryonic development (GO:0001701) IMP: PMID:18573875
negative regulation of protein phosphorylation (GO:0001933) IDA: PMID:21938401
regulation of glycogen biosynthetic process (GO:0005979) IMP: PMID:19250614
negative regulation of protein kinase activity (GO:0006469) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
G-protein coupled receptor signaling pathway (GO:0007186) IDA: PMID:21938401
negative regulation of peptidyl-threonine phosphorylation (GO:0010801) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of glucose transport (GO:0010829) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
dephosphorylation (GO:0016311) IDA: PMID:21938401
ISO: GO_REF:096
IEA: GO_REF:019
response to insulin (GO:0032868) IMP: PMID:18573875
cellular response to insulin stimulus (GO:0032869) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
cellular response to hormone stimulus (GO:0032870) IDA: PMID:21938401
negative regulation of peptidyl-serine phosphorylation (GO:0033137) IMP: PMID:18573875, PMID:19250614
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of dephosphorylation (GO:0035305) IMP: PMID:19250614
positive regulation of urine volume (GO:0035810) IDA: PMID:21938401
glucose homeostasis (GO:0042593) IMP: PMID:18573875, PMID:19250614
negative regulation of MAP kinase activity (GO:0043407) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation by host of viral transcription (GO:0043922) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of glycogen biosynthetic process (GO:0045719) IMP: PMID:19250614
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045869) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of transcription, DNA-templated (GO:0045892) IDA: PMID:21938401
positive regulation of transcription, DNA-templated (GO:0045893) IDA: PMID:21938401
negative regulation of insulin receptor signaling pathway (GO:0046627) IMP: PMID:19250614
ISO: GO_REF:096
IEA: GO_REF:019
inositol phosphate dephosphorylation (GO:0046855) ISA: PMID:12536145
IEA: GO_REF:019
phosphatidylinositol dephosphorylation (GO:0046856) ISS: GO_REF:024
ISO: GO_REF:096
ISA: PMID:12536145
IEA: GO_REF:002, GO_REF:019
negative regulation of stress fiber assembly (GO:0051497) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of protein kinase B signaling (GO:0051898) IMP: PMID:19250614
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of calcium ion transport (GO:0051926) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
cellular response to cAMP (GO:0071320) IDA: PMID:21938401
cellular response to tumor necrosis factor (GO:0071356) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
cellular response to epidermal growth factor stimulus (GO:0071364) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
protein targeting to plasma membrane (GO:0072661) IDA: PMID:21938401
negative regulation of protein targeting to membrane (GO:0090315) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
ruffle assembly (GO:0097178) ISS: GO_REF:024
ISO: GO_REF:096
IEA: GO_REF:019
negative regulation of glycogen (starch) synthase activity (GO:2000466) IMP: PMID:19250614
positive regulation of renal water transport (GO:2001153) IDA: PMID:21938401

Protein Sequence

MQHGDRNTPG YREGIMSAVS LRRPSAPKGF ALSVHVVTWN VASAAPTVDL SDLLQLNNQD    60
LNLDIYIIGL QEMNFGIISL LSDAAFEDPW SSLFMDMLSP LNFVKISQVR MQGLLLLVFA   120
KYQHLPYIQI ISTKSTPTGL YGYWGNKGGV NVCLKLYGYY VSIINCHLPP HMYNNDQRLE   180
HFDRILESLT FEGYDVPNIL DHDLILWFGD MNFRIEDFGL LFVQESITRK YYKELWEKDQ   240
LFIAKKNDQL LREFQEGPLL FPPTYKFDRH SNNYDTSEKK RKPAWTDRIL WRLKRQPSQA   300
SPLASSVPTS YFLLTLKNYV SHMAYSISDH KPVTGTFDLE LNPLMSVPLI TMMPEHLWTM   360
ENDMLISYTS TPEFLSSSWD WIGLYKVGMR HINDYVAYVW VGDNQVSYGN NPNQVYINIS   420
AIPDTEDQFL LCYYSNNLHS VVGISQPFKI PIRSFLREDT LYEPEPQI                468